期刊
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fbioe.2021.719047
关键词
reparative inflammation; wound healing; tendon; tendinopathy; regeneration
资金
- NIH/NIAMS [R01 AR069537, R56 AR076984, F31 AR076905]
Inflammation plays a dual role in tendon healing, serving as the root cause of chronic tendinopathy while also aiding tissue repair. Recent research focuses on the cells and cytokines involved in reparative inflammation.
Tendon injuries are common and debilitating, with non-regenerative healing often resulting in chronic disease. While there has been considerable progress in identifying the cellular and molecular regulators of tendon healing, the role of inflammation in tendon healing is less well understood. While inflammation underlies chronic tendinopathy, it also aids debris clearance and signals tissue repair. Here, we highlight recent findings in this area, focusing on the cells and cytokines involved in reparative inflammation. We also discuss findings from other model systems when research in tendon is minimal, and explore recent studies in the treatment of human tendinopathy to glean further insights into the immunobiology of tendon healing.
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