4.7 Review

Liver Fibrosis: Therapeutic Targets and Advances in Drug Therapy

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Gastroenterology & Hepatology

Obeticholic Acid Impact on Quality of Life in Patients With Nonalcoholic Steatohepatitis: REGENERATE 18-Month Interim Analysis

Zobair M. Younossi et al.

Summary: This study assessed the health-related quality of life (HRQoL) in patients with nonalcoholic steatohepatitis (NASH) and found that treatment with obeticholic acid (OCA) significantly improved fibrosis in these patients. The study also showed that OCA therapy initially caused mild pruritus, but did not worsen over time.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2022)

Article Medicine, General & Internal

Accuracy of gamma-glutamyl transpeptidase-to-platelet ratio (GPR), red cell distribution width (RDW), aspartate aminotransferase-to-platelet ratio index (APRI), and the fibrosis-4 index (FIB4) compared with liver biopsy in patients with drug-induced liver injury (DILI)

Minjie Wan et al.

Summary: This study aimed to evaluate the accuracy of four different indices in predicting the severity of inflammation in drug-induced liver injury patients, and found that APRI and FIB4 indices have higher predictive ability for patients with inflammation higher than G2.

MEDICINE (2021)

Review Oncology

Non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH)-related liver fibrosis: mechanisms, treatment and prevention

Frank Tacke et al.

Summary: Liver fibrosis is characterized by excessive extracellular matrix protein expression and accumulation in the liver, often resulting from chronic injury and inflammation. Currently, there are limited therapeutic options available for fibrosis, with liver transplantation being the last resort in advanced stages. Preventive strategies, including lifestyle modifications, are crucial to avoid complications such as cirrhosis and liver cancer. Promising developments in antifibrotic drug candidates offer hope for effective pharmacological therapy in the future.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

Article Gastroenterology & Hepatology

NGM282 Improves Liver Fibrosis and Histology in 12 Weeks in Patients With Nonalcoholic Steatohepatitis

Stephen A. Harrison et al.

HEPATOLOGY (2020)

Article Chemistry, Multidisciplinary

WZ66, a novel acetyl-CoA carboxylase inhibitor, alleviates nonalcoholic steatohepatitis (NASH) in mice

Ying-sheng Gao et al.

ACTA PHARMACOLOGICA SINICA (2020)

Article Medicine, Research & Experimental

Cenicriviroc for the treatment of liver fibrosis in adults with nonalcoholic steatohepatitis: AURORA Phase 3 study design

Quentin M. Anstee et al.

CONTEMPORARY CLINICAL TRIALS (2020)

Article Pharmacology & Pharmacy

Pegbelfermin (BMS-986036): an investigational PEGylated fibroblast growth factor 21 analogue for the treatment of nonalcoholic steatohepatitis

Cristy R. C. Verzijl et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2020)

Article Biochemistry & Molecular Biology

Selonsertib Inhibits Liver Fibrosis via Downregulation of ASK1/MAPK Pathway of Hepatic Stellate Cells

Young-Chan Yoon et al.

BIOMOLECULES & THERAPEUTICS (2020)

Review Cell Biology

Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives

Natascha Roehlen et al.

Article Gastroenterology & Hepatology

Acetyl-CoA Carboxylase Inhibition Improves Multiple Dimensions of NASH Pathogenesis in Model Systems

Trenton T. Ross et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2020)

Article Gastroenterology & Hepatology

Emricasan Improves Liver Function in Patients With Cirrhosis and High Model for End-Stage Liver Disease Scores Compared With Placebo

Catherine T. Frenette et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2019)

Article Gastroenterology & Hepatology

Burden of liver diseases in the world

Sumeet K. Asrani et al.

JOURNAL OF HEPATOLOGY (2019)

Article Biochemistry & Molecular Biology

Interleukin-1 Receptor Antagonist Modulates Liver Inflammation and Fibrosis in Mice in a Model-Dependent Manner

Raphael P. H. Meier et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Gastroenterology & Hepatology

MicroRNA-101 suppresses liver fibrosis by downregulating PI3K/Akt/mTOR signaling pathway

Yang Lei et al.

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY (2019)

Article Biochemistry & Molecular Biology

Alogliptin alleviates liver fibrosis via suppression of activated hepatic stellate cell

Hanyan Zhang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Article Medicine, Research & Experimental

Fluorofenidone affects hepatic stellate cell activation in hepatic fibrosis by targeting the TGF-β1/Smad and MAPK signaling pathways

Yu Peng et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2019)

Article Medicine, Research & Experimental

RAP-8 ameliorates liver fibrosis by modulating cell cycle and oxidative stress

Hongjiao Xu et al.

LIFE SCIENCES (2019)

Article Biochemistry & Molecular Biology

Rosiglitazone ameliorates bile duct ligation-induced liver fibrosis by down-regulating NF-κB-TNF-α signaling pathway in a PPARγ-dependent manner

Zhuo Wei et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Article Gastroenterology & Hepatology

A randomized, placebo-controlled trial of emricasan in patients with NASH and F1-F3 fibrosis

Stephen A. Harrison et al.

JOURNAL OF HEPATOLOGY (2019)

Article Medicine, Research & Experimental

Pirfenidone alleviates concanavalin A-induced liver fibrosis in mice

Mostafa M. Salah et al.

LIFE SCIENCES (2019)

Article Gastroenterology & Hepatology

Emricasan Ameliorates Portal Hypertension and Liver Fibrosis in Cirrhotic Rats Through a Hepatocyte-Mediated Paracrine Mechanism

Jordi Gracia-Sancho et al.

HEPATOLOGY COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

Synergistic effects of simvastatin and bone marrow-derived mesenchymal stem cells on hepatic fibrosis

Yoon Ok Jang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Article Biochemistry & Molecular Biology

Inhibition of canonical WNT signaling pathway by β-catenin/CBP inhibitor ICG-001 ameliorates liver fibrosis in vivo through suppression of stromal CXCL12

Busra Ozturk Akcora et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)

Review Biochemistry & Molecular Biology

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) and liver fibrosis: A review

Keywan Mortezaee

CELL BIOCHEMISTRY AND FUNCTION (2018)

Editorial Material Pharmacology & Pharmacy

Cenicriviroc for the treatment of non-alcoholic steatohepatitis and liver fibrosis

Frank Tacke

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2018)

Article Pharmacology & Pharmacy

Effects of pirfenidone in acute and sub-chronic liver fibrosis, and an initiation-promotion cancer model in the mouse

Oleksii Seniutkin et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2018)

Review Gastroenterology & Hepatology

Liver fibrosis

M. Merve Aydin et al.

TURKISH JOURNAL OF GASTROENTEROLOGY (2018)

Article Gastroenterology & Hepatology

GS-0976 Reduces Hepatic Steatosis and Fibrosis Markers in Patients With Nonalcoholic Fatty Liver Disease

Rohit Loomba et al.

GASTROENTEROLOGY (2018)

Review Biochemistry & Molecular Biology

Wnt/β-Catenin Signaling as a Potential Target for the Treatment of Liver Cirrhosis Using Antifibrotic Drugs

Koji Nishikawa et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Biochemistry & Molecular Biology

Danger-Associated Molecular Patterns (DAMPs): Molecular Triggers for Sterile Inflammation in the Liver

Sabine Mihm

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Medicine, General & Internal

Noncanonical farnesoid X receptor signaling inhibits apoptosis and impedes liver fibrosis

Hong Wang et al.

EBIOMEDICINE (2018)

Reprint Medicine, General & Internal

Sofosbuvir/Velpatasvir (Epclusa) for Hepatitis C (Reprinted from The Medical Letter on Drugs and Therapeutics, vol 58, 107-109, 2016)

Mark Abramowicz et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2017)

Article Gastroenterology & Hepatology

The FXR agonist PX20606 ameliorates portal hypertension by targeting vascular remodelling and sinusoidal dysfunction

Philipp Schwabl et al.

JOURNAL OF HEPATOLOGY (2017)

Review Gastroenterology & Hepatology

Regression of Liver Fibrosis

Lara Campana et al.

SEMINARS IN LIVER DISEASE (2017)

Article Gastroenterology & Hepatology

Reversal of liver fibrosis: From fiction to reality

Miguel Eugenio Zoubek et al.

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY (2017)

Review Biochemistry & Molecular Biology

The PDGF system and its antagonists in liver fibrosis

Erawan Borkham-Kamphorst et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2016)

Article Gastroenterology & Hepatology

Early changes in dynamic biomarkers of liver fibrosis in hepatitis C virus-infected patients treated with sofosbuvir

Sebastian Bernuth et al.

DIGESTIVE AND LIVER DISEASE (2016)

Article Pharmacology & Pharmacy

Fibroblast growth factor 21 attenuates hepatic fibrogenesis through TGF-β/smad2/3 and NF-κB signaling pathways

Pengfei Xu et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2016)

Article Pharmacology & Pharmacy

Role of histone deacetylases(HDACs) in progression and reversal of liver fibrosis

Xing Li et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2016)

Article Pharmacology & Pharmacy

Tracking anti-fibrotic pathways of nilotinib and imatinib in experimentally induced liver fibrosis: An insight

Gamal E. Shiha et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2014)

Article Biochemistry & Molecular Biology

Dual inhibition of Src family kinases and Aurora kinases by SU6656 modulates CTGF (connective tissue growth factor) expression in an ERK-dependent manner

Iwona Cicha et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2014)

Review Endocrinology & Metabolism

De nova lipogenesis in health and disease

Fatima Ameer et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2014)

Article Gastroenterology & Hepatology

Hepatic stellate cells and portal fibroblasts are the major cellular sources of collagens and lysyl oxidases in normal liver and early after injury

Maryna Perepelyuk et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2013)

Article Biochemistry & Molecular Biology

Extracellular matrix degradation in liver fibrosis: Biochemistry and regulation

John P. Iredale et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2013)

Editorial Material Gastroenterology & Hepatology

Dissecting the role of CB1 receptors on chronic liver diseases

Ramon Bataller et al.

Article Multidisciplinary Sciences

Preventive Effect of Halofuginone on Concanavalin A-Induced Liver Fibrosis

Jie Liang et al.

PLOS ONE (2013)

Article Biochemistry & Molecular Biology

Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo

Joy X. Jiang et al.

FREE RADICAL BIOLOGY AND MEDICINE (2012)

Article Medicine, Research & Experimental

Reversal of liver fibrosis by the antagonism of endocannabinoid CB1 receptor in a rat model of CCl4-induced advanced cirrhosis

Ferdinando A. Giannone et al.

LABORATORY INVESTIGATION (2012)

Article Gastroenterology & Hepatology

Update on hepatic stellate cells: pathogenic role in liver fibrosis and novel isolation techniques

Frank Tacke et al.

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY (2012)

Article Medicine, General & Internal

Elevated TGF-beta 1 levels might protect HCV/HIV-coinfected patients from liver fibrosis

Norma I. Rallon et al.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2011)

Article Gastroenterology & Hepatology

Histological regression of liver fibrosis with immunosuppressive therapy in autoimmune hepatitis

Jose Miguel Valera et al.

GASTROENTEROLOGIA Y HEPATOLOGIA (2011)

Article Gastroenterology & Hepatology

Sitagliptin as a Novel Treatment Agent for Non-Alcoholic Fatty Liver Disease Patients with Type 2 Diabetes Mellitus

Tomoyuki Iwasaki et al.

HEPATO-GASTROENTEROLOGY (2011)

Article Cell Biology

Src Is a Major Signaling Component for CTGF Induction by TGF-β1 in Osteoblasts

X. Zhang et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2010)

Article Medicine, Research & Experimental

Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice

Marie-Luise Berres et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

Article Gastroenterology & Hepatology

New insights into the antifibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis

Yan Wang et al.

JOURNAL OF HEPATOLOGY (2010)

Article Gastroenterology & Hepatology

Increased liver stiffness in alcoholic liver disease: Differentiating fibrosis from steatohepatitis

Sebastian Mueller et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2010)

Review Gastroenterology & Hepatology

Update on the pathophysiology of liver fibrosis

Massimo Pinzani et al.

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY (2010)

Article Gastroenterology & Hepatology

Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C

Jordi Colmenero et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2009)

Article Gastroenterology & Hepatology

Pan-Caspase Inhibitor VX-166 Reduces Fibrosis in an Animal Model of Nonalcoholic Steatohepatitis

Rafal P. Witek et al.

HEPATOLOGY (2009)

Article Gastroenterology & Hepatology

Pentoxifylline prevents pig serum-induced rat liver fibrosis by inhibiting interleukin-6 production

Kyoko Toda et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2009)

Article Medicine, Research & Experimental

TGF-β1 Gene Silencing for Treating Liver Fibrosis

Kun Cheng et al.

MOLECULAR PHARMACEUTICS (2009)

Review Gastroenterology & Hepatology

Non-alcoholic fatty liver disease: The mist gradually clears

Nimantha Mark Wilfred de Alwis et al.

JOURNAL OF HEPATOLOGY (2008)

Article Biotechnology & Applied Microbiology

Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone

Yasushi Sato et al.

NATURE BIOTECHNOLOGY (2008)

Article Biochemistry & Molecular Biology

NOX in liver fibrosis

Sarnuele De Minicis et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2007)

Article Biochemistry & Molecular Biology

CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis

Fatima Teixeira-Clerc et al.

NATURE MEDICINE (2006)

Article Gastroenterology & Hepatology

Mechanisms of liver injury.: I.: TNF-α-induced liver injury:: role of IKK, JNK, and ROS pathways

RF Schwabe et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2006)

Article Critical Care Medicine

RNAi

TG Buchman

CRITICAL CARE MEDICINE (2005)

Review Multidisciplinary Sciences

Smad-dependent and Smad-independent pathways in TGF-β family signalling

R Derynck et al.

NATURE (2003)

Article Gastroenterology & Hepatology

Halofuginone to prevent and treat thioacetamide-induced liver fibrosis in rats

R Bruck et al.

HEPATOLOGY (2001)