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Immunopathology and Immunosenescence, the Immunological Key Words of Severe COVID-19. Is There a Role for Stem Cell Transplantation?

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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In Response to Author: COVID-19 and T Cells: Do T Cells Really Matter?

Sonali Vadi et al.

INDIAN JOURNAL OF CRITICAL CARE MEDICINE (2023)

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Article Nutrition & Dietetics

Vitamin D deficiency in critically ill COVID-19 ARDS patients

Quirin Notz et al.

Summary: Vitamin D deficiency is common in COVID-19 ARDS patients. While 25-hydroxyvitamin D status is not related to clinical course changes, low levels of 1,25-dihydroxyvitamin D are associated with prolonged mechanical ventilation and a worse APACHE II score.

CLINICAL NUTRITION (2022)

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Article Cell Biology

T cell counts and IL-6 concentration in blood of North African COVID-19 patients are two independent prognostic factors for severe disease and death

Brahim Belaid et al.

Summary: The study revealed significant differences in lymphocyte subsets and cytokine levels among COVID-19 patients with different disease severity and survival status. Higher levels of IL-6 and IL-10 were associated with severe illness and death, while Th17 percentages in peripheral blood were higher than healthy controls. IL-6 levels >106.44 pg/ml and CD8+ T cell counts <150 cells/mu l were found to be predictors of mortality.

JOURNAL OF LEUKOCYTE BIOLOGY (2022)

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Review Immunology

A systematic review of asymptomatic infections with COVID-19

Zhiru Gao et al.

Summary: Since the outbreak of COVID-19 at the end of December 2019, it has caused significant harm and challenges to over 200 countries and regions worldwide. Many patients with COVID-19 are asymptomatic or have only mild symptoms, yet they can still spread the virus, making screening for asymptomatic infections difficult and complicating national prevention and control efforts.

JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION (2021)

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Review Biochemistry & Molecular Biology

Type I IFN-dependent antibody response at the basis of sex dimorphism in the outcome of COVID-19

Lucia Gabriele et al.

Summary: In the COVID-19 pandemic, males are more prone to severe pneumonia and death, while females have a higher capacity to produce antibodies, which could lead to better survival rates.

CYTOKINE & GROWTH FACTOR REVIEWS (2021)

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Article Virology

Apoptosis and immunophenotyping of peripheral blood lymphocytes in Iranian COVID-19 patients: Clinical and laboratory characteristics

Saeid Taghiloo et al.

Summary: A novel human coronavirus, SARS-CoV-2, has been identified in China and spread globally, with studies showing a decrease in peripheral blood lymphocytes in most patients. This study in Iranian COVID-19 patients revealed decreased lymphocyte subsets compared to controls, particularly in severe cases. The increase in apoptosis of mononuclear cells in COVID-19 patients, especially in severe cases, suggests potential biomarkers for severity and prognosis.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Letter Virology

Peripheral biomarkers' panel for severe COVID-19 patients

Miriana d'Alessandro et al.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Article Endocrinology & Metabolism

Independent Role of Severe Obesity as a Risk Factor for COVID-19 Hospitalization: A Spanish Population-Based Cohort Study

Ujue Fresan et al.

Summary: Severe obesity is a significant risk factor for COVID-19 hospitalization and severity in young adults, especially pronounced in those under 50 years old, with minimal impact on individuals aged 65 to 79 years. Sex and chronic conditions do not modify the effect of class 3 obesity in any outcomes.

OBESITY (2021)

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Review Cell Biology

Aging in COVID-19: Vulnerability, immunity and intervention

Yiyin Chen et al.

Summary: The COVID-19 pandemic originating from Wuhan in December 2019 has had far-reaching health and socioeconomic impacts worldwide. The disease caused by SARS-CoV-2 is highly heterogeneous, with age, gender, and comorbidities playing key roles in disease severity and outcomes. Aging and dysregulation of immune function are thought to contribute to the increased vulnerability of older adults to severe COVID-19. Further research on immune responses to SARS-CoV-2 infection, particularly in different age groups, is crucial for understanding disease heterogeneity and developing effective vaccines.

AGEING RESEARCH REVIEWS (2021)

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Review Allergy

Risk factors for severe and critically ill COVID-19 patients: A review

Ya-dong Gao et al.

Summary: The severity factors of COVID-19 include age, gender, underlying health conditions such as hypertension, diabetes, obesity, and immunodeficiency, which may lead to complications like acute kidney injury. Various laboratory indicators and parameters can help monitor disease progression, while socioeconomic factors, lifestyle, and quality of healthcare also play a role in individual outcomes.

ALLERGY (2021)

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Review Pediatrics

Why is COVID-19 less severe in children? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections

Petra Zimmermann et al.

Summary: The severity of COVID-19 differs between children and adults, with factors that put adults at higher risk and factors that protect children being the main reasons for this difference.

ARCHIVES OF DISEASE IN CHILDHOOD (2021)

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Article Medicine, Research & Experimental

Hypertension, Diabetes and Obesity, Major Risk Factors for Death in Patients with COVID-19 in Mexico

Jorge Escobedo-de la Pena et al.

Summary: The study investigated the main clinical characteristics of COVID-19 in a major social security institution in Mexico, finding that major cardiovascular risk factors and other comorbidities increased the risk of mortality in patients with COVID-19. Factors such as age, sex, obesity, hypertension, and diabetes were associated with an increased case fatality rate.

ARCHIVES OF MEDICAL RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Sex differences in immune responses to SARS-CoV-2 in patients with COVID-19

Guolian Zhao et al.

Summary: The study found significant differences between sexes in COVID-19 patients, with males showing higher disease severity, higher monocyte counts, CRP and ALT levels, and increased CD8(+) T cell proportions. Independent of estrogen levels, decreased CD4(+) T cell proportions were observed in males and severe cases.

BIOSCIENCE REPORTS (2021)

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Article Infectious Diseases

Dynamic changes in lymphocyte subsets and parallel cytokine levels in patients with severe and critical COVID-19

Yangli Liu et al.

Summary: A sustained decrease in lymphocyte subsets, especially CD4(+) T cells and NK cells, interacting with proinflammatory cytokine storms was associated with severe disease and poor prognosis in COVID-19.

BMC INFECTIOUS DISEASES (2021)

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Editorial Material Immunology

The interplay between dendritic cells and CD8 T lymphocytes is a crucial component of SARS-CoV-2 immunity

Jonas Buttenschoen et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

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Article Immunology

Lymphocyte subsets early predict mortality in a large series of hospitalized COVID-19 patients in Spain

S. Cantenys-Molina et al.

Summary: In this Spanish series, decreased counts of CD4(+) and CD8(+) T cells with an increase in NK lymphocytes at admission were prognostic factors of death in COVID-19 patients. Even in patients with normal or mildly reduced levels of lymphocytes, imbalanced lymphocyte subpopulations were early indicators of in-hospital mortality.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2021)

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Review Biochemistry & Molecular Biology

Mesenchymal stromal cells to fight SARS-CoV-2: Taking advantage of a pleiotropic therapy

Ines Barros et al.

Summary: This review discusses the possible use of Mesenchymal Stromal Cells (MSC) as a treatment in SARS-CoV-2-infected patients, highlighting the benefits and concerns of this cellular therapy. Preliminary studies have shown promising results of MSC therapy in COVID-19 patients, although further investigational studies are required to determine its efficacy. The United States Food and Drug Administration (FDA) has authorized the compassionate use of MSC in severe SARS-CoV-2 patients with Acute Respiratory Distress Syndrome (ARDS) and a poor prognosis.

CYTOKINE & GROWTH FACTOR REVIEWS (2021)

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Article Geriatrics & Gerontology

COVID-19 in older adults: What are the differences with younger patients?

Ana B. Gomez-Belda et al.

Summary: Older adults with COVID-19 show more atypical symptoms, complications and higher mortality. Oxygen saturation <= 93% on admission is a predictive factor of death.

GERIATRICS & GERONTOLOGY INTERNATIONAL (2021)

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Review Medicine, Research & Experimental

An integrative look at SARS-CoV-2 (Review)

Miguel A. Ortega et al.

Summary: SARS-CoV-2, the etiological agent of COVID-19 pandemic, shows higher infectivity and mortality compared to previous coronaviruses. Its aggressive nature stems from its ability to easily infect and spread through interaction with human ACE-2 receptor. The diverse patient responses highlight the importance of immune system function, with overactive responses potentially leading to severe cases. Developing therapies and vaccines to regulate immune response will be crucial in managing clinical outcomes and reducing transmission of the virus.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2021)

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Article Immunology

COVID-19 convalescent plasma composition and immunological effects in severe patients

Yeny Acosta-Ampudia et al.

Summary: Convalescent plasma treatment for severe COVID-19 patients showed improvement in immune response and metabolic status, suggesting promising therapeutic implications for further studies.

JOURNAL OF AUTOIMMUNITY (2021)

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Article Medicine, Research & Experimental

Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection

Jacob K. Files et al.

Summary: SARS-CoV-2 infection leads to a prolonged period of immune dysregulation, with increased activation and exhaustion markers in T cells and B cells in both hospitalized and nonhospitalized individuals. The changes in T cell activation/exhaustion positively correlate with age, and severely infected individuals exhibited higher expression of activation and exhaustion markers.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Cell Biology

B cell analysis in SARS-CoV-2 versus malaria: Increased frequencies of plasmablasts and atypical memory B cells in COVID-19

Nils H. Wildner et al.

Summary: This study utilized 16-color flow cytometry analysis to investigate peripheral B cells in patients with SARS-CoV-2 infection or acute Plasmodium falciparum malaria. The results showed an increase in atypical memory B cells and plasmablasts in these patients, along with changes in specific protein expression on the plasmablasts. These changes were positively correlated with inflammatory markers in COVID-19 patients.

JOURNAL OF LEUKOCYTE BIOLOGY (2021)

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Article Multidisciplinary Sciences

Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity

Egle Kvedaraite et al.

Summary: This study found that COVID-19 patients experience a redistribution of monocyte subsets towards intermediate monocytes and a general decrease in circulating dendritic cells. Severe disease is associated with the appearance of monocytic myeloid-derived suppressor cell-like cells and a higher frequency of pre-DC2. The phenotypic alterations in mononuclear phagocytes are cell-lineage-specific and linked to the response against SARS-CoV-2 or COVID-19 severity.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Multidisciplinary Sciences

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

Jennifer M. Dan et al.

Summary: Different components of immune memory to SARS-CoV-2 exhibit distinct kinetics, with antibodies and spike-specific memory B cells remaining relatively stable over 6 months, while CD4(+) T cells and CD8(+) T cells declining with a half-life of 3 to 5 months after infection.

SCIENCE (2021)

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Review Respiratory System

Are mesenchymal stem cells and derived extracellular vesicles valuable to halt the COVID-19 inflammatory cascade? Current evidence and future perspectives

Marta Monguio-Tortajada et al.

THORAX (2021)

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Review Immunology

T Cells: Warriors of SARS-CoV-2 Infection

Paola de Candia et al.

Summary: Severe infection with SARS-CoV-2 is characterized by massive cytokine release and T cell loss. The exaggerated host immune response, possibly dependent on T cell immunological memory, may significantly contribute to immunopathology and massive collateral damage in COVID-19 patients, especially in adults compared with children.

TRENDS IN IMMUNOLOGY (2021)

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Letter Medicine, Research & Experimental

Double-blind, randomized, controlled, trial to assess the efficacy of allogenic mesenchymal stromal cells in patients with acute respiratory distress syndrome due to COVID-19 (COVID-AT): A structured summary of a study protocol for a randomised controlled trial

Concepcion Payares-Herrera et al.

TRIALS (2021)

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Article Virology

A novel ratio of CD8+:B-cells as a prognostic marker of coronavirus disease 2019 patient progression and outcome

Maria G. Detsika et al.

Summary: The study analyzed immune responses in critically ill COVID-19 patients and found that the CD8(+):B cells ratio was significantly lower in intubated patients compared to non-intubated, and correlated with disease severity and outcome. This ratio may serve as a useful prognostic marker.

VIROLOGY (2021)

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Review Cell & Tissue Engineering

Overview of current adipose-derived stem cell (ADSCs) processing involved in therapeutic advancements: flow chart and regulation updates before and after COVID-19

Loubna Mazini et al.

Summary: Adipose-derived stem cells have low immunogenicity and various self-renewal abilities, can differentiate into different tissue-specific progenitors, migrate into damaged sites, and act through autocrine and paracrine pathways. However, the lack of standardization protocols and discrepancies in cell outcomes and engraftment pose limitations on their widespread use.

STEM CELL RESEARCH & THERAPY (2021)

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Article Cell & Tissue Engineering

Umbilical cord mesenchymal stem cells for COVID-19 acute respiratory distress syndrome: A double-blind, phase 1/2a, randomized controlled trial

Giacomo Lanzoni et al.

Summary: The study confirmed safety of UC-MSC infusions in patients with COVID-19 ARDS. By reducing inflammatory cytokines, significant improvement was observed in UC-MSC-treated patients on day 6. The treatment markedly increased patient survival rate, SAE-free survival, and time to recovery.

STEM CELLS TRANSLATIONAL MEDICINE (2021)

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Review Physiology

Aging, Immunity, and COVID-19: How Age Influences the Host Immune Response to Coronavirus Infections?

Varnica Bajaj et al.

Summary: The novel coronavirus has greatly impacted the world with over 72 million cases and 1.6 million deaths, mostly affecting the elderly population. Aging leads to changes in the immune system, making elderly individuals more susceptible to infections and less responsive to vaccines. Understanding age-related immune system changes is crucial for managing infectious diseases like COVID-19.

FRONTIERS IN PHYSIOLOGY (2021)

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Review Immunology

Sex Differences in Immunity: Implications for the Development of Novel Vaccines Against Emerging Pathogens

Anahita Fathi et al.

Summary: Vaccines are crucial in saving lives, but responses to vaccination may vary based on factors like gender and age. As COVID-19 vaccines are being developed, the gender-specific differences in vaccine response need more attention and research.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Cell Biology

Clinical characteristics and peripheral immunocyte subsets alteration of 85 COVID-19 deaths

Liangkun Xiong et al.

Summary: This study retrospectively evaluated clinical and immunological characteristics of patients who died of COVID-19, identifying risk factors such as increased D-dimer, decreased CD4 + T cells, and elevated neutrophils for mortality. Decreased CD4 + T cell count was found to be a risk factor for severe disease and death in COVID-19 patients.

AGING-US (2021)

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Article Biochemistry & Molecular Biology

Maturation and persistence of the anti-SARS-CoV-2 memory B cell response

Aurelien Sokal et al.

Summary: Memory B cells play a crucial role in host defense against SARS-CoV-2, with distinct B cell clone responses to the virus contributing to long-lasting immune protection. The study also highlights the significance of somatic mutations in the variable region genes of memory B cells over time, indicating continued maturation and long-term immune memory post-infection.

CELL (2021)

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Review Respiratory System

COVID-19-pathogenesis and immunological findings across the clinical manifestation spectrum

Rita Carsetti et al.

Summary: The wide range of clinical manifestations of COVID-19 highlights the important role of individual immune response to SARS-CoV-2. Impairment of interferon responses may lead to severe COVID-19 with reduced antiviral activity. Further studies are needed to fully understand the human immune response and potential implications for tailored vaccination strategies.

CURRENT OPINION IN PULMONARY MEDICINE (2021)

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Article Infectious Diseases

B cell depletion and signs of sepsis-acquired immunodeficiency in bone marrow and spleen of COVID-19 deceased

Jana Ihlow et al.

Summary: The study revealed that severe COVID-19 pneumonia with bacterial infection may lead to sepsis-related immunodeficiency. Additionally, lymphocytopenia in COVID-19 patients is accompanied by B cell depletion in hematopoietic tissue, which could impact the durability of the humoral immune response to SARS-CoV-2.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

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Review Biochemistry & Molecular Biology

The Role of Immunogenetics in COVID-19

Fanny Pojero et al.

Summary: COVID-19, induced by SARS-CoV-2, manifests a spectrum of clinical symptoms, with genetic variants in immunogenetics potentially playing a significant role in disease evolution and treatment. Researchers are investigating the impact of these variants on disease progression, aiming to improve patient outcomes through personalized therapeutic strategies and drug repurposing.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Multidisciplinary Sciences

Switched and unswitched memory B cells detected during SARS-CoV-2 convalescence correlate with limited symptom duration

Krista L. Newell et al.

Summary: Memory B cell frequency in convalescent COVID-19 subjects is significantly correlated with the duration of symptoms, indicating its importance as a critical indicator of disease resolution. IgM+ memory B cells may play a crucial role in SARS-CoV-2 immunity.

PLOS ONE (2021)

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Article Multidisciplinary Sciences

Innate cell profiles during the acute and convalescent phase of SARS-CoV-2 infection in children

Melanie R. Neeland et al.

Summary: Children with mild SARS-CoV-2 infection exhibit reduced subsets of circulating monocytes, dendritic cells, and natural killer cells during the acute phase, along with an increase in activated neutrophils. In contrast, infected adults show a reduction in non-classical monocytes. Both children and adults exposed to SARS-CoV-2, even if PCR testing is negative, display increased proportions of low-density neutrophils up to 7 weeks post exposure. This study provides insights into the differences in innate immune responses between children and adults during SARS-CoV-2 infection.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19

Adam K. Wheatley et al.

Summary: The durability of infection-induced SARS-CoV-2 immunity has major implications for reinfection and vaccine development. Antibody, B cell, and T cell responses decline over the first 4 months post-infection, while S-specific IgG(+) memory B cells consistently accumulate. The study suggests that natural infection may only provide transient protection at a population level, highlighting the need for more immunogenic and durable vaccines.

NATURE COMMUNICATIONS (2021)

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Article Cell & Tissue Engineering

Mesenchymal stem cells derived from perinatal tissues for treatment of critically ill COVID-19-induced ARDS patients: a case series

Seyed-Mohammad Reza Hashemian et al.

Summary: This study investigated the safety and effectiveness of multiple high-dose infusions of MSCs derived from placenta and umbilical cord in critically ill COVID-19-induced ARDS patients. Some patients showed significant improvement in respiratory distress and reduction in inflammatory markers after cell infusions.

STEM CELL RESEARCH & THERAPY (2021)

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Article Immunology

Increased sCD163 and sCD14 Plasmatic Levels and Depletion of Peripheral Blood Pro-Inflammatory Monocytes, Myeloid and Plasmacytoid Dendritic Cells in Patients With Severe COVID-19 Pneumonia

Maria Antonella Zingaropoli et al.

Summary: Elevated levels of sCD163 and sCD14 were observed in COVID-19 patients, particularly in those developing ARDS, with correlations to typical inflammatory markers. This suggests their potential use in assessing disease progression risk. Lower percentages of monocytes and DCs in COVID-19 patients, especially in the ARDS group, indicate their role in disease severity.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Critical Care Medicine

Mesenchymal Stem Cell Therapy for Severe COVID-19 ARDS

Helene Haeberle et al.

Summary: The study shows that MSC infusion is a safe treatment for severe COVID-19-induced ARDS, improving pulmonary function and overall outcome. Patients receiving MSC treatment had higher survival rates and lower lung injury scores compared to the control group.

JOURNAL OF INTENSIVE CARE MEDICINE (2021)

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Review Cell Biology

Mesenchymal Stem Cell-Derived Exosomes Exhibit Promising Potential for Treating SARS-CoV-2-Infected Patients

Alok Raghav et al.

Summary: The novel coronavirus SARS-CoV-2 has caused the COVID-19 pandemic, leading to global economic recession and crisis. Mesenchymal stem cell-derived exosomes show promise as a treatment for COVID-19, but there is limited knowledge on their use in SARS-CoV-2.

CELLS (2021)

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Review Cell Biology

Thymic Aging May Be Associated with COVID-19 Pathophysiology in the Elderly

Weikan Wang et al.

Summary: COVID-19 severity in the elderly is linked to decreased antiviral immune function and excessive inflammation, involving T cell aging and chronic inflammatory conditions. Understanding how age-related changes impact disease severity is crucial for developing effective strategies to enhance immune responses in the elderly.

CELLS (2021)

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Article Immunology

Prolonged evolution of the human B cell response to SARS-CoV-2 infection

Mrunal Sakharkar et al.

Summary: The study on the kinetics and evolution of the human B cell response to SARS-CoV-2 infection revealed that serum neutralizing antibody responses declined rapidly, while spike-specific IgG(+) memory B cells remained stable or increased over time. The research also showed evidence for prolonged antibody affinity maturation and the impact of mutations in the S protein on the neutralizing antibody response.

SCIENCE IMMUNOLOGY (2021)

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Review Immunology

Immune Response to SARS-CoV-2 Infection in Obesity and T2D: Literature Review

Jorge Perez-Galarza et al.

Summary: Metabolic diseases such as obesity and diabetes can disrupt the balance of the immune system, leading to stronger immune responses in patients infected with SARS-CoV-2, increasing their risk of severe and fatal outcomes.

VACCINES (2021)

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Article Medicine, General & Internal

Sex Differences on Clinical Characteristics, Severity, and Mortality in Adult Patients With COVID-19: A Multicentre Retrospective Study

Jing Sha et al.

Summary: The study found that age and sex have a significant interaction in COVID-19 in-hospital mortality, with male sex being an independent risk factor. While female mortality in COVID-19 is lower than male, it may not be directly related to the effect of estrogen. Further research is needed to identify sex differences and mechanisms involved in COVID-19.

FRONTIERS IN MEDICINE (2021)

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Article Oncology

Evaluation of the safety and efficacy of using human menstrual blood-derived mesenchymal stromal cells in treating severe and critically ill COVID-19 patients: An exploratory clinical trial

Xiaowei Xu et al.

Summary: A study showed that using menstrual blood-derived MSCs to treat severe COVID-19 patients can reduce mortality, improve dyspnea, and increase oxygen saturation levels. This MSC-based therapy may be a promising alternative for treating severe COVID-19.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

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Review Cell Biology

SARS CoV2 infection _The longevity study perspectives

Domenico Lio et al.

Summary: COVID-19 exhibits a wide range of clinical outcomes, with elderly males in Italy being the most susceptible group, although some individuals show surprising resistance.

AGEING RESEARCH REVIEWS (2021)

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Article Immunology

Increased B-cell activity with consumption of activated monocytes in severe COVID-19 patients

Igor Kos et al.

Summary: The study compared the immune status of COVID-19 patients and found significant cellular immune abnormalities in severe patients, with the reduced B/T8-cell ratio and decreased rate of activated monocytes being important indicators related to death.

EUROPEAN JOURNAL OF IMMUNOLOGY (2021)

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Review Biochemistry & Molecular Biology

Type I and III interferon responses in SARS-CoV-2 infection

You-Me Kim et al.

Summary: Researchers have reviewed how SARS-CoV-2 manipulates the immune system by inhibiting host IFN responses, leading to delayed and exaggerated inflammation, which contributes to the severity of COVID-19. Further investigations are needed to better understand the mechanisms behind these immune system dysfunctions caused by the virus.

EXPERIMENTAL AND MOLECULAR MEDICINE (2021)

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Article Medicine, Research & Experimental

Durable SARS-CoV-2 B cell immunity after mild or severe disease

Clinton O. Ogega et al.

Summary: Research has shown that individuals infected with SARS-CoV-2 develop S-RBD-specific, class-switched rMBCs, regardless of disease severity. This provides evidence for sustained B cell-mediated immunity against the virus.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Immunology

Activating Killer-Cell Immunoglobulin-Like Receptors Are Associated With the Severity of Coronavirus Disease 2019

Enrique Bernal et al.

Summary: This study investigates the role of killer cell immunoglobulin-like receptor (KIR)/human leukocyte antigen class-I (HLA-I) interactions in the susceptibility and severity of COVID-19. Results show a distinct immunophenotype of NKcs and specific KIR/ligand interactions associated with disease severity, suggesting a crucial role of NKcs in the clinical variability of COVID-19.

JOURNAL OF INFECTIOUS DISEASES (2021)

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Review Cell Biology

Effects of mesenchymal stromal cell-derived extracellular vesicles in acute respiratory distress syndrome (ARDS): Current understanding and future perspectives

Yue Su et al.

Summary: Acute respiratory distress syndrome (ARDS) can be treated with extracellular vesicles derived from mesenchymal stromal cells (MSC-EVs), which contain beneficial molecules to coordinate immune responses and aid in repairing lung damage. However, there are still challenges in applying MSC-EVs in clinical settings.

JOURNAL OF LEUKOCYTE BIOLOGY (2021)

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Review Cell & Tissue Engineering

Medical progress: Stem cells as a new therapeutic strategy for COVID-19

Claudia Musial et al.

Summary: The coronavirus family is divided into four subfamilies, with SARS-CoV-2 belonging to the beta-coronavirus group. Current treatments for COVID-19 include the use of corticosteroids, antiviral drugs, antibiotics, as well as mesenchemical stem cells (MSCs). MSCs have been shown to have immunomodulatory effects and are being researched for potential use in improving outcomes for COVID-19 patients.

STEM CELL RESEARCH (2021)

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Article Microbiology

Sex- and age-specific clinical and immunological features of coronavirus disease 2019

Shengwei Jin et al.

Summary: The study revealed diverse clinical and immunological responses to COVID-19 infection based on sex and age categories. Female patients showed milder disease severity, negative associations with inflammatory responses, and liver damage. On the other hand, older patients exhibited compromised immune responses, negative associations with CD8(+) T cell count, but positive associations with inflammatory responses and liver damage.

PLOS PATHOGENS (2021)

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Article Biology

Seroconversion stages COVID19 into distinct pathophysiological states

Matthew D. Galbraith et al.

Summary: COVID19 is a heterogeneous medical condition involving various underlying pathophysiological processes, limiting the ability to target therapies for patients. A multi-omics analysis revealed that seroconversion status could be used as a biosignature to guide therapeutic interventions and analyze clinical trial results.

ELIFE (2021)

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Article Cell Biology

Immune memory in convalescent patients with asymptomatic or mild COVID-19

Quan-Xin Long et al.

Summary: This study evaluated the durability of protective immune responses in individuals recovered from asymptomatic or symptomatic SARS-CoV-2 infection approximately 6 months prior. Memory B cell response specific to the RBD of SARS-CoV-2 was relatively low, while T cell responses were observed in individuals recovered from COVID-19, and cross-reactive T cell responses were detected in healthy controls.

CELL DISCOVERY (2021)

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Review Immunology

Mesenchymal stromal/stem cells (MSCs) and MSC-derived extracellular vesicles in COVID-19-induced ARDS: Mechanisms of action, research progress, challenges, and opportunities

Susan Moradinasab et al.

Summary: The emergence of novel coronavirus in Wuhan in 2019 has caused a worldwide pandemic, leading to an unprecedented public health crisis. Mesenchymal stromal/stem cells (MSCs) have shown therapeutic potential against COVID-19 due to their immunomodulatory and anti-inflammatory effects, but challenges like malignant transformation and coagulopathy need to be addressed for successful application. Research has shown promising results in the use of MSCs for acute respiratory distress syndrome (ARDS) and viral infections, suggesting MSC therapy could be a valuable approach in treating COVID-19.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Immunology

Immunological and inflammatory profiles during acute and convalescent phases of severe/critically ill COVID-19 patients

Qigao Chen et al.

Summary: The study found that levels of IP-10, MCP-1, MIG, IL-6, and IL-10 were significantly higher in critically ill/severe COVID-19 patients, while CD8 T cells in these patients showed high levels of cytotoxic granules and hyperactivation. Additionally, there were reductions in the cytotoxic potential of NK cells, as well as in the frequencies of myeloid dendritic cells and plasmacytoid dendritic cells in severe and critical COVID-19 patients.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Review Biochemistry & Molecular Biology

Potential of Mesenchymal Stem Cells in the Rejuvenation of the Aging Immune System

Genieve Ee Chia Yeo et al.

Summary: The rapid growth of the geriatric population is accompanied by an increased prevalence of age-associated diseases, leading to the deterioration of the immune system known as immunosenescence. This review highlights the characteristics of an aging immune system, such as dysregulation of immune cell production and functioning, and the potential of mesenchymal stem cell transplantation as a promising solution for halting immunosenescence.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Cell & Tissue Engineering

Updates on clinical trials evaluating the regenerative potential of allogenic mesenchymal stem cells in COVID-19

Dhavan Sharma et al.

Summary: Allogenic MSC infusion is safe and effective in COVID-19 patients with ARDS, reducing inflammatory cytokines and improving patient survival and recovery time, supporting further investigation into larger clinical trials for this group of patients.

NPJ REGENERATIVE MEDICINE (2021)

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Article Medicine, Research & Experimental

Alterations in T and B cell function persist in convalescent COVID-19 patients

Halima A. Shuwa et al.

Summary: The study describes the phenotypic and functional characteristics of B and T cells in hospitalized COVID-19 patients during acute disease and at 3-6 months of convalescence. The alterations in B cell subsets observed in acute COVID-19 patients were largely recovered in convalescent patients, while T cells from convalescent patients displayed continued alterations. Different subgroups of convalescent patients were identified based on distinct lymphocyte phenotypes, with one subgroup associated with poorer clinical outcomes.

MED (2021)

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Article Cell Biology

Long-term persistence of RBD+ memory B cells encoding neutralizing antibodies in SARS-CoV-2 infection

Arunasingam Abayasingam et al.

Summary: The study suggests that while neutralizing antibodies in plasma may decline, the neutralizing capacity can still be maintained in the memory B cell repertoire. These memory B cells are capable of continuously producing antibodies with neutralizing capacity against SARS-CoV-2.

CELL REPORTS MEDICINE (2021)

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Article Immunology

Single Cell Transcriptomic Re-analysis of Immune Cells in Bronchoalveolar Lavage Fluids Reveals the Correlation of B Cell Characteristics and Disease Severity of Patients with SARS-CoV-2 Infection

Chae Won Kim et al.

Summary: This study found that B cells and macrophages in severe COVID-19 patients were more activated and expressed higher levels of inflammatory markers, suggesting a potential association between the characteristics of these cells and the severity of the infection.

IMMUNE NETWORK (2021)

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Article Medicine, Research & Experimental

Persistence of SARS-CoV-2-specific B and T cell responses in convalescent COVID-19 patients 6-8 months after the infection

Natalia Sherina et al.

Summary: The study shows that 85% of samples from COVID-19 patients had anti-SARS-CoV-2 antibodies within 4 weeks of symptom onset, while specific IgG antibodies and plasma neutralizing activities remained relatively stable up to 6 months after diagnosis. 80% of samples collected at 6-8 months after symptom onset still had anti-SARS-CoV-2 IgG antibodies, and specific memory B and T cell responses continued to develop and persist.

MED (2021)

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Article Biochemistry & Molecular Biology

Dynamic blood single-cell immune responses in patients with COVID-19

Lulin Huang et al.

Summary: The study revealed dynamic changes in blood immune responses against SARS-CoV-2 in patients with COVID-19, with changes in cell types and recovery of immune pathways after improvement. The important role of the IFN-I pathway in the immune response of COVID-19 was highlighted, along with the development of specific immune responses against SARS-CoV-2 antigens in patients.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Letter Geriatrics & Gerontology

Coronavirus Disease (COVID-19): A Perspective from Immunosenescence

Miguel Genebat et al.

AGING AND DISEASE (2021)

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Article Cell & Tissue Engineering

Proposed Mechanisms of Targeting COVID-19 by Delivering Mesenchymal Stem Cells and Their Exosomes to Damaged Organs

Elham Jamshidi et al.

Summary: In the face of the unprecedented challenge presented by the COVID-19 pandemic, developing effective treatments using MSCs and their exosomes, which have been shown to possess therapeutic potential through immunomodulation and organ repair, is crucial. Research focus has also been on the delivery routes and modifications of MSCs for safe and effective administration in COVID-19. Recent advances in clinical trials suggest promising therapeutic potential of MSCs and their exosomes in treating COVID-19.

STEM CELL REVIEWS AND REPORTS (2021)

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Article Geriatrics & Gerontology

COVID-19 mortality risk factors in older people in a long-term care center

Eva Heras et al.

Summary: Male gender, low Barthel index, and lymphocytopenia are independent risk factors for COVID-19 mortality in institutionalized older patients in long-term care nursing homes. Treatment with hydroxychloroquine and azithromycin was associated with lower mortality in these patients.

EUROPEAN GERIATRIC MEDICINE (2021)

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Article Immunology

Leukocyte trafficking to the lungs and beyond: lessons from influenza for COVID-19

Ronen Alon et al.

Summary: The understanding of COVID-19 clinical manifestations requires knowledge of how immune cells are recruited to virus-infected lungs and how this recruitment varies among individuals. The orchestration of leukocyte trafficking to respiratory system is controlled by specific molecules, which can lead to pathological complications when uncontrolled. The incomplete understanding of trafficking signals in response to SARS-CoV-2 infection calls for further research for potential therapeutic interventions.

NATURE REVIEWS IMMUNOLOGY (2021)

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Article Cell & Tissue Engineering

'Primed' Mesenchymal Stem Cells: a Potential Novel Therapeutic for COVID19 Patients

Syed Shadab Raza et al.

Summary: The COVID19 pandemic is designated a public health crisis by WHO and is impacting countries worldwide. Using 'Primed' Mesenchymal Stem Cells (MSCs) as a therapeutic alternative may help improve responses in COVID19 patients.

STEM CELL REVIEWS AND REPORTS (2021)

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Article Immunology

Pattern of circulating SARS-CoV-2-specific antibody-secreting and memory B-cell generation in patients with acute COVID-19

Maria Byazrova et al.

Summary: The study analyzed the generation of plasmablasts and RBD-specific memory B cells in patients during the acute phase of COVID-19. The activation and proliferation of Bmem cells were induced which led to the generation of plasmablast phenotypic cells and RBD-specific ASCs. Additionally, it was found that SARS-CoV-2-specific Bmem cells are generated during the acute phase of COVID-19, providing a basis for further studies on the longevity of SARS-CoV-2-specific B-cell memory.

CLINICAL & TRANSLATIONAL IMMUNOLOGY (2021)

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Article Immunology

Intrafamilial Exposure to SARS-CoV-2 Associated with Cellular Immune Response without Seroconversion, France

Floriane Gallais et al.

Summary: The study found that all confirmed COVID-19 patients had SARS-CoV-2 specific antibodies and T-cell responses lasting up to 102 days after symptom onset, while their contacts remained seronegative but 6 of them reported COVID-19 symptoms within a median of 7 days and 4 of them had positive SARS-CoV-2 specific T-cell responses lasting up to 93 days after infection.

EMERGING INFECTIOUS DISEASES (2021)

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Review Geriatrics & Gerontology

Inflammation and the Alteration of B-Cell Physiology in Aging

Magdalena Hagen et al.

GERONTOLOGY (2020)

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Review Cell Biology

Aging, sex, inflammation, frailty, and CMV and HIV infections

Sean X. Leng et al.

CELLULAR IMMUNOLOGY (2020)

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Review Genetics & Heredity

Widespread sex dimorphism in aging and age-related diseases

Nirmal K. Sampathkumar et al.

HUMAN GENETICS (2020)

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Article Immunology

CD28 and CD57 define four populations with distinct phenotypic properties within human CD8+ T cells

Luca Pangrazzi et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2020)

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Letter Critical Care Medicine

Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China

Qiurong Ruan et al.

INTENSIVE CARE MEDICINE (2020)

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Article Medicine, General & Internal

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China

Dawei Wang et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Article Virology

Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS

Yushun Wan et al.

JOURNAL OF VIROLOGY (2020)

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Article Medicine, General & Internal

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

Nanshan Chen et al.

LANCET (2020)

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Article Medicine, General & Internal

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang et al.

LANCET (2020)

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Article Medicine, General & Internal

Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia

Qun Li et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Multidisciplinary Sciences

Sexual-dimorphism in human immune system aging

Eladio J. Marquez et al.

NATURE COMMUNICATIONS (2020)

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Review Medicine, General & Internal

MSC Based Therapies-New Perspectives for the Injured Lung

Judith Behnke et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Review Oncology

The Generation and Identity of Human Myeloid-Derived Suppressor Cells

Caroline Bergenfelz et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Medicine, General & Internal

The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application

Stephen A. Lauer et al.

ANNALS OF INTERNAL MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

Alba Grifoni et al.

CELL (2020)

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Article Biochemistry & Molecular Biology

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann et al.

CELL (2020)

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Editorial Material Immunology

Functional exhaustion of antiviral lymphocytes in COVID-19 patients

Meijuan Zheng et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

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Article Medicine, General & Internal

Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province

Kui Liu et al.

CHINESE MEDICAL JOURNAL (2020)

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Editorial Material Pharmacology & Pharmacy

Extracellular vesicles from mesenchymal stem cells as a Covid-19 treatment

Lorraine O'Driscoll

DRUG DISCOVERY TODAY (2020)

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Article Cardiac & Cardiovascular Systems

Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin-angiotensin-aldosterone inhibitors

Iziah E. Sama et al.

EUROPEAN HEART JOURNAL (2020)

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Letter Respiratory System

Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study

Rong-Hui Du et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

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Editorial Material Biotechnology & Applied Microbiology

Adipose-derived stromal stem cells (ASCs) as a new regenerative immediate therapy combating coronavirus (COVID-19)-induced pneumonia

Pietro Gentile et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2020)

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Article Critical Care Medicine

Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study

Xiaobo Yang et al.

Lancet Respiratory Medicine (2020)

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Article Allergy

Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan

Xiaochen Li et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Article Allergy

Elevated levels of IL-6 and CRP predict the need for mechanical ventilation in COVID-19

Tobias Herold et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Article Medicine, Research & Experimental

Clinical and immunological features of severe and moderate coronavirus disease 2019

Guang Chen et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Article Multidisciplinary Sciences

A protocol for rapid monocyte isolation and generation of singular human monocyte-derived dendritic cells

Thaize Quiroga Chometon et al.

PLOS ONE (2020)

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Article Urology & Nephrology

COVID-19 and the male susceptibility: the role of ACE2, TMPRSS2 and the androgen receptor

G. Mjaess et al.

PROGRES EN UROLOGIE (2020)

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Letter Infectious Diseases

Lymphopenic community acquired pneumonia as signature of severe COVID-19 infection

Jesus F. Bermejo-Martin et al.

JOURNAL OF INFECTION (2020)

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Article Immunology

T-Cell Subset Counts in Peripheral Blood Can Be Used as Discriminatory Biomarkers for Diagnosis and Severity Prediction of Coronavirus Disease 2019

Mei Jiang et al.

JOURNAL OF INFECTIOUS DISEASES (2020)

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Article Immunology

Characteristics of Peripheral Lymphocyte Subset Alteration in COVID-19 Pneumonia

Fan Wang et al.

JOURNAL OF INFECTIOUS DISEASES (2020)

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Review Cell Biology

On the origin of low-density neutrophils

Marwan Hassani et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2020)

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Editorial Material Multidisciplinary Sciences

Cytokine release syndrome in severe COVID-19

John B. Moore et al.

SCIENCE (2020)

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Review Virology

Predictors of mortality in hospitalized COVID-19 patients: A systematic review and meta-analysis

Wenjie Tian et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

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Article Cell & Tissue Engineering

Exosomes Derived from Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID-19

Vikram Sengupta et al.

STEM CELLS AND DEVELOPMENT (2020)

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Review Nutrition & Dietetics

Vitamin D's Effect on Immune Function

Pieter-Jan Martens et al.

NUTRIENTS (2020)

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Article Cell & Tissue Engineering

Intravenous infusion of human umbilical cord Wharton's jelly-derived mesenchymal stem cells as a potential treatment for patients with COVID-19 pneumonia

Yingxin Zhang et al.

STEM CELL RESEARCH & THERAPY (2020)

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Article Microbiology

Sex-specific clinical characteristics and prognosis of coronavirus disease-19 infection in Wuhan, China: A retrospective study of 168 severe patients

Yifan Meng et al.

PLoS Pathogens (2020)

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Review Medicine, Research & Experimental

Transitional B cells involved in autoimmunity and their impact on neuroimmunological diseases

Yang Zhou et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

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Review Medicine, Research & Experimental

Rationale for the clinical use of adipose-derived mesenchymal stem cells for COVID-19 patients

Christopher J. Rogers et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

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Review Geriatrics & Gerontology

The lethal sex gap: COVID-19

Eladio J. Marquez et al.

IMMUNITY & AGEING (2020)

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Article Medicine, General & Internal

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

Fei Zhou et al.

LANCET (2020)

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Review Endocrinology & Metabolism

Impact of sex and gender on COVID-19 outcomes in Europe

Catherine Gebhard et al.

BIOLOGY OF SEX DIFFERENCES (2020)

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Article Infectious Diseases

Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues

Meng-Yuan Li et al.

INFECTIOUS DISEASES OF POVERTY (2020)

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Article Medicine, General & Internal

Sex Differences in Case Fatality Rate of COVID-19: Insights From a Multinational Registry

Mohamad Alkhouli et al.

MAYO CLINIC PROCEEDINGS (2020)

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Article Immunology

Bioinformatic analysis and identi fication of single -stranded RNA sequences recognized by TLR7/8 in the SARS-CoV-2, SARS-CoV, and MERS-CoV genomes

Mario Adan Moreno-Eutimio et al.

MICROBES AND INFECTION (2020)

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Article Biotechnology & Applied Microbiology

Comprehensive Molecular Profiles of Functionally Effective MSC-Derived Extracellular Vesicles in Immunomodulation

Hyemee Kim et al.

MOLECULAR THERAPY (2020)

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Article Immunology

Sestrins induce natural killer function in senescent-like CD8+ T cells

Branca Pereira et al.

NATURE IMMUNOLOGY (2020)

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Article Biochemistry & Molecular Biology

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

Mingfeng Liao et al.

NATURE MEDICINE (2020)

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Review Cell Biology

Mesenchymal Stem Cell-Derived Extracellular Vesicles: Challenges in Clinical Applications

Austin Gowen et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Article Public, Environmental & Occupational Health

Gender Differences in Patients With COVID-19: Focus on Severity and Mortality

Jian-Min Jin et al.

FRONTIERS IN PUBLIC HEALTH (2020)

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Article Endocrinology & Metabolism

Comorbid diabetes and the risk of disease severitytrun or death among 8807 COVID-19 patients in China: A meta-analysis

Li Guo et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2020)

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Article Biochemistry & Molecular Biology

Expansion of myeloid-derived suppressor cells in patients with severe coronavirus disease (COVID-19)

Chiara Agrati et al.

CELL DEATH AND DIFFERENTIATION (2020)

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Article Immunology

Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses

Runhong Zhou et al.

IMMUNITY (2020)

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Article Immunology

Next-Generation Sequencing of T and B Cell Receptor Repertoires from COVID-19 Patients Showed Signatures Associated with Severity of Disease

Christoph Schultheiss et al.

IMMUNITY (2020)

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Review Cell Biology

The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of inflame-aging

Gholam Hossein Meftahi et al.

INFLAMMATION RESEARCH (2020)

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Review Infectious Diseases

Lymphopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A systemic review and meta-analysis

Qianwen Zhao et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

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Article Medicine, Research & Experimental

Transcriptomic analysis of COVID-19 lungs and bronchoalveolar lavage fluid samples reveals predominant B cell activation responses to infection

Eugenio Cavalli et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2020)

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Review Immunology

Remodeling of the Immune Response With Aging: Immunosenescence and Its Potential Impact on COVID-19 Immune Response

Lucas Leite Cunha et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Immunology

The COVID-19 Cytokine Storm; What We Know So Far

Dina Ragab et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Oncology

Clinical study using mesenchymal stem cells for the treatment of patients with severe COVID-19

Lingling Tang et al.

FRONTIERS OF MEDICINE (2020)

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Article Medicine, General & Internal

Presence of Genetic Variants Among Young Men With Severe COVID-19

Caspar I. van der Made et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Review Medicine, General & Internal

COVID-19: Specific and Non-Specific Clinical Manifestations and Symptoms: The Current State of Knowledge

Jacek Baj et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Article Immunology

Comprehensive mapping of immune perturbations associated with severe COVID-19

Leticia Kuri-Cervantes et al.

SCIENCE IMMUNOLOGY (2020)

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Article Immunology

Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19

Jeong Seok Lee et al.

SCIENCE IMMUNOLOGY (2020)

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Review Infectious Diseases

Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: A systematic review and meta-analysis

Leiwen Fu et al.

JOURNAL OF INFECTION (2020)

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Article Infectious Diseases

Coronavirus disease 2019 in elderly patients: Characteristics and prognostic factors based on 4-week follow-up

Lang Wang et al.

JOURNAL OF INFECTION (2020)

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Article Virology

Gendered effects on inflammation reaction and outcome of COVID-19 patients in Wuhan

Lu Qin et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

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Review Cell Biology

SARS-CoV-2, immunosenescence and inflammaging: partners in the COVID-19 crime

Renato Domingues et al.

AGING-US (2020)

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Article Geriatrics & Gerontology

COVID-19, Virology and Geroscience: A Perspective

C. Vellas et al.

JOURNAL OF NUTRITION HEALTH & AGING (2020)

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Article Geriatrics & Gerontology

COVID-19 and Crosstalk With the Hallmarks of Aging

Shabnam Salimi et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2020)

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Review Medicine, General & Internal

COVID-19 and Sex Differences: Mechanisms and Biomarkers

Tu Haitao et al.

MAYO CLINIC PROCEEDINGS (2020)

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Article Medicine, General & Internal

Clinical remission of a critically ill COVID-19 patient treated by human umbilical cord mesenchymal stem cells A case report

Bing Liang et al.

MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

Takuya Sekine et al.

CELL (2020)

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Article Multidisciplinary Sciences

SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

Julian Braun et al.

NATURE (2020)

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Article Biotechnology & Applied Microbiology

COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis

Robert Lorenz Chua et al.

NATURE BIOTECHNOLOGY (2020)

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Article Biochemistry & Molecular Biology

A single-cell atlas of the peripheral immune response in patients with severe COVID-19

Aaron J. Wilk et al.

NATURE MEDICINE (2020)

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Article Multidisciplinary Sciences

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

Divij Mathew et al.

SCIENCE (2020)

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Review Immunology

The interplay between immunosenescence and age-related diseases

Florencia Barbe-Tuana et al.

SEMINARS IN IMMUNOPATHOLOGY (2020)

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Letter Medicine, Research & Experimental

Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration in COVID-19 (REALIST-COVID-19): A structured summary of a study protocol for a randomised, controlled trial

Ellen Gorman et al.

TRIALS (2020)

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Article Multidisciplinary Sciences

Immunological and inflammatory profiles in mild and severe cases of COVID-19

Jin-Wen Song et al.

NATURE COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia

Sara De Biasi et al.

NATURE COMMUNICATIONS (2020)

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Review Cell Biology

Mesenchymal stem cell therapy for acute respiratory distress syndrome: from basic to clinics

Hua Qin et al.

PROTEIN & CELL (2020)

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Article Cell & Tissue Engineering

Current status of mesenchymal stem cell therapy for immune/inflammatory lung disorders: Gleaning insights for possible use inCOVID-19

B. Linju Yen et al.

STEM CELLS TRANSLATIONAL MEDICINE (2020)

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Review Immunology

Implications of Sex Differences in Immunity for SARS-CoV-2 Pathogenesis and Design of Therapeutic Interventions

Madeleine J. Bunders et al.

IMMUNITY (2020)

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Article Medicine, Research & Experimental

Retrospective analysis of clinical characteristics of 405 patients with COVID-19

Ting Zhan et al.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2020)

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Article Medicine, General & Internal

Sex and gender: modifiers of health, disease, and medicine

Franck Mauvais-Jarvis et al.

LANCET (2020)

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Review Medicine, Research & Experimental

Contribution of monocytes and macrophages to the local tissue inflammation and cytokine storm in COVID-19: Lessons from SARS and MERS, and potential therapeutic interventions

Abdollah Jafarzadeh et al.

LIFE SCIENCES (2020)

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Review Medicine, Research & Experimental

The role of cytokine profile and lymphocyte subsets in the severity of coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis

Hamed Akbari et al.

LIFE SCIENCES (2020)

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Article Multidisciplinary Sciences

Sex differences in immune responses that underlie COVID-19 disease outcomes

Takehiro Takahashi et al.

NATURE (2020)

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Article Immunology

Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19

Matthew C. Woodruff et al.

NATURE IMMUNOLOGY (2020)

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Article Multidisciplinary Sciences

Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

Prabhu S. Arunachalam et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

Two distinct immunopathological profiles in autopsy lungs of COVID-19

Ronny Nienhold et al.

NATURE COMMUNICATIONS (2020)

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Article Cell & Tissue Engineering

Treatment of severe COVID-19 with human umbilical cord mesenchymal stem cells

Lei Shu et al.

STEM CELL RESEARCH & THERAPY (2020)

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Review Cell & Tissue Engineering

Mesenchymal stem cell-derived extracellular vesicles alter disease outcomes via endorsement of macrophage polarization

Jiangmei Wang et al.

STEM CELL RESEARCH & THERAPY (2020)

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Review Cell & Tissue Engineering

Potential application of mesenchymal stem cells and their exosomes in lung injury: an emerging therapeutic option for COVID-19 patients

Sara Al-Khawaga et al.

STEM CELL RESEARCH & THERAPY (2020)

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Review Medicine, General & Internal

Incubation period of COVID-19: a rapid systematic review and meta-analysis of observational research

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BMJ OPEN (2020)

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IMMUNITY & AGEING (2020)

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Sex differences in severity and mortality from COVID-19: are males more vulnerable?

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BIOLOGY OF SEX DIFFERENCES (2020)

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Granulocytic Myeloid-Derived Suppressor Cells as Negative Regulators of Anticancer Immunity

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FRONTIERS IN IMMUNOLOGY (2020)

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The Immunomodulatory Effects of Mesenchymal Stem Cells on Regulatory B Cells

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Immunesenescence: A Predisposing Risk Factor for the Development of COVID-19?

Jon Hazeldine et al.

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Article Infectious Diseases

Human Umbilical Cord Mesenchymal Stem Cells for Adjuvant Treatment of a Critically III COVID-19 Patient: A Case Report

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INFECTION AND DRUG RESISTANCE (2020)

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WORLD JOURNAL OF STEM CELLS (2020)

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SARS-CoV-2 infection induces mixed M1/M2 phenotype in circulating monocytes and alterations in both dendritic cell and monocyte subsets

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Depletion of circulating IgM memory B cells predicts unfavourable outcome in COVID-19

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Clinical Characteristics and Immune Responses of 137 Deceased Patients With COVID-19: A Retrospective Study

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Human Mesenchymal Stem Cells: The Present Alternative for High-Incidence Diseases, Even SARS-Cov-2

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B Cell Subsets as Severity-Associated Signatures in COVID-19 Patients

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Different Innate and Adaptive Immune Responses to SARS-CoV-2 Infection of Asymptomatic, Mild, and Severe Cases

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Mesenchymal Stem Cells (MSCs) as a Potential Therapeutic Strategy in COVID-19 Patients: Literature Research

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Rapid generation of durable B cell memory to SARS-CoV-2 spike and nucleocapsid proteins in COVID-19 and convalescence

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Effect of blood analysis and immune function on the prognosis of patients with COVID-19

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I mmunosenescence and Inflammaging: Risk Factors of Severe COVID-19 in Older People

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Early expansion of myeloid-derived suppressor cells inhibits SARS-CoV-2 specific T-cell response and may predict fatal COVID-19 outcome

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Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibody Responses in Coronavirus Disease Patients

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Therapeutic potential of mesenchymal stem cells and their exosomes in severe novel coronavirus disease 2019 (COVID-19) cases

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Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19: a phase 1 clinical trial

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Potential Using of Fat-derived Stromal Cells in the Treatment of Active Disease, and also, in Both Pre- and Post-Periods in COVID-19

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T cell responses in patients with COVID-19

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The trinity of COVID-19: immunity, inflammation and intervention

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Administration of umbilical cord mesenchymal stem cells in patients with severe COVID-19 pneumonia

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Mesenchymal Stem Cell Therapy for COVID-19: Present or Future

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Impact of mesenchymal stem cell senescence on inflammaging

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Adipose-derived mesenchymal stromal cells for the treatment of patients with severe SARS-CoV-2 pneumonia requiring mechanical ventilation. A proof of concept study

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ECLINICALMEDICINE (2020)

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The characteristics and predictive role of lymphocyte subsets in COVID-19 patients

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Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin-angiotensin-aldosterone inhibitors

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Transplantation of ACE2(-) Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia

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Frailty and Rejuvenation with Stem Cells: Therapeutic Opportunities and Clinical Challenges

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PD-1-expressing B cells suppress CD4+ and CD8+ T cells via PD-1/PD-L1-dependent pathway

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Attenuation of frailty in older adults with mesenchymal stem cells

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Neutrophil Diversity in Health and Disease

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The Maintenance of Memory Plasma Cells

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Human Dendritic Cell Subsets, Ontogeny, and Impact on HIV Infection

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Mesenchymal stem versus stromal cells: International Society for Cell & Gene Therapy (ISCT®) Mesenchymal Stromal Cell committee position statement on nomenclature

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Phenotypic and Ig Repertoire Analyses Indicate a Common Origin of IgD-CD27- Double Negative B Cells in Healthy Individuals and Multiple Sclerosis Patients

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Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention

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Myeloid and lymphoid activation markers in AIDS and non-AIDS presenters

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B Cell Dysfunction Associated With Aging and Autoimmune Diseases

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Immunosenescence: the potential role of myeloid-derived suppressor cells (MDSC) in age-related immune deficiency

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Aging and the Immune System: the Impact of Immunosenescence on Viral Infection, Immunity and Vaccine Immunogenicity

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Clinical Use of Mesenchymal Stromal Cells in the Treatment of Acute Graft-versus-Host Disease

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Age and immunity: What is immunosenescence?

Graham Pawelec

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Age-associated distribution of normal B-cell and plasma cell subsets in peripheral blood

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Androgen-Induced Immunosuppression

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Effect of Aging on NK Cell Population and Their Proliferation at Ex Vivo Culture Condition

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Sex Hormones in Acquired Immunity and Autoimmune Disease

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Mesenchymal Stem Cell Therapy for Aging Frailty

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Rejuvenation of mucosal immunosenescence by adipose tissue-derived mesenchymal stem cells

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Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology

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Role of Dendritic Cells in inflammation and Loss of Tolerance in the elderly

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The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy

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Interactions between mesenchymal stem cells and the immune system

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Reduced naive CD8+ T-cell priming efficacy in elderly adults

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slan/M-DC8+ cells constitute a distinct subset of dendritic cells in human tonsils

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Airway Memory CD4+ T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses

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T-cell selection in the thymus: a spatial and temporal perspective

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HIV-1 Infection Results in Increased Frequency of Active and Inflammatory SlanDCs that Produce High Level of IL-1β

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Sex differences in immune responses

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How sex and age affect immune responses, susceptibility to infections, and response to vaccination

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Age-Associated B Cells: A T-bet Dependent Effector with Roles in Protective and Pathogenic Immunity

Kira Rubtsova et al.

JOURNAL OF IMMUNOLOGY (2015)

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Editorial Material Biotechnology & Applied Microbiology

Homing properties of mesenchymal stromal cells

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EXPERT OPINION ON BIOLOGICAL THERAPY (2015)

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Shaping of NK cell subsets by aging

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CURRENT OPINION IN IMMUNOLOGY (2014)

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TNFR2 and IL-12 coactivation enables slanDCs to support NK-cell function via membrane-bound TNF-α

Dejene M. Tufa et al.

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Article Geriatrics & Gerontology

Trafficking phenotype and production of granzyme B by double negative B cells (IgG+IgD-CD27-) in the elderly

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EXPERIMENTAL GERONTOLOGY (2014)

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Virus-Specific Memory CD8 T Cells Provide Substantial Protection from Lethal Severe Acute Respiratory Syndrome Coronavirus Infection

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JOURNAL OF VIROLOGY (2014)

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Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

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The Immunosuppressive Effect of Mesenchymal Stromal Cells on B Lymphocytes Is Mediated by Membrane Vesicles

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CELL TRANSPLANTATION (2013)

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The who's who of T-cell differentiation: Human memory T-cell subsets

Yolanda D. Mahnke et al.

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Human dendritic cell subsets

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IMMUNOLOGY (2013)

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Natural killer cell deficiency

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Human 6-sulfo LacNAc (slan) dendritic cells have molecular and functional features of an important pro-inflammatory cell type in lupus erythematosus

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Human plasmacytoid dendritic cells: from molecules to intercellular communication network

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The effect of age on thymic function

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Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function

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AGING CELL (2012)

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Pivotal role of M-DC8+ monocytes from viremic HIV-infected patients in TNFα overproduction in response to microbial products

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BLOOD (2012)

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Human 6-sulfo LacNAc (slan) dendritic cells are a major population of dermal dendritic cells in steady state and inflammation

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Analysis of in vitro secretion profiles from adipose-derived cell populations

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Stem Cell Transplantation in Amyotrophic Lateral Sclerosis Patients: Methodological Approach, Safety, and Feasibility

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Local Transplantation of Granulocyte Colony-Stimulating Factor-Mobilized Human Peripheral Blood Mononuclear Cells for Unhealing Bone Fractures

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Persistent viral infections and immune aging

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CXCR3 in T cell function

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EXPERIMENTAL CELL RESEARCH (2011)

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Human slan (6-sulfo LacNAc) dendritic cells are inflammatory dermal dendritic cells in psoriasis and drive strong TH17/TH1 T-cell responses

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Critical roles of chemokine receptor CCR10 in regulating memory IgA responses in intestines

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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Natural killer cell responses during viral infections: flexibility and conditioning of innate immunity by experience

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CURRENT OPINION IN VIROLOGY (2011)

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Nomenclature of monocytes and dendritic cells in blood

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BLOOD (2010)

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Human Peripheral Blood B-Cell Compartments: A Crossroad in B-Cell Traffic

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CYTOMETRY PART B-CLINICAL CYTOMETRY (2010)

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T Cell Responses Are Required for Protection from Clinical Disease and for Virus Clearance in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice

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Article Multidisciplinary Sciences

A New Mesenchymal Stem Cell (MSC) Paradigm: Polarization into a Pro-Inflammatory MSC1 or an Immunosuppressive MSC2 Phenotype

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PLOS ONE (2010)

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An in vitro model of differentiation of memory B cells into plasmablasts and plasma cells including detailed phenotypic and molecular characterization

Michel Jourdan et al.

BLOOD (2009)

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CD69 Gene Is Differentially Regulated in T and B Cells Evolutionarily Conserved Promoter-Distal by Elements

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JOURNAL OF IMMUNOLOGY (2009)

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Article Biochemistry & Molecular Biology

Sex differences in the Toll-like receptor-mediated response of plasmacytoid dendritic cells to HIV-1

Angela Meier et al.

NATURE MEDICINE (2009)

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B cells and aging: molecules and mechanisms

Michael P. Cancro et al.

TRENDS IN IMMUNOLOGY (2009)

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1,25-Dihydroxyvitamin D-3 induces CCR10 expression in terminally differentiating human B cells

Aiko-Konno Shirakawa et al.

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TLR7 Ligands induce higher IFN-α production in females

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JOURNAL OF IMMUNOLOGY (2006)

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Article Biochemistry & Molecular Biology

Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity

M De Martinis et al.

FEBS LETTERS (2005)

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CD27+ (memory) B cell decrease and apoptosis-resistant CD27- (naive) B cell increase in aged humans:: implications for age-related peripheral B cell developmental disturbances

Y Chong et al.

INTERNATIONAL IMMUNOLOGY (2005)

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Expression of the chemokine receptor CCR2 on immature B cells negatively regulates their cytoskeletal rearrangement and migration

L Flaishon et al.

BLOOD (2004)

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Article Hematology

Activated human NK and CD8+ T cells express both TNF-related apoptosis-inducing ligand (TRAIL) and TRAIL receptors but are resistant to TRAIL-mediated cytotoxicity

P Mirandola et al.

BLOOD (2004)

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Review Immunology

Plasma-cell homing

EJ Kunkel et al.

NATURE REVIEWS IMMUNOLOGY (2003)

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Article Oncology

Chemokine receptor CCR2 is expressed by human multiple myeloma cells and mediates migration to bone marrow stromal cell-produced monocyte chemotactic proteins MCP-1,-2 and-3

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