期刊
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.701950
关键词
epidermal lamellar body; lysosome-related organelle; Golgi; lysosome; epidermis
资金
- Science and Engineering Research Board [CRG/2019/000281]
- Department of Biotechnology [BT/PR32489/BRB/10/1786/2019]
- DBT-NBACD [BT/HRD-NBA-NWB/38/2019-20]
- IISc-DBT Partnership Program
- DBT/Wellcome Trust India Alliance Early Career Fellowship [IA/E/17/1/503685]
Epidermal lamellar bodies (eLBs) are secretory organelles necessary for skin homeostasis, belonging to lysosome-related organelles (LROs) with a complex formation process related to other organelles. Disruption of the multistep biogenesis processes often occurs in skin disorders.
Epidermal lamellar bodies (eLBs) are secretory organelles that carry a wide variety of secretory cargo required for skin homeostasis. eLBs belong to the class of lysosomerelated organelles (LROs), which are cell-type-specific organelles that perform diverse functions. The formation of eLBs is thought to be related to that of other LROs, which are formed either through the gradual maturation of Golgi/endosomal precursors or by the conversion of conventional lysosomes. Current evidence suggests that eLB biogenesis presumably initiate from trans-Golgi network and receive cargo from endosomes, and also acquire lysosome characteristics during maturation. These multistep biogenesis processes are frequently disrupted in human skin disorders. However, many gaps remain in our understanding of eLB biogenesis and their relationship to skin diseases. Here, we describe our current understanding on eLB biogenesis with a focus on cargo transport to this LRO and highlight key areas where future research is needed.
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