The Extracellular Matrix in Skin Inflammation and Infection

The extracellular matrix (ECM) is an integral component of all organs and plays a pivotal role in tissue homeostasis and repair. While the ECM was long thought to mostly have passive functions by providing physical stability to tissues, detailed characterization of its physical structure and biochemical properties have uncovered an unprecedented broad spectrum of functions. It is now clear that the ECM not only comprises the essential building block of tissues but also actively supports and maintains the dynamic interplay between tissue compartments as well as embedded resident and recruited inflammatory cells in response to pathologic stimuli. On the other hand, certain pathogens such as bacteria and viruses have evolved strategies that exploit ECM structures for infection of cells and tissues, and mutations in ECM proteins can give rise to a variety of genetic conditions. Here, we review the composition, structure and function of the ECM in cutaneous homeostasis, inflammatory skin diseases such as psoriasis and atopic dermatitis as well as infections as a paradigm for understanding its wider role in human health.

Automated summary

The extracellular matrix (ECM) is a crucial component in tissue homeostasis and repair, with functions beyond providing physical stability. It actively supports the dynamic interactions within tissues and immune cells, while also being exploited by pathogens for infection and linked to genetic conditions. Understanding the composition, structure, and function of ECM is key to comprehending its broader impact on human health.