期刊
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.714330
关键词
LRP6; Wnt; cancer; metabolism; signaling
资金
- National Research Foundation of Korea [NRF-2020R1A2C3013746, 2017M3A9B4062421]
- National Research Foundation of Korea [2017M3A9B4062421] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Wnt signaling pathway, particularly Wnt/beta-catenin signaling, is crucial in development and tissue homeostasis, with dysregulation of components like LRP6 implicated in diseases such as cancer, neurodegeneration, metabolic syndrome, and skeletal disease. The molecular mechanisms by which LRP6 senses Wnt and transduces downstream signaling cascades are still being deciphered, highlighting the complexity and importance of this pathway in various physiological and pathological processes.
Wnt signaling plays crucial roles in development and tissue homeostasis, and its dysregulation leads to various diseases, notably cancer. Wnt/beta-catenin signaling is initiated when the glycoprotein Wnt binds to and forms a ternary complex with the Frizzled and low-density lipoprotein receptor-related protein 5/6 (LRP5/6). Despite being identified as a Wnt co-receptor over 20 years ago, the molecular mechanisms governing how LRP6 senses Wnt and transduces downstream signaling cascades are still being deciphered. Due to its role as one of the main Wnt signaling components, the dysregulation or mutation of LRP6 is implicated in several diseases such as cancer, neurodegeneration, metabolic syndrome and skeletal disease. Herein, we will review how LRP6 is activated by Wnt stimulation and explore the various regulatory mechanisms involved. The participation of LRP6 in other signaling pathways will also be discussed. Finally, the relationship between LRP6 dysregulation and disease will be examined in detail.
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