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p63 establishes epithelial enhancers at critical craniofacial development genes
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DREAM and RB cooperate to induce gene repression and cell-cycle arrest in response to p53 activation
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RB, p130 and p107 differentially repress G1/S and G2/M genes after p53 activation
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Retinoic acid and BMP4 cooperate with p63 to alter chromatin dynamics during surface epithelial commitment
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NATURE GENETICS (2018)
TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma
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CELL REPORTS (2018)
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CELL REPORTS (2018)
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p53 regulates enhancer accessibility and activity in response to DNA damage
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Pioneer transcription factors, chromatin dynamics, and cell fate control
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Integration of TP53, DREAM, MMB-FOXM1 and RB-E2F target gene analyses identifies cell cycle gene regulatory networks
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NUCLEIC ACIDS RESEARCH (2016)
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SCIENTIFIC REPORTS (2016)
Transcription factor p63 bookmarks and regulates dynamic enhancers during epidermal differentiation
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The p53 C Terminus Controls Site-Specific DNA Binding and Promotes Structural Changes within the Central DNA Binding Domain
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MOLECULAR CELL (2015)
TP53 engagement with the genome occurs in distinct local chromatin environments via pioneer factor activity
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A novel ATAC-seq approach reveals lineage-specific reinforcement of the open chromatin landscape via cooperation between BAF and p63
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GENOME BIOLOGY (2015)
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CELL CYCLE (2014)
Pioneer transcription factors in cell reprogramming
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GENES & DEVELOPMENT (2014)
Genome-wide characterization reveals complex interplay between TP53 and TP63 in response to genotoxic stress
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NUCLEIC ACIDS RESEARCH (2014)
Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms
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Redox state of p63 and p73 core domains regulates sequence-specific DNA binding
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)
ΔNp63α represses anti-proliferative genes via H2A.Z deposition
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GENES & DEVELOPMENT (2012)
The accessible chromatin landscape of the human genome
Robert E. Thurman et al.
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Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation
Simon S. McDade et al.
NUCLEIC ACIDS RESEARCH (2012)
Physical Association of HDAC1 and HDAC2 with p63 Mediates Transcriptional Repression and Tumor Maintenance in Squamous Cell Carcinoma
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CANCER RESEARCH (2011)
p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis
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JOURNAL OF CELL BIOLOGY (2011)
p63 maintains keratinocyte proliferative capacity through regulation of Skp2-p130 levels
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JOURNAL OF CELL SCIENCE (2011)
p53 binding to nucleosomes within the p21 promoter in vivo leads to nucleosome loss and transcriptional activation
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DEVELOPMENTAL CELL (2010)
p53 Binding to Nucleosomal DNA Depends on the Rotational Positioning of DNA Response Element
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JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
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COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)
Genome-Wide Profiling of p63 DNA-Binding Sites Identifies an Element that Regulates Gene Expression during Limb Development in the 7q21 SHFM1 Locus
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PLOS GENETICS (2010)
TAp63 induces senescence and suppresses tumorigenesis in vivo
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NATURE CELL BIOLOGY (2009)
p63 and p73 Transcriptionally Regulate Genes Involved in DNA Repair
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PLOS GENETICS (2009)
C-terminal diversity within the p53 family accounts for differences in DNA binding and transcriptional activity
Markus Sauer et al.
NUCLEIC ACIDS RESEARCH (2008)
p63 consensus DNA-binding site: identification, analysis and application into a p63MH algorithm
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ONCOGENE (2007)
p53 and p73 display common and distinct requirements for sequence specific binding to DNA
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NUCLEIC ACIDS RESEARCH (2007)
p63 protects the female germ line during meiotic arrest
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Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells
Annie Yang et al.
MOLECULAR CELL (2006)
p63 regulates proliferation and differentiation of developmentally mature keratinocytes
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GENES & DEVELOPMENT (2006)
Both the basal transcriptional activity of the GADD45A gene and its enhancement after ionizing irradiation are mediated by AP-1 element
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BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION (2006)
Derivation of the consensus DNA-binding sequence for p63 reveals unique requirements that are distinct from p53
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p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors
William M. Keyes et al.
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The unique NH2-terminally deleted (ΔN) residues, the PXXP motif, and the PPXY motif are required for the transcriptional activity of the ΔN variant of p63
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p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress
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CELL DEATH AND DIFFERENTIATION (2006)
TAp63α induces apoptosis by activating signaling via death receptors and mitochondria
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EMBO JOURNAL (2005)
Tumor predisposition in mice mutant for p63 and p73:: Evidence for broader tumor suppressor functions for the p53 family
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CANCER CELL (2005)
ΔNp63α functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes
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ONCOGENE (2003)
The ΔNp63α phosphoprotein binds the p21 and 14-3-3σ promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations
MD Westfall et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
p63 and p73 are required for p53-dependent apoptosis in response to DNA damage
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Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment
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MOLECULAR CELL (2001)
A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain
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MOLECULAR AND CELLULAR BIOLOGY (2001)