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Advances in Chromodomain Helicase DNA-Binding (CHD) Proteins Regulating Stem Cell Differentiation and Human Diseases

期刊

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.710203

关键词

epigenetic; chromodomain helicase DNA-binding protein; chromatin remodeling; histone modification; CHARGE syndrome

资金

  1. National Natural Science Foundation of China (NSFC) [81701009, 82001017]
  2. West China Hospital of Stomatology [RCDWJS2020-23]
  3. China Postdoctoral Science Foundation Grant [2019TQ0218, 2020M683328]

向作者/读者索取更多资源

CHD proteins play a crucial role in stem cell differentiation and human diseases.
Background: Regulation of gene expression is critical for stem cell differentiation, tissue development, and human health maintenance. Recently, epigenetic modifications of histone and chromatin remodeling have been verified as key controllers of gene expression and human diseases. Objective: In this study, we review the role of chromodomain helicase DNA-binding (CHD) proteins in stem cell differentiation, cell fate decision, and several known human developmental disorders and cancers. Conclusion: CHD proteins play a crucial role in stem cell differentiation and human diseases.

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