4.7 Article

Ferroptosis Driver SOCS1 and Suppressor FTH1 Independently Correlate With M1 and M2 Macrophage Infiltration in Head and Neck Squamous Cell Carcinoma

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Physical

Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression

Ori Maller et al.

Summary: Stromal stiffening in malignant tumours is associated with poor treatment outcomes and increased tumour aggression. Identifying factors that regulate stromal stiffening could lead to biomarkers for patient stratification and interventions to improve outcomes. Experimental studies have shown that therapeutic targeting of tumour-associated macrophages and collagen crosslinking enzymes can reduce metastasis and stromal stiffening in aggressive breast cancer subtypes with stiff stroma. Additionally, the expression of lysyl hydroxylase 2 in the stroma has been linked to disease-specific mortality in breast cancer patients, indicating its potential as a stromal biomarker.

NATURE MATERIALS (2021)

Review Cell Biology

Ferroptosis: mechanisms, biology and role in disease

Xuejun Jiang et al.

Summary: Ferroptosis, as a form of regulated cell death driven by iron-dependent phospholipid peroxidation, has seen significant growth in research in recent years. Studies have focused on molecular mechanisms, regulation, and functions of ferroptosis, linking this cell death modality to various pathologies and proposing its roles in normal physiology and potential therapeutic targeting.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Article Cell Biology

CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability

Xingzhe Ma et al.

Summary: Understanding the mechanisms of how T cells become dysfunctional in a tumor microenvironment is crucial for cancer immunotherapy. This study found that CD36 expression in tumor-infiltrating CD8(+) T cells, induced by TME cholesterol, is associated with tumor progression and poor survival, and that genetic ablation of Cd36 in these T cells leads to enhanced tumor eradication. Targeting CD36 or inhibiting ferroptosis could restore T cell function and enhance antitumor efficacy, especially in combination with anti-PD-1 antibodies.

CELL METABOLISM (2021)

Review Oncology

Broadening horizons: the role of ferroptosis in cancer

Xin Chen et al.

Summary: Ferroptosis is an iron-dependent form of regulated cell death driven by excessive lipid peroxidation, and can be induced by various agents to suppress tumor growth while also potentially triggering inflammation-associated immunosuppression. The extent of ferroptosis's impact on tumor biology and its interactions with other signaling pathways are still under investigation.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Article Cell Biology

Comprehensive analysis of ferritin subunits expression and positive correlations with tumor-associated macrophages and T regulatory cells infiltration in most solid tumors

Zhang-Wei Hu et al.

Summary: The study found different expression regulation of FTL and FTH1 in various human cancers, which were associated with patient prognosis and tumor-infiltrating immune cells, suggesting their important role in regulating tumor immunity to solid cancers.

AGING-US (2021)

Article Medicine, Research & Experimental

被撤回的出版物: Bone marrow mesenchymal stem cells-derived exosomal microRNA-19b-3p targets SOCS1 to facilitate progression of esophageal cancer (Retracted article. See vol. 321, 2023)

Yanchao Deng et al.

Summary: BMSC-derived exosomal miR-19b-3p promotes progression of esophageal cancer (EC) by targeting SOCS1. This study provides a novel understanding on the molecular mechanisms of EC.

LIFE SCIENCES (2021)

Article Immunology

Transcriptional and Microenvironmental Landscape of Macrophage Transition in Cancer: A Boolean Analysis

Ugo Avila-Ponce de Leon et al.

Summary: The balance between pro- and anti-inflammatory immune responses is crucial in facing complex diseases like cancer. Macrophages play a key role in this balance in the tumor microenvironment, where cancer cells can evade attack by manipulating macrophages. Despite this, the M1 phenotype still exists and has the ability to eliminate tumor cells. The study used a Boolean modeling approach to understand how the tumor microenvironment influences macrophage behavior and found new hybrid cell populations that were previously undescribed.

FRONTIERS IN IMMUNOLOGY (2021)

Article Medicine, Research & Experimental

SPTBN1 inhibits inflammatory responses and hepatocarcinogenesis via the stabilization of SOCS1 and downregulation of p65 in hepatocellular carcinoma

Ling Lin et al.

Summary: This study found that the loss of SPTBN1 in HCC cells leads to an increase in pro-inflammatory cytokines, further affecting the activation of the NF-kappa B pathway, promoting the formation and development of liver cancer. The loss of SPTBN1 can affect the inflammatory response and tumor development of HCC cells by regulating the SOCS1/p65 pathway.

THERANOSTICS (2021)

Article Oncology

Recurrent HNSCC Harbor an Immunosuppressive Tumor Immune Microenvironment Suggesting Successful Tumor Immune Evasion

Christian Watermann et al.

Summary: Recurrent tumors of head and neck squamous cell carcinoma have an immunosuppressive tumor immune microenvironment, particularly apparent after adjuvant chemoradiotherapy, which may substantially impact therapeutic response and prognosis.

CLINICAL CANCER RESEARCH (2021)

Article Oncology

Cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

Article Cell Biology

Resolvin D1 and D2 inhibit tumour growth and inflammation via modulating macrophage polarization

Kai Shan et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

Article Oncology

LINC00669 insulates the JAK/STAT suppressor SOCS1 to promote nasopharyngeal cancer cell proliferation and invasion

Xiang Qing et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

Review Cell Biology

The Metabolic Underpinnings of Ferroptosis

Jiashuo Zheng et al.

CELL METABOLISM (2020)

Article Medicine, General & Internal

Head and neck squamous cell carcinoma

Daniel E. Johnson et al.

NATURE REVIEWS DISEASE PRIMERS (2020)

Article Mathematical & Computational Biology

FerrDb: a manually curated resource for regulators and markers of ferroptosis and ferroptosis-disease associations

Nan Zhou et al.

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2020)

Article Biochemistry & Molecular Biology

DHA inhibits proliferation and induces ferroptosis of leukemia cells through autophagy dependent degradation of ferritin

Jing Du et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Review Oncology

SOCS1 and its Potential Clinical Role in Tumor

Jie Ying et al.

PATHOLOGY & ONCOLOGY RESEARCH (2019)

Article Multidisciplinary Sciences

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

Weimin Wang et al.

NATURE (2019)

Article Cell Biology

H-Ferritin Affects Cisplatin-Induced Cytotoxicity in Ovarian Cancer Cells through the Modulation of ROS

Alessandro Salatino et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

Review Immunology

Macrophages as regulators of tumour immunity and immunotherapy

David G. DeNardo et al.

NATURE REVIEWS IMMUNOLOGY (2019)

Review Oncology

NRF2 and the Hallmarks of Cancer

Montserrat Rojo de la Vega et al.

CANCER CELL (2018)

Article Multidisciplinary Sciences

Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti-PD-1 treatment

Elisa Peranzoni et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Hematology

Iron and cancer: recent insights

David H. Manz et al.

COOLEY'S ANEMIA (2016)

Article Medicine, General & Internal

Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck

R. L. Ferris et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Hematology

Tumor-Associated Macrophages as a Paradigm of Macrophage Plasticity, Diversity, and Polarization: Lessons and Open Questions

Alberto Mantovani et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2013)

Review Oncology

Iron and cancer: more ore to be mined

Suzy V. Torti et al.

NATURE REVIEWS CANCER (2013)

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.