期刊
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.681186
关键词
macrophage; neddylation; cytokine; migration; polarization
资金
- National Natural Science Foundation of China [81625018, 81820108022, 82003297]
- Innovation Program of Shanghai Municipal Education Commission [2019-01-07-00-10-E00056]
- Program of Shanghai Academic/Technology Research Leader [18XD1403800]
- National Thirteenth Five-Year Science and Technology Major Special Project for New Drug and Development [2017ZX09304001]
- Shanghai Municipal Education Commission
- Shanghai Education Development Foundation [19CG49]
The neddylation pathway regulates the function, migration, survival, and polarization of macrophages, highlighting its implications for cancer therapy.
Tumor-associated macrophages (TAMs) promote cancer progression via stimulating angiogenesis, invasion/metastasis, and suppressing anti-cancer immunity. Targeting TAMs is a potential promising cancer therapeutic strategy. Neddylation adds the ubiquitin-like protein NEDD8 to substrates, and thereby regulates diverse biological processes in multiple cell types, including macrophages. By controlling cellular responses, the neddylation pathway regulates the function, migration, survival, and polarization of macrophages. In the present review we summarized how the neddylation pathway modulates Macrophages and its implications for cancer therapy.
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