期刊
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.714370
关键词
mitochondria; reactive oxygen species; drosophila; embryonic stem cells; induced pluripotent stem cells; electron transport chain; hematopoiesis; HMGB1
资金
- Russian Science Foundation [20-14-00242]
- Russian Science Foundation [20-14-00242] Funding Source: Russian Science Foundation
This review explores the physiological roles of reactive oxygen species (ROS) in cellular and developmental processes, and highlights how studies in Drosophila may offer insights into similar processes in humans, potentially leading to novel therapeutic approaches in ROS-associated diseases.
Reactive oxygen species (ROS), superoxide anion and hydrogen peroxide, are generated as byproducts of oxidative phosphorylation in the mitochondria or via cell signaling-induced NADPH oxidases in the cytosol. In the recent two decades, a plethora of studies established that elevated ROS levels generated by oxidative eustress are crucial physiological mediators of many cellular and developmental processes. In this review, we discuss the mechanisms of ROS generation and regulation, current understanding of ROS functions in the maintenance of adult and embryonic stem cells, as well as in the process of cell reprogramming to a pluripotent state. Recently discovered cell-non-autonomous ROS functions mediated by growth factors are crucial for controlling cell differentiation and cellular immune response in Drosophila. Importantly, many physiological functions of ROS discovered in Drosophila may allow for deciphering and understanding analogous processes in human, which could potentially lead to the development of novel therapeutic approaches in ROS-associated diseases treatment.
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