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Obesity and diabetes are major risk factors for epicardial adipose tissue inflammation

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Summary: This study compared the histological and gene expression differences of epicardial adipose tissue (EAT) between patients with and without coronary artery disease (CAD). The CAD group showed larger epicardial adipocytes and a total of 747 differentially expressed genes (DEGs) were identified in CAD EAT, with more pro-inflammatory and immunological genes and pathways involved. Ten hub DEGs were also identified. EAT in CAD exhibits unique gene expression profiles and may play a key role in the pathological process of CAD.

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