期刊
APPLIED MATERIALS TODAY
卷 23, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.apmt.2021.101000
关键词
Cellulose nanocrystal; Microfluidic electrospray; Core-shell particle; Drug delivery; Wound healing
资金
- National Key Research and Development Program of China [2020YFA0908200]
- National Natural Science Foundation of China [52073060, 81870396, 61927805]
- Natural Science Foundation of Jiangsu [BE2018707]
- General Project of Military Logistics Research [CLB19J025]
- Distinguished Scholars Foundation of Jiangsu Province [JCRCB2016006]
- 333 High Level Talents Training Project of Jiangsu Province [BRA2019011]
This study introduced a multicompartment polysaccharide core-shell microparticle system for enhancing wound healing, exhibiting excellent antibacterial properties and angiogenesis effects.
Natural polysaccharides have a demonstrated value in drug encapsulation and delivery. Effort s in this area are focused on improving the performances of these biomaterials. In this study, we present a multicompartment polysaccharide core-shell microparticle to construct a sustainable dual-release system of active molecules for enhancing wound healing. These microparticles were generated utilizing a microfluidic electrospray approach, in which a mixture of cellulose nanocrystals (CNC) and vascular endothelial growth factor (VEGF) were employed as the cores, with doxycycline hydrochloride (DH) mixed alginate as the shells. The resultant multicompartment particles exhibited wonderful antibacterial properties inherited from the alginate shell, and angiogenesis properties from the CNC core after the shell disintegrated. It was demonstrated that these core-shell microparticles performed their outstanding capabilities in inhibiting inflammation, promoting granulation tissue formation, collagen deposition, and angiogenesis, thereby accelerating rodents' wound healing. These findings support the great potential value of CNC/alginate core-shell microparticles based on the synergistic drug delivery strategy for orchestrating wound healing. (c) 2021 Elsevier Ltd. All rights reserved.
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