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Antibiotic treatment for Tuberculosis induces a profound dysbiosis of the microbiome that persists long after therapy is completed
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SCIENTIFIC REPORTS (2017)
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SCIENTIFIC REPORTS (2017)
Off-Target Effects of Drugs that Disrupt Human Mitochondrial DNA Maintenance
Matthew J. Young
FRONTIERS IN MOLECULAR BIOSCIENCES (2017)
AFEAP cloning: a precise and efficient method for large DNA sequence assembly
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BMC BIOTECHNOLOGY (2017)
Discovery and Total Synthesis of Natural Cystobactamid Derivatives with Superior Activity against Gram-Negative Pathogens
Stephan Huettel et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)
In Vitro and In Vivo Efficacy of an LpxC Inhibitor, CHIR-090, Alone or Combined with Colistin against Pseudomonas aeruginosa Biofilm
Jun Hou Tan et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2017)
New approaches to antibiotic discovery
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BIOTECHNOLOGY LETTERS (2017)
Enzymatic Halogenation and Dehalogenation Reactions: Pervasive and Mechanistically Diverse
Vinayak Agarwal et al.
CHEMICAL REVIEWS (2017)
Culture-independent discovery of natural products from soil metagenomes
Micah Katz et al.
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2016)
Rapid Inhibition Profiling in Bacillus subtilis to Identify the Mechanism of Action of New Antimicrobials
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ACS CHEMICAL BIOLOGY (2016)
BDDCS, the Rule of 5 and drugability
Leslie Z. Benet et al.
ADVANCED DRUG DELIVERY REVIEWS (2016)
Rule of five in 2015 and beyond: Target and ligand structural limitations, ligand chemistry structure and drug discovery project decisions
Christopher A. Lipinski
ADVANCED DRUG DELIVERY REVIEWS (2016)
High-Throughput Single-Cell Cultivation on Microfluidic Streak Plates
Cheng-Ying Jiang et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2016)
Animal models in the pharmacokinetic/pharmacodynamic evaluation of antimicrobial agents
Miao Zhao et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2016)
Characterization and prediction of the mechanism of action of antibiotics through NMR metabolomics
Verena Hoerr et al.
BMC MICROBIOLOGY (2016)
Polypharmacology in Drug Discovery: A Review from Systems Pharmacology Perspective
Wenjuan Zhang et al.
CURRENT PHARMACEUTICAL DESIGN (2016)
Innovation in the pharmaceutical industry: New estimates of R&D costs
Joseph A. DiMasi et al.
JOURNAL OF HEALTH ECONOMICS (2016)
Novel Strategies for the Treatment of Pseudomonas aeruginosa Infections
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JOURNAL OF MEDICINAL CHEMISTRY (2016)
Antibiotic reimbursement in a model delinked from sales: a benchmark-based worldwide approach
John H. Rex et al.
LANCET INFECTIOUS DISEASES (2016)
Validation of Early Human Dose Prediction: A Key Metric for Compound Progression in Drug Discovery
Ken M. Page
MOLECULAR PHARMACEUTICS (2016)
Chemical proteomics approaches for identifying the cellular targets of natural products
M. H. Wright et al.
NATURAL PRODUCT REPORTS (2016)
New tools for reconstruction and heterologous expression of natural product biosynthetic gene clusters
Yunzi Luo et al.
NATURAL PRODUCT REPORTS (2016)
Human commensals producing a novel antibiotic impair pathogen colonization
Alexander Zipperer et al.
NATURE (2016)
Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking
Mingxun Wang et al.
NATURE BIOTECHNOLOGY (2016)
Assembly and clustering of natural antibiotics guides target identification
Chad W. Johnston et al.
NATURE CHEMICAL BIOLOGY (2016)
Scaling laws predict global microbial diversity
Kenneth J. Locey et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
How well can in vitro data predict in vivo effects of chemicals? Rodent carcinogenicity as a case study
Louis Anthony (Tony) Cox et al.
REGULATORY TOXICOLOGY AND PHARMACOLOGY (2016)
Mechanisms of bacterial persistence during stress and antibiotic exposure
Alexander Harms et al.
SCIENCE (2016)
Antibiotic-Induced Changes in the Intestinal Microbiota and Disease
Simone Becattini et al.
TRENDS IN MOLECULAR MEDICINE (2016)
Endless resistance. Endless antibiotics?
Jed F. Fisher et al.
MEDCHEMCOMM (2016)
Persister formation in Staphylococcus aureus is associated with ATP depletion
Brian P. Conlon et al.
NATURE MICROBIOLOGY (2016)
Evidence-Based and Quantitative Prioritization of Tool Compounds in Phenotypic Drug Discovery
Yuan Wang et al.
CELL CHEMICAL BIOLOGY (2016)
Construction of a New Class of Tetracycline Lead Structures with Potent Antibacterial Activity through Biosynthetic Engineering
Urska Lesnik et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)
Pharmacodynamic Profiling of a Siderophore-Conjugated Monocarbam in Pseudomonas aeruginosa: Assessing the Risk for Resistance and Attenuated Efficacy
Aryun Kim et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)
Target-Based Identification of Whole-Cell Active Inhibitors of Biotin Biosynthesis in Mycobacterium tuberculosis
Sae Woong Park et al.
CHEMISTRY & BIOLOGY (2015)
Target Based Drug Design - A Reality in Virtual Sphere
Saroj Verma et al.
CURRENT MEDICINAL CHEMISTRY (2015)
The Joint European Compound Library: boosting precompetitive research
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DRUG DISCOVERY TODAY (2015)
Benefit of Retraining pKa Models Studied Using Internally Measured Data
Peter Gedeck et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2015)
Insights into Structure-Activity Relationships of Bacterial RNA Polymerase Inhibiting Corallopyronin Derivatives
Till F. Schaeberle et al.
JOURNAL OF NATURAL PRODUCTS (2015)
Facilitating quality control for spectra assignments of small organic molecules: nmrshiftdb2-a free in-house NMR database with integrated LIMS for academic service laboratories
Stefan Kuhn et al.
MAGNETIC RESONANCE IN CHEMISTRY (2015)
A new antibiotic kills pathogens without detectable resistance
Losee L. Ling et al.
NATURE (2015)
Computational approaches to natural product discovery
Marnix H. Medema et al.
NATURE CHEMICAL BIOLOGY (2015)
The promise and peril of chemical probes
Cheryl H. Arrowsmith et al.
NATURE CHEMICAL BIOLOGY (2015)
Thermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry
Holger Franken et al.
NATURE PROTOCOLS (2015)
Urinary tract infections: epidemiology, mechanisms of infection and treatment options
Ana L. Flores-Mireles et al.
NATURE REVIEWS MICROBIOLOGY (2015)
Socially mediated induction and suppression of antibiosis during bacterial coexistence
Monica I. Abrudan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Targeting DnaN for tuberculosis therapy using novel griselimycins
Angela Kling et al.
SCIENCE (2015)
Deoxynybomycins inhibit mutant DNA gyrase and rescue mice infected with fluoroquinolone-resistant bacteria
Elizabeth I. Parkinson et al.
NATURE COMMUNICATIONS (2015)
Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research
Norman Moullan et al.
CELL REPORTS (2015)
Machine-Learning Techniques Applied to Antibacterial Drug Discovery
Jacob D. Durrant et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2015)
Genomic tools to profile antibiotic mode of action
Silvia T. Cardona et al.
CRITICAL REVIEWS IN MICROBIOLOGY (2015)
Iron homeostasis in host defence and inflammation
Tomas Ganz et al.
NATURE REVIEWS IMMUNOLOGY (2015)
The Evolving Role of Chemical Synthesis in Antibacterial Drug Discovery
Peter M. Wright et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)
Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates
Bradley Croy Doak et al.
CHEMISTRY & BIOLOGY (2014)
Mining the Metabiome: Identifying Novel Natural Products from Microbial Communities
Aleksandr Milshteyn et al.
CHEMISTRY & BIOLOGY (2014)
Natural Product Synthesis at the Interface of Chemistry and Biology
Jiyong Hong
CHEMISTRY-A EUROPEAN JOURNAL (2014)
Polymeric Nanoparticle Technologies for Oral Drug Delivery
Eric M. Pridgen et al.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2014)
Integrative Approaches for Predicting In Vivo Effects of Chemicals from their Structural Descriptors and the Results of Short-Term Biological Assays
Yen Sia Low et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2014)
Design, synthesis and investigation on the structure-activity relationships of N-substituted 2-aminothiazole derivatives as antitubercular agents
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2014)
Dereplication of microbial extracts and related analytical technologies
Tatsuya Ito et al.
JOURNAL OF ANTIBIOTICS (2014)
Side effects of antibiotics during bacterial infection: Mitochondria, the main target in host cell
Rochika Singh et al.
MITOCHONDRION (2014)
Industrial natural product chemistry for drug discovery and development
Armin Bauer et al.
NATURAL PRODUCT REPORTS (2014)
Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance
Andrew M. King et al.
NATURE (2014)
High-throughput platform for the discovery of elicitors of silent bacterial gene clusters
Mohammad R. Seyedsayamdost
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Gene-targeted microfluidic cultivation validated by isolation of a gut bacterium listed in Human Microbiome Project's Most Wanted taxa
Liang Ma et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Discovery and preclinical development of new antibiotics
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UPSALA JOURNAL OF MEDICAL SCIENCES (2014)
A Glutathione-Dependent Detoxification System Is Required for Formaldehyde Resistance and Optimal Survival of Neisseria meningitidis in Biofilms
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ANTIOXIDANTS & REDOX SIGNALING (2013)
Cloning and Analysis of the Planosporicin Lantibiotic Biosynthetic Gene Cluster of Planomonospora alba
Emma J. Sherwood et al.
JOURNAL OF BACTERIOLOGY (2013)
Principles and Applications of Halogen Bonding in Medicinal Chemistry and Chemical Biology
Rainer Wilcken et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Discovery and Biophysical Characterization of 2-Amino-oxadiazoles as Novel Antagonists of PqsR, an Important Regulator of Pseudomonas aeruginosa Virulence
Michael Zender et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Identification of the chelocardin biosynthetic gene cluster from Amycolatopsis sulphurea: a platform for producing novel tetracycline antibiotics
Tadeja Lukezic et al.
MICROBIOLOGY-SGM (2013)
Bacterial cytological profiling rapidly identifies the cellular pathways targeted by antibacterial molecules
Poochit Nonejuie et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Engineered Streptomyces avermitilis Host for Heterologous Expression of Biosynthetic Gene Cluster for Secondary Metabolites
Mamoru Komatsu et al.
ACS SYNTHETIC BIOLOGY (2013)
Polypharmacology: drug discovery for the future
A. Srinivas Reddy et al.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY (2013)
Distinguishing On-Target versus Off-Target Activity in Early Antibacterial Drug Discovery Using a Macromolecular Synthesis Assay
Mark L. Cunningham et al.
JOURNAL OF BIOMOLECULAR SCREENING (2013)
Applications of Human Pharmacokinetic Prediction in First-in-Human Dose Estimation
Peng Zou et al.
AAPS JOURNAL (2012)
Chemical Inhibitors of the Type Three Secretion System: Disarming Bacterial Pathogens
Miles C. Duncan et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)
Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance
A. -P. Magiorakos et al.
CLINICAL MICROBIOLOGY AND INFECTION (2012)
Understanding efflux in Gram-negative bacteria: opportunities for drug discovery
Herbert P. Schweizer
EXPERT OPINION ON DRUG DISCOVERY (2012)
Corallopyronin A Specifically Targets and Depletes Essential Obligate Wolbachia Endobacteria From Filarial Nematodes In Vivo
Andrea Schiefer et al.
JOURNAL OF INFECTIOUS DISEASES (2012)
Molecular Determinants of AcrB-Mediated Bacterial Efflux Implications for Drug Discovery
John I. Manchester et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Exploiting Adaptive Laboratory Evolution of Streptomyces clavuligerus for Antibiotic Discovery and Overproduction
Pep Charusanti et al.
PLOS ONE (2012)
Novel classes of antibiotics or more of the same?
Anthony R. M. Coates et al.
BRITISH JOURNAL OF PHARMACOLOGY (2011)
Principles of early drug discovery
J. P. Hughes et al.
BRITISH JOURNAL OF PHARMACOLOGY (2011)
Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters
Juan Pablo Gomez-Escribano et al.
MICROBIAL BIOTECHNOLOGY (2011)
Antibacterials from the Sea
Chambers C. Hughes et al.
CHEMISTRY-A EUROPEAN JOURNAL (2010)
How to improve R&D productivity: the pharmaceutical industry's grand challenge
Steven M. Paul et al.
NATURE REVIEWS DRUG DISCOVERY (2010)
A Balancing Act: Efflux/Influx in Mycobacterial Drug Resistance
G. E. Louw et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)
Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success
Frank Lovering et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
CD-Spectroscopy As a Powerful Tool for Investigating the Mode of Action of Unmodified Drugs in Live Cells
Lutz F. Tietze et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Transcription inactivation through local refolding of the RNA polymerase structure
Georgiy A. Belogurov et al.
NATURE (2009)
Evolution of a Fourth Generation Catalyst for the Amination and Thioetherification of Aryl Halides
John F. Hartwig
ACCOUNTS OF CHEMICAL RESEARCH (2008)
Membrane Permeability and Regulation of Drug Influx and Efflux in Enterobacterial Pathogens
Anne Davin-Regli et al.
CURRENT DRUG TARGETS (2008)
Physicochemical properties of antibacterial compounds: Implications for drug discovery
Rosemarie O'Shea et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
A Robust Platform for the Synthesis of New Tetracycline Antibiotics
Cuixiang Sun et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Polymyxin B for the treatment of multidrug-resistant pathogens: a critical review
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JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2007)
NAPROC-13:: a database for the dereplication of natural product mixtures in bioassay-guided protocols
Jose Luis Lopez-Perez et al.
BIOINFORMATICS (2007)
Drugs for bad bugs: confronting the challenges of antibacterial discovery
David J. Payne et al.
NATURE REVIEWS DRUG DISCOVERY (2007)
A review on the use of sodium triacetoxyborohydride in the reductive amination of ketones and aldehydes
Ahmed F. Abdel-Magid et al.
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2006)
Preclinical pharmacokinetics: An approach towards safer and efficacious drugs
SS Singh
CURRENT DRUG METABOLISM (2006)
Strategy of utilizing in vitro and in vivo ADME tools for lead optimization and drug candidate selection
SK Balani et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2005)
RNA polymerase inhibitors with activity against rifampin-resistant mutants of Staphylococcus aureus
A O'Neill et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2000)
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