期刊
NATURE BIOMEDICAL ENGINEERING
卷 5, 期 11, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41551-021-00737-6
关键词
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资金
- Wilhelm Sander-Stiftung [2014.018.1]
- international doctoral program 'i-Target: immunotargeting of cancer' (Elite Network of Bavaria)
- Melanoma Research Alliance [N269626, 409510]
- Marie Sklodowska-Curie Training Network for the Immunotherapy of Cancer (IMMUTRAIN) (Horizon 2020 programme of the European Union)
- Marie Sklodowska-Curie Training Network for Optimizing Adoptive T Cell Therapy of Cancer (Horizon 2020 programme of the European Union) [955575]
- Else Kroner-Fresenius-Stiftung
- German Cancer Aid
- Ernst Jung Stiftung
- Institutional Strategy LMUexcellent of LMU Munich
- Bundesministerium fur Bildung und Forschung
- European Research Council [756017]
- Deutsche Forschungsgemeinschaft (DFG) [INST409/97-1 FUGG, SFB1123/Z1, SFB1321, RE 3723/4-1, 329628492]
- Fritz-Bender Foundation
- Jose Carreras Foundation
- Hector Foundation
- ERA-CVD (AtheroInside)
- AGA-Moti L. & Kamla Rustgi International Travel Award
- German Cancer Aid (Max Eder Program
- Deutsche Krebshilfe) [111273]
- INSERM (HTE: chemotaxis in cancer)
- Volkswagen Foundation (project OntoTime)
- European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme [866411]
- Marie Curie Actions (MSCA) [955575] Funding Source: Marie Curie Actions (MSCA)
Forced expression of C-X-C chemokine receptor type 6 in antigen-specific T cells enhances the recognition and lysis of pancreatic cancer cells, as well as the efficacy of adoptive cell therapy for pancreatic cancer. This strategy leads to improved intratumoral accumulation, sustained anti-tumoral activity, and prolonged animal survival in mouse models with subcutaneous or orthotopic pancreatic tumours. Arming tumour-specific T cells with tumour-specific chemokine receptors may be a promising approach for adoptive cell therapy in solid tumours.
Forced expression of C-X-C chemokine receptor type 6 in antigen-specific T cells enhanced the recognition and lysis of pancreatic cancer cells and the efficacy of adoptive cell therapy for pancreatic cancer. The efficacy of adoptive cell therapy for solid tumours is hampered by the poor accumulation of the transferred T cells in tumour tissue. Here, we show that forced expression of C-X-C chemokine receptor type 6 (whose ligand is highly expressed by human and murine pancreatic cancer cells and tumour-infiltrating immune cells) in antigen-specific T cells enhanced the recognition and lysis of pancreatic cancer cells and the efficacy of adoptive cell therapy for pancreatic cancer. In mice with subcutaneous pancreatic tumours treated with T cells with either a transgenic T-cell receptor or a murine chimeric antigen receptor targeting the tumour-associated antigen epithelial cell adhesion molecule, and in mice with orthotopic pancreatic tumours or patient-derived xenografts treated with T cells expressing a chimeric antigen receptor targeting mesothelin, the T cells exhibited enhanced intratumoral accumulation, exerted sustained anti-tumoral activity and prolonged animal survival only when co-expressing C-X-C chemokine receptor type 6. Arming tumour-specific T cells with tumour-specific chemokine receptors may represent a promising strategy for the realization of adoptive cell therapy for solid tumours.
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