Water extract of pomegranate ash as waste-originated biorenewable catalyst for the novel synthesis of chiral tert-butanesulfinyl aldimines in water

The renewable materials catalyzed reactions in aqueous media is urgently needed and highly fascinating task in the current state of organic synthesis. Here, we report a novel and sustainable protocol for the biorenewable, waste-originated water extract of pomegranate ash (WEPA) catalyzed condensation reaction of tert-butanesulfinamides and aldehydes in water to produce chiral tert-butanesulfinyl aldimines (tBSAIs) in high yields. The products are separated by filtration and purified by recrystallization; avoids the extraction and column chromatographic separation steps. The reaction was performed with high yields in several consecutive recycles of the catalyst and medium, and further this method is highly effective for the multi-gram scale synthesis of tBSAIs. The application of biorenewable catalyst, added metal/catalyst free conditions, absence of volatile organic solvents and additives, vast substrate feasibility, economical profiles, easy operation, reusability of the catalyst, large scale viability, non-chromatographic purification of products and tremendous future perspective are the sparkling insights of this development.

Automated summary

A novel and sustainable protocol utilizing water extract of pomegranate ash as a catalyst in water has been developed for the synthesis of chiral tBSAIs. This method offers advantages such as high yields, catalyst recyclability, and scalability for large-scale production.