期刊
GERIATRICS & GERONTOLOGY INTERNATIONAL
卷 17, 期 7, 页码 1090-1095出版社
WILEY
DOI: 10.1111/ggi.12832
关键词
autoimmune gastritis; gastric emptying; gastrin; multiple autoimmune syndrome; polyautoimmunity
AimElderly patients with autoimmune gastritis might have different symptoms than those of young patients. The aim of the present study was to compare presented symptoms and laboratory parameters associated with autoimmune gastritis in both old and young age groups. MethodsA total of 355 patients with autoimmune gastritis were stratified into two groups: 65years or older (n=119, mean age 69.475.027years), and under 65years (n=236, mean age 45.7910.51years). These two groups were then evaluated and compared by means of clinical symptoms, concurrent autoimmune diseases, serum gastrin, vitaminB(12) and chromograninA levels, and the presence of enterochromograffin-like cell hyperplasia. ResultsAmong 119 older patients, 35 had dyspeptic symptoms, and 84 patients were referred for vitaminB(12) and/or iron deficiency. In the younger group (n=236), there were more patients who had dyspeptic symptoms (36 vs 200, P<0.001). Serum gastrin (726.68 +/- 266.183 vs 214.36 +/- 104.62pg/mL, P<0.001) and chromograninA (301.26 +/- 172.95 vs 106.59 +/- 67.66ng/mL, P<0.001) levels were significantly higher, and the presence of enterochromograffin-like cell hyperplasia was more frequent (113 vs 31, P<0.001) in older patients than younger patients. Polyautoimmunity (66.3% vs 24.5%) and multiple autoimmune syndrome (17.6% vs 5.5%) were more common in older patients (P<0.001). ConclusionsThere are differences in the clinical characteristics and the laboratory parameters between patients with autoimmune gastritis that are older and younger than 65years-of-age. Elderly patients with autoimmune gastritis were investigated more commonly for vitaminB(12) and/or iron deficiency. Polyautoimmunity and multiple autoimmune syndrome were more common, and serum gastrin and chromograninA levels were significantly higher in older patients. Geriatr Gerontol Int 2017; 17: 1090-1095.
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