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Purinergic signaling: A new front-line determinant of resistance and susceptibility in leishmaniasis

期刊

BIOMEDICAL JOURNAL
卷 45, 期 1, 页码 109-117

出版社

ELSEVIER
DOI: 10.1016/j.bj.2021.06.003

关键词

Purinergic signaling; Leishmaniasis; Innate immune response; Evasion

资金

  1. Fundacao de Amparoa Pesquisa do Estado de Sao Paulo - FAPESP [2018/ 14398-0]
  2. Conselho Nacional de Desenvolvimento Cientifico e Tecnologico do Brasil e CNPq [306839/2019-9, 305857/2020-7]
  3. Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
  4. Fundacao de Amparoa Pesquisa do Estado do Rio de Janeiro - FAPERJ [E-26/202.701/ 2019, E-26/010.002260/2019, E-26/010.002985/2014, E-26/010.101036/2018, E-26/202.774/2018]

向作者/读者索取更多资源

Leishmaniasis is a neglected tropical disease that poses a public health problem in developing countries. The interaction between Leishmania parasites, extracellular nucleotides, and purinergic receptors plays a crucial role in determining disease control or dissemination.
Leishmaniasis is a neglected tropical disease that causes several clinical manifestations. Parasites of the genus Leishmania cause this disease. Spread across five continents, leishmaniasis is a particular public health problem in developing countries. Leishmania infects phagocytic cells such as macrophages, where it induces adenosine triphosphate (ATP) release at the time of infection. ATP activates purinergic receptors in the cell membranes of infected cells and promotes parasite control by inducing leukotriene B4 release and NLRP3 inflammasome activation. Moreover, uridine triphosphate induces ATP release, exacerbating the immune response. However, ATP may also undergo catalysis by ectonucleotidases present in the parasite membrane, generating adenosine, which activates P1 receptors and induces the production of anti-inflammatory molecules such as prostaglandin E2 and IL-10. These mechanisms culminate in Leishmania's survival. Thus, how Leishmania handles extracellular nucleotides and the activation of purinergic receptors determines the control or the dissemination of the disease.

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