Understanding the hematopoietic microenvironment in chronic myeloid leukemia: A concise review

Chronic myeloid leukemia (CML) is a myeloproliferative disease that results from the BCR-ABL gene-induced transformation of a primitive hematopoietic cell. This disease has been extensively studied, and, as a result, a very effective therapy has been developed: the tyrosine kinase inhibitors. Although, there is a significant knowledge about the intrinsic biology of CML cells, alterations in their bone marrow microenvironment are not yet completely understood. In this concise review, we summarized recent findings on the composition and function of the bone marrow microenvironment in CML, and their importance in the progression of the disease and treatment resistance. 0 2021 Elsevier Masson SAS. All rights reserved.

Automated summary

CML is a myeloproliferative disease caused by the transformation of primitive hematopoietic cells induced by the BCR-ABL gene, with effective therapy involving tyrosine kinase inhibitors. While there is significant knowledge about the intrinsic biology of CML cells, further research is needed to understand the alterations in their bone marrow microenvironment.