期刊
PROCESSES
卷 9, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/pr9071208
关键词
piRNA; PIWI; PIWIL; small RNA; non-coding RNA; cancer; cancer stem cell; oncogene; tumor-suppressor gene; non-invasive cancer biomarker
资金
- National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [NRF-2019R1A2C1003329]
- Hallym university research funds [HRF-202012-010]
PIWI proteins and piRNAs play roles in regulating upstream or downstream oncogenes or tumor-suppressor genes in cancer tissues, which may have potential applications in cancer therapeutics and as cancer biomarkers, indicating their important research significance.
P-element-induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are regulatory small non-coding RNAs that participate in transposon inactivation, chromatin regulation, and endogenous gene regulation. Numerous genetic and epigenetic factors regulate cell proliferation and tumor metastasis. PIWI proteins and piRNAs have been revealed to function in regulating upstream or downstream of oncogenes or tumor-suppressor genes in cancer tissues. In the present review, we summarize major recent findings in uncovering the regulation and role of PIWI proteins and piRNAs in tumorigenesis and highlight some of the promising applications of specific piRNAs in cancer therapeutics and as cancer biomarkers.
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