期刊
PHARMACEUTICS
卷 13, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/pharmaceutics13070955
关键词
iodine; potassium iodide; iodine deficiency; beta-cyclodextrin; iodine; beta-CD; thyroid-stimulating activity; methimazole
资金
- Ministry of Innovation of the Republic of Uzbekistan [I-SS-2017-6-7]
The article introduces a new method for the synthesis of iodine/beta-cyclodextrin complex and outlines the development of a new quantitative analysis method. Validation results of the high-performance liquid chromatography method demonstrate the reliability and accuracy of the method. The study found that the thyroid-stimulating activity of the iodine/beta-cyclodextrin complex is comparable to that of the conventional drug potassium iodide.
Iodine, being an intrinsic part of thyroid hormones, is a vital microelement required for normal growth and development, particularly in children. Inadequate daily intake of iodine causes iodine deficiency, which is responsible for several health disorders, such as cretinism and goiters. Therefore, the development of new drugs and/or food supplements for iodine deficiency is crucial. We synthesized an iodine/beta-cyclodextrin complex based on a host-guest model, and in this paper, we outline the development of a new quantitative analysis method. We suggest a robust and reliable high-performance liquid chromatography method to determine the total amount of iodine species in the complex. Moreover, we performed validation of our method. The results of validation presented here show the reliability, accuracy and high precision of the method. Furthermore, for the first time, we show results of in vivo studies for the thyroid-stimulating activity of the iodine/beta-cyclodextrin complex. Our findings indicate that the thyroid-stimulating activity of iodine/beta-cyclodextrin is comparable to that of potassium iodide, which is the main active pharmaceutical substance of conventional drugs for iodine deficiency.
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