期刊
PHARMACEUTICS
卷 13, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/pharmaceutics13081240
关键词
radiation chemistry; biomaterials; poly(acrylic acid); biomedical applications; nanocarriers; nanogels; DMTMM; conjugation; bombesin; DOTA; radioisotopes
资金
- International Atomic Energy Agency [F22064, 18354]
- National Science Centre, Poland [2019/33/B/ST5/02125, 2017/27/N/ST4/02536]
- National Center of Research and Development (Warsaw, Poland) [POWR.03.02.00-00-I029/16]
- European Social Fund
Radiation crosslinking was used to create nanocarriers based on poly(acrylic acid) for targeted delivery of radioactive isotopes. The internally crosslinked hydrophilic macromolecules-nanogels were conjugated with bombesin-derivative-oligopeptide and tetraazacyclododecane-1,4,7,10-tetraacetate for selective radioligand transport. The efficiency of radiolabeling nanocarriers with Lu-177 was chromatographically tested, showing promise for theranostic applications.
Radiation crosslinking was employed to obtain nanocarriers based on poly(acrylic acid)-PAA-for targeted delivery of radioactive isotopes. These nanocarriers are internally crosslinked hydrophilic macromolecules-nanogels-bearing carboxylic groups to facilitate functionalization. PAA nanogels were conjugated with an engineered bombesin-derivative-oligopeptide combined with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate chelating moiety, aimed to provide selective radioligand transport. 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium (DMTMM) toluene-4-sulfonate was used as the coupling agent. After tests on a model amine-p-toluidine-both commercial and home-synthesized DOTA-bombesin were successfully coupled to the nanogels and the obtained products were characterized. The radiolabeling efficiency of nanocarriers with Lu-177, was chromatographically tested. The results provide a proof of concept for the synthesis of radiation-synthesized nanogel-based radioisotope nanocarriers for theranostic applications.
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