期刊
PHARMACEUTICS
卷 13, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/pharmaceutics13101538
关键词
cancer therapy; active targeting; ligand; receptor; liposomes; solid lipid nanoparticles; polymeric nanocarriers; nanobubbles
资金
- Ministry of University and Research-University of Turin Fondi Ricerca Locale (ex-60%)
Active targeting with nanodelivery systems is a valuable approach to enhance therapeutic efficacy, with Italian Pharmaceutical Technology academic groups focusing on the development of actively targeted nanosystems using a multidisciplinary approach. Polymeric nanoparticles and liposomes are highlighted as key tools for improving specific drug delivery to targeted receptors.
Active targeting is a valuable and promising approach with which to enhance the therapeutic efficacy of nanodelivery systems, and the development of tumor-targeted nanoparticles has therefore attracted much research attention. In this field, the research carried out in Italian Pharmaceutical Technology academic groups has been focused on the development of actively targeted nanosystems using a multidisciplinary approach. To highlight these efforts, this review reports a thorough description of the last 10 years of Italian research results on the development of actively targeted nanoparticles to direct drugs towards different receptors that are overexpressed on cancer cells or in the tumor microenvironment. In particular, the review discusses polymeric nanocarriers, liposomes, lipoplexes, niosomes, solid lipid nanoparticles, squalene nanoassemblies and nanobubbles. For each nanocarrier, the main ligands, conjugation strategies and target receptors are described. The literature indicates that polymeric nanoparticles and liposomes stand out as key tools for improving specific drug delivery to the site of action. In addition, solid lipid nanoparticles, squalene nanoparticles and nanobubbles have also been successfully proposed. Taken together, these strategies all offer many platforms for the design of nanocarriers that are suitable for future clinical translation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据