4.7 Article

M1 Macrophage-Derived Exosomes Loaded with Gemcitabine and Deferasirox against Chemoresistant Pancreatic Cancer

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Medicine, Research & Experimental

Inhibiting RRM2 to enhance the anticancer activity of chemotherapy

Yaqiong Zhan et al.

Summary: RRM2, the small subunit of ribonucleotide reductase, is commonly overexpressed in chemo-resistant cancer cells, mediating resistance to many chemotherapeutic drugs. Inhibition of RRM2 could enhance the anticancer activity of chemotherapy.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Chemistry, Multidisciplinary

Co-delivery of Salinomycin and Curcumin for Cancer Stem Cell Treatment by Inhibition of Cell Proliferation, Cell Cycle Arrest, and Epithelial-Mesenchymal Transition

Yongmei Zhao et al.

Summary: A specific multi-target drug delivery nanoparticle system targeting breast cancer stem cells has been developed with a therapeutic efficacy. The system combines curcumin and salinomycin, inducing G(1) cell cycle arrest and limiting epithelial-mesenchymal transition effectively.

FRONTIERS IN CHEMISTRY (2021)

Article Engineering, Biomedical

Metastasis-on-a-chip reveals adipocyte-derived lipids trigger cancer cell migration via HIF-1α activation in cancer cells

Jieun Seo et al.

Summary: This study established a 3D culture system to investigate the interactions between adipocyte derived stem cells and cancer cells, revealing the role of the lipid/HIF-1 alpha axis in promoting tumor metastasis. The findings provide new mechanistic insights into the effects of ADSC-released fatty acids on cancer cells as oncometabolites.

BIOMATERIALS (2021)

Article Engineering, Environmental

Synergistic ferroptosis and macrophage re-polarization using engineering exosome-mimic M1 nanovesicles for cancer metastasis suppression

Ping Li et al.

Summary: Ferroptosis has shown effectiveness in cancer metastasis treatment, but limitations in internal ferric aggregation and catalysis at desired sites hinder further therapeutic applications. Modified M1 macrophages with up-regulated CCR2 expression serve as Fe3O4 nanoparticles carrier, which are extruded into exosome-mimic nanovesicles for preferential delivery. This approach demonstrates promising modification efficiency and large-scale production, with potential for inducing macrophage repolarization and tumor-specific immune response in cancer metastasis management.

CHEMICAL ENGINEERING JOURNAL (2021)

Article Chemistry, Multidisciplinary

Exosome-mediated siRNA delivery to suppress postoperative breast cancer metastasis

Liuwan Zhao et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Article Chemistry, Multidisciplinary

Organic Semiconducting Pro-nanostimulants for Near-Infrared Photoactivatable Cancer Immunotherapy

Jingchao Li et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Review Biochemistry & Molecular Biology

Chemoresistance in Pancreatic Cancer

Siyuan Zeng et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Oncology

An update on treatment options for pancreatic adenocarcinoma

Aurelien Lambert et al.

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2019)

Review Pharmacology & Pharmacy

Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery

Sophia G. Antimisiaris et al.

PHARMACEUTICS (2018)

Article Gastroenterology & Hepatology

Microenvironment in determining chemo-resistance in pancreatic cancer: Neighborhood matters

Patricia Dauer et al.

PANCREATOLOGY (2017)

Review Biochemistry & Molecular Biology

Promising molecular mechanisms responsible for gemcitabine resistance in cancer

Yanfei Jia et al.

GENES & DISEASES (2015)

Review Biochemistry & Molecular Biology

A comprehensive overview of exosomes as drug delivery vehicles - Endogenous nanocarriers for targeted cancer therapy

Kasper Bendix Johnsen et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2014)

Review Pharmacology & Pharmacy

ABC transporters in CSCs membranes as a novel target for treating tumor relapse

Laura Zinzi et al.

FRONTIERS IN PHARMACOLOGY (2014)

Review Gastroenterology & Hepatology

Developments in metastatic pancreatic cancer: Is gemcitabine still the standard?

Jie-Er Ying et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2012)

Review Medicine, General & Internal

Pancreatic Cancer

Manuel Hidalgo

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Biochemistry & Molecular Biology

Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening

Piyush B. Gupta et al.