期刊
EPMA JOURNAL
卷 12, 期 3, 页码 265-305出版社
SPRINGER INT PUBL AG
DOI: 10.1007/s13167-021-00248-z
关键词
Predictive preventive personalised medicine (PPPM; 3PM); Endothelin; ET-1; Endothelin axis; Vasoconstriction; Vasodilation; Vasospasm; Nitric oxide; Stroke; Female and male health; Mental health; Lifestyle; Stress reaction; Sense regulation; Wound healing; Pregnancy; Embryonic development; Pain sensitivity; Drug sensitivity; Treatment target; Suboptimal health; Ageing; Metabolic impairments; Cardiovascular disease; Neurodegeneration; Cancer; COVID-19; Individual outcomes
资金
- Projekt DEAL
- LISPER project [313011V446]
- European Association for Predictive, Preventive and Personalised Medicine
Endothelin-1 (ET-1) plays a crucial role in regulating various processes related to physical and mental well-being, and its disrupted homeostasis may impact the development and progression of diseases.
Endothelin-1 (ET-1) is involved in the regulation of a myriad of processes highly relevant for physical and mental well-being; female and male health; in the modulation of senses, pain, stress reactions and drug sensitivity as well as healing processes, amongst others. Shifted ET-1 homeostasis may influence and predict the development and progression of suboptimal health conditions, metabolic impairments with cascading complications, ageing and related pathologies, cardiovascular diseases, neurodegenerative pathologies, aggressive malignancies, modulating, therefore, individual outcomes of both non-communicable and infectious diseases such as COVID-19. This article provides an in-depth analysis of the involvement of ET-1 and related regulatory pathways in physiological and pathophysiological processes and estimates its capacity as a predictor of ageing and related pathologies, a sensor of lifestyle quality and progression of suboptimal health conditions to diseases for their targeted prevention and as a potent target for cost-effective treatments tailored to the person.
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