4.7 Article

The role of Psl in the failure to eradicate Pseudomonas aeruginosa biofilms in children with cystic fibrosis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Immunology

Failed Eradication Therapy of New-Onset Pseudomonas aeruginosa Infections in Children With Cystic Fibrosis Is Associated With Bacterial Resistance to Neutrophil Functions

Kelly Kweng et al.

Summary: This study found that PA isolates from new-onset CF infections exhibit strain-specific susceptibility to neutrophil antibacterial functions, and PA isolates resistant to neutrophil phagocytosis are independent risk factors for failed tobramycin eradication. Experimental results on neutrophil phagocytosis and intracellular killing showed that isolates from persistent infections were more resistant compared to those from eradicated infections.

JOURNAL OF INFECTIOUS DISEASES (2022)

Article Immunology

The Extracellular Polysaccharide Matrix of Pseudomonas aeruginosa Biofilms Is a Determinant of Polymorphonuclear Leukocyte Responses

Morten Rybtke et al.

Summary: Bacterial biofilms can cause chronic infections by evading the immune system and antibiotics, inducing a damaging hyperinflammatory state. Flagella are not necessary for the response of PMNs to Pseudomonas aeruginosa biofilms, with extracellular matrix polysaccharides playing a significant role. Different exopolysaccharide matrix components in P. aeruginosa biofilms elicit distinct PMN responses, highlighting potential therapeutic strategies for mitigating collateral damage in biofilm-based infections.

INFECTION AND IMMUNITY (2021)

Article Cell Biology

Pseudomonas aeruginosa aggregates in cystic fibrosis sputum produce exopolysaccharides that likely impede current therapies

Laura K. Jennings et al.

Summary: In cystic fibrosis airways, Pseudomonas aeruginosa forms biofilms that are thought to contribute to chronic infection. Exopolysaccharides Pel and Psi are expressed in CF airways and play a role in the aggregation mechanism, potentially impacting therapies by increasing antimicrobial tolerance and protecting extracellular DNA from digestion.

CELL REPORTS (2021)

Article Multidisciplinary Sciences

Quantifying the Effects of Antimicrobials on In vitro Biofilm Architecture using COMSTAT Software

Amanda J. Morris et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2020)

Correction Multidisciplinary Sciences

Anti-Psl Targeting of Pseudomonas aeruginosa Biofilms for Neutrophil-Mediated Disruption (vol 7, 2017)

Valerie A. Ray et al.

SCIENTIFIC REPORTS (2018)

Article Multidisciplinary Sciences

Activity of a novel antimicrobial peptide against Pseudomonas aeruginosa biofilms

Trevor Beaudoin et al.

SCIENTIFIC REPORTS (2018)

Article Multidisciplinary Sciences

Entropically driven aggregation of bacteria by host polymers promotes antibiotic tolerance in Pseudomonas aeruginosa

Patrick R. Secor et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Medicine, Research & Experimental

Bispecific antibody targets multiple Pseudomonas aeruginosa evasion mechanisms in the lung vasculature

Ajitha Thanabalasuriar et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Article Respiratory System

Effectiveness of a stepwise Pseudomonas aeruginosa eradication protocol in children with cystic fibrosis

Ana C. Blanchard et al.

JOURNAL OF CYSTIC FIBROSIS (2017)

Article Biotechnology & Applied Microbiology

Staphylococcus aureus interaction with Pseudomonas aeruginosa biofilm enhances tobramycin resistance

T. Beaudoin et al.

NPJ BIOFILMS AND MICROBIOMES (2017)

Article Multidisciplinary Sciences

Anti-Psl Targeting of Pseudomonas aeruginosa Biofilms for Neutrophil-Mediated Disruption

Valerie A. Ray et al.

SCIENTIFIC REPORTS (2017)

Article Infectious Diseases

Chronic infection phenotypes of Pseudomonas aeruginosa are associated with failure of eradication in children with cystic fibrosis

P. Vidya et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2016)

Article Biotechnology & Applied Microbiology

Is biofilm removal properly assessed? Comparison of different quantification methods in a 96-well plate system

Philipp Stiefel et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2016)

Article Respiratory System

Randomized controlled trial of biofilm antimicrobial susceptibility testing in cystic fibrosis patients

Yvonne C. W. Yau et al.

JOURNAL OF CYSTIC FIBROSIS (2015)

Article Critical Care Medicine

Conditions Associated with the Cystic Fibrosis Defect Promote Chronic Pseudomonas aeruginosa Infection

Benjamin J. Staudinger et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2014)

Article Immunology

Pseudomonas aeruginosa Phenotypes Associated With Eradication Failure in Children With Cystic Fibrosis

Nicole Mayer-Hamblett et al.

CLINICAL INFECTIOUS DISEASES (2014)

Article Respiratory System

Effectiveness of inhaled tobramycin in eradicating Pseudomonas aeruginosa in children with cystic fibrosis

Sanja Stanojevic et al.

JOURNAL OF CYSTIC FIBROSIS (2014)

Review Biochemistry & Molecular Biology

Cystic fibrosis: a mucosal immunodeficiency syndrome

Taylor Sitarik Cohen et al.

NATURE MEDICINE (2012)

Article Physics, Multidisciplinary

Polymer-induced phase separation in suspensions of bacteria

J. Schwarz-Linek et al.

Article Biochemistry & Molecular Biology

Pseudomonas aeruginosa uses a cyclic-di-GMP-regulated adhesin to reinforce the biofilm extracellular matrix

Bradley R. Borlee et al.

MOLECULAR MICROBIOLOGY (2010)

Review Respiratory System

Pseudomonas aeruginosa: Host defence in lung diseases

Bryan J. Williams et al.

RESPIROLOGY (2010)

Article Microbiology

Assembly and Development of the Pseudomonas aeruginosa Biofilm Matrix

Luyan Ma et al.

PLOS PATHOGENS (2009)

Article Microbiology

Pseudomonas aeruginosa PSl is a galactose- and mannose-rich exopolysaccharide

Luyan Ma et al.

JOURNAL OF BACTERIOLOGY (2007)

Article Biophysics

Interactions between chitosans and bacterial suspensions: adsorption and flocculation

SP Strand et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2003)