期刊
NPJ BIOFILMS AND MICROBIOMES
卷 7, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41522-021-00220-9
关键词
-
资金
- ANR PIA Glyco@Alps [ANR-15-IDEX-02]
- Alliance Campus Rhodanien Co-Funds
- Labex Arcane/CBH-EUR-GS [ANR-17-EURE-0003]
- March of Dimes
By establishing a classification system and designing models, this study found that bacteria associated with infection and inflammation in the vaginal microbiome produce a greater repertoire of carbohydrate-binding proteins (CBPs), enabling them to bind a wider array of glycans. Both the number and specificity of predicted bacterial CBPs correlated with pathogenicity.
Bacteria use carbohydrate-binding proteins (CBPs), such as lectins and carbohydrate-binding modules (CBMs), to anchor to specific sugars on host surfaces. CBPs in the gut microbiome are well studied, but their roles in the vagina microbiome and involvement in sexually transmitted infections, cervical cancer and preterm birth are largely unknown. We established a classification system for lectins and designed Hidden Markov Model (HMM) profiles for data mining of bacterial genomes, resulting in identification of >100,000 predicted bacterial lectins available at unilectin.eu/bacteria. Genome screening of 90 isolates from 21 vaginal bacterial species shows that those associated with infection and inflammation produce a larger CBPs repertoire, thus enabling them to potentially bind a wider array of glycans in the vagina. Both the number of predicted bacterial CBPs and their specificities correlated with pathogenicity. This study provides new insights into potential mechanisms of colonisation by commensals and potential pathogens of the reproductive tract that underpin health and disease states.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据