期刊
FRONTIERS IN ONCOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2021.649963
关键词
immunotherapy; head and neck cancer; oropharyngeal squamous cell carcinoma; nasopharyngeal carcinoma; viral-associated cancers; human papillomavirus; Epstein-Barr virus
类别
A subset of head and neck cancers in the oropharynx and nasopharynx associated with human papillomavirus or Epstein-Barr virus pose limited treatment options once patients develop recurrent or metastatic disease. Current studies are focusing on utilizing immunotherapy to overcome resistance to standard chemoradiation therapy and improve treatment response and outcomes in these viral-associated cancers.
A subset of head and neck cancers arising in the oropharynx and the nasopharynx are associated with human papillomavirus or Epstein-Barr virus. Unfortunately, limited treatment options exist once patients develop recurrent or metastatic disease in these cancers. Interest has risen in utilizing novel strategies including combination immune checkpoint inhibitors, vaccines, and adoptive cellular therapy, to improve treatment response and outcomes. Several ongoing studies are investigating the potential to overcome resistance to standard of care chemoradiation therapy with monotherapy or combination immunotherapy strategies in these viral-associated head and neck cancers.
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