期刊
FRONTIERS IN ONCOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2021.668151
关键词
microbiota dysbiosis; molecular subtypes; treatment strategy; prognosis; molecular characteristic; endometrioid ovarian cancer
类别
资金
- National Key Research and Development Program [2018YFC1003900]
- National Natural Science Foundation of China [81872110, 81902632]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB29030000]
- Ministry of Science and Technology of China [2016YFC1303503]
- Fundamental Research Funds for the Central Universities [WK9110000104]
Ovarian cancer, especially endometrioid ovarian cancer, is closely related to endometriosis and Lynch syndrome, with dysbiosis of the female reproductive tract microbiota potentially playing a role in its pathogenesis. Dysregulation of the microenvironment and accumulation of mutations are stimulatory factors in the progression of endometrioid ovarian carcinoma. The study of molecular subtypes of endometrioid ovarian cancer is crucial for predicting prognosis.
Ovarian cancer is one of the most common gynecologic cancers that has the highest mortality rate. Endometrioid ovarian cancer, a distinct subtype of epithelial ovarian cancer, is associated with endometriosis and Lynch syndrome, and is often accompanied by synchronous endometrial carcinoma. In recent years, dysbiosis of the microbiota within the female reproductive tract has been suggested to be involved in the pathogenesis of endometrial cancer and ovarian cancer, with some specific pathogens exhibiting oncogenic having been found to contribute to cancer development. It has been shown that dysregulation of the microenvironment and accumulation of mutations are stimulatory factors in the progression of endometrioid ovarian carcinoma. This would be a potential therapeutic target in the future. Simultaneously, multiple studies have demonstrated the role of four molecular subtypes of endometrioid ovarian cancer, which are of particular importance in the prediction of prognosis. This literature review aims to compile the potential mechanisms of endometrioid ovarian cancer, molecular characteristics, and molecular pathological types that could potentially play a role in the prediction of prognosis, and the novel therapeutic strategies, providing some guidance for the stratified management of ovarian cancer.
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