4.6 Review

PHF6 Mutations in Hematologic Malignancies

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

A transcriptomic continuum of differentiation arrest identifies myeloid interface acute leukemias with poor prognosis

Jonathan Bond et al.

Summary: The classification of acute leukemias based on phenotypic resemblance to normal hematopoietic precursors may be too simplistic, as transcriptional analyses have shown significant overlap in gene expression between different diagnostic categories. Identifying interface acute leukemias (IALs) at the myeloid/T-lymphoid interface could potentially improve treatment allocation and evaluation of therapeutic options, especially in cases originally diagnosed as AML with poor prognostic outcomes.

LEUKEMIA (2021)

Article Multidisciplinary Sciences

Targeted sequencing to identify genetic alterations and prognostic markers in pediatric T-cell acute lymphoblastic leukemia

Ya-Hsuan Chang et al.

Summary: Targeted sequencing of 67 genes in 64 cases of childhood T-ALL revealed a variety of genetic mutations, with high frequencies observed in NOTCH1, FAT1, FAT3, and FBXW7. Mutations in certain genes were associated with better 5-year overall survival rates for patients.

SCIENTIFIC REPORTS (2021)

Article Biochemistry & Molecular Biology

Expression profiling of some Acute Myeloid Leukemia - associated markers to assess their diagnostic/prognostic potential

Nahla O. Mousa et al.

Summary: Investigating the etiological causes of acute myeloid leukemia (AML) at the molecular level has revealed significant elevation in the expression levels of PHF6 and ARC in AML patients, with lesser increases observed in ASXL1 and BAX. These markers may serve as reliable prognostic indicators for AML outcomes.

GENETICS AND MOLECULAR BIOLOGY (2021)

Article Biochemistry & Molecular Biology

PHF6 promotes non-homologous end joining and G2 checkpoint recovery

Daniel O. Warmerdam et al.

EMBO REPORTS (2020)

Article Biotechnology & Applied Microbiology

The evolution of relapse of adult T cell acute lymphoblastic leukemia

Ines Sentis et al.

GENOME BIOLOGY (2020)

Article Cell Biology

PHF6 Expression Levels Impact Human Hematopoietic Stem Cell Differentiation

Siebe Loontiens et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Article Oncology

Genetic variants and clinical significance of pediatric acute lymphoblastic leukemia

Hong-Hong Zhang et al.

ANNALS OF TRANSLATIONAL MEDICINE (2019)

Article Medicine, Research & Experimental

The depletion of PHF6 decreases the drug sensitivity of T-cell acute lymphoblastic leukemia to prednisolone

Jinfeng Xiang et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Article Biochemistry & Molecular Biology

Somatic mutations precede myeloid leukemia years before diagnosis

Pinkal Desai et al.

NATURE MEDICINE (2018)

Article Hematology

C-terminal RUNX1 mutation in familial platelet disorder with predisposition to myeloid malignancies

Katerina Stano Kozubik et al.

INTERNATIONAL JOURNAL OF HEMATOLOGY (2018)

Article Multidisciplinary Sciences

Prediction of acute myeloid leukaemia risk in healthy individuals

Sagi Abelson et al.

NATURE (2018)

Article Cell Biology

Characterization of a Mouse Model of Borjeson-Forssman-Lehmann Syndrome

Cheng Cheng et al.

CELL REPORTS (2018)

Article Cell Biology

PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes

Yadira M. Soto-Feliciano et al.

GENES & DEVELOPMENT (2017)

Article Genetics & Heredity

Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia

Masafumi Seki et al.

NATURE GENETICS (2017)

Letter Hematology

PHF6 mutations in paediatric acute myeloid leukaemia

Jasmijn D. E. de Rooij et al.

BRITISH JOURNAL OF HAEMATOLOGY (2016)

Article Biochemistry & Molecular Biology

The sub-nucleolar localization of PHF6 defines its role in rDNA transcription and early processing events

Matthew Am Todd et al.

EUROPEAN JOURNAL OF HUMAN GENETICS (2016)

Article Medicine, General & Internal

Genomic Classification and Prognosis in Acute Myeloid Leukemia

Elli Papaemmanuil et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Medicine, General & Internal

Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia

T. Yoshizato et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Medical Laboratory Technology

The nucleosome remodeling and deacetylase complex in development and disease

Jeannine Basta et al.

TRANSLATIONAL RESEARCH (2015)

Article Biochemistry & Molecular Biology

Structural and Functional Insights into the Human Borjeson- Forssman- Lehmann Syndrome- associated Protein PHF6*

Zhonghua Liu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Multidisciplinary Sciences

The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes

Robert Huether et al.

NATURE COMMUNICATIONS (2014)

Article Biochemistry & Molecular Biology

PHF6 Regulates Cell Cycle Progression by Suppressing Ribosomal RNA Synthesis

Jiadong Wang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Biochemical Research Methods

PHF6 Interacts with the Nucleosome Remodeling and Deacetylation (NuRD) Complex

Matthew A. M. Todd et al.

JOURNAL OF PROTEOME RESEARCH (2012)

Article Multidisciplinary Sciences

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

Jinghui Zhang et al.

NATURE (2012)

Article Oncology

PHF6 mutations in adult acute myeloid leukemia

P. Van Vlierberghe et al.

LEUKEMIA (2011)

Article Multidisciplinary Sciences

Frequent pathway mutations of splicing machinery in myelodysplasia

Kenichi Yoshida et al.

NATURE (2011)

Article Genetics & Heredity

A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)

Konstantinos J. Mavrakis et al.

NATURE GENETICS (2011)

Article Biochemistry & Molecular Biology

Handpicking epigenetic marks with PHD fingers

Catherine A. Musselman et al.

NUCLEIC ACIDS RESEARCH (2011)

Article Genetics & Heredity

PHF6 mutations in T-cell acute lymphoblastic leukemia

Pieter Van Vlierberghe et al.

NATURE GENETICS (2010)

Article Genetics & Heredity

Mutations in PHF6 are associated with Borjeson-Forssman-Lehmann syndrome

KM Lower et al.

NATURE GENETICS (2002)