期刊
FRONTIERS IN ONCOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2021.719513
关键词
oral squamous cell carcinoma; neutrophil-to-lymphocyte ratio; lymphocyte-to-monocyte ratio; neutrophil-to-white blood cell ratio; lymphocyte-to-white blood cell ratio; overall survival; disease-free survival; metastasis-free survival
类别
资金
- National Natural Science Foundation of China [81371680, 81571800, 81772880]
- Development of Science and Technology of Nanjing [201803036]
- Jiangsu Provincial Medical Talent [ZDRCC2016016]
- Nanjing Medical Science and Technique Development Foundation [QRX17083, ZKX18035]
- [YKK18124]
- [YKK20151]
- [YKK19094]
Dynamic changes in immune-inflammatory cell ratios are important prognostic factors for oral squamous cell carcinoma (OSCC), with high LMR and low NWR associated with better survival outcomes, and high NLR and low LWR associated with poorer outcomes. LMR is an independent prognostic factor for OS and DFS, while LWR is an independent prognostic factor for MFS in OSCC patients.
Background Dynamic changes in circulating immune-inflammatory cells have been regarded as simple and convenient prognostic biomarkers in various cancers. However, studies on the prognostic values of their ratios in oral squamous cell carcinoma (OSCC) remain limited. Materials and Methods A total of 493 OSCC patients were included in the present study. Here, we investigated the prognostic values of the neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), neutrophil-to-white blood cell ratio (NWR), and lymphocyte-to-white blood cell ratio (LWR) in OSCC. The correlations of the NLR, LMR, NWR, and LWR with clinicopathological characteristics were statistically analyzed using the Chi-square test, Kaplan-Meier curves, and univariate and multivariate Cox regression models. Result Kaplan-Meier analyses revealed that OSCC patients with a high LMR and low NWR had prolonged overall survival (OS, P<0.001) and disease-free survival (DFS, PP=0.003, respectively), but there were no significant differences in metastasis-free survival (MFS, P=0.053 and P=0.052, respectively). In contrary, a high NLR and low LWR were associated with poor OS (PP=0.0016, respectively), DFS (P=0.0014 and 0.0012, respectively) and MFS (P=0.021 and 0.008, respectively). Additionally, Cox multivariate analyses showed that the LMR was an independent prognostic factor for both OS (P=0.007) and DFS (P=0.017), while the LWR was an independent prognostic factor for MFS (P=0.009). Conclusion Preoperative NLR, LMR, NWR, and LWR in the peripheral blood are significant prognostic factors for OSCC and might be helpful in predicting OSCC progression.
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