期刊
FRONTIERS IN ONCOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2021.698192
关键词
neurofibromatosis (NF); signaling pathway; targeted therapy; natural compounds; eIF4A inhibitors; rocaglamide; didesmethylrocaglamide; protein translation
类别
资金
- Advocure NF2
- CancerFree KIDS
- Sunbeam Foundation
- NF2 Biosolutions
- Department of Defense [W81XWH-18-1-0547, W81XWH-14-1-0167]
- National Institute of Neurological Disorders and Stroke [R01NS113854]
- National Cancer Institute [P01CA125066, P30CA16058]
Neurofibromatosis syndromes, characterized by multiple nervous system tumors, are mainly treated by surgery but some are refractory to conventional chemotherapy. Recent advances in genetics and animal models have led to a better understanding of NF tumor biology and potential targeted therapies. Natural compounds may serve as effective treatments in the future for patients with tumor predisposition syndromes.
The neurofibromatosis syndromes, including NF1, NF2, and schwannomatosis, are tumor suppressor syndromes characterized by multiple nervous system tumors, particularly Schwann cell neoplasms. NF-related tumors are mainly treated by surgery, and some of them have been treated by but are refractory to conventional chemotherapy. Recent advances in molecular genetics and genomics alongside the development of multiple animal models have provided a better understanding of NF tumor biology and facilitated target identification and therapeutic evaluation. Many targeted therapies have been evaluated in preclinical models and patients with limited success. One major advance is the FDA approval of the MEK inhibitor selumetinib for the treatment of NF1-associated plexiform neurofibroma. Due to their anti-neoplastic, antioxidant, and anti-inflammatory properties, selected natural compounds could be useful as a primary therapy or as an adjuvant therapy prior to or following surgery and/or radiation for patients with tumor predisposition syndromes, as patients often take them as dietary supplements and for health enhancement purposes. Here we review the natural compounds that have been evaluated in NF models. Some have demonstrated potent anti-tumor effects and may become viable treatments in the future.
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