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Exosomes-mediated tumor treatment: One body plays multiple roles

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Summary: Nonsmall cell lung cancer (NSCLC) accounts for 80-85% of lung cancer cases. Conventional treatment forms for NSCLC may have rigid schedules and adverse effects, leading to potential resistance. Nanocarriers offer an alternative to overcome these drawbacks for better patient treatment. Nanocarriers can improve drug delivery and reduce toxicities for improved therapeutic efficacy in NSCLC.

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Exosomes as mediators of immune regulation and immunotherapy in cancer

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FEBS JOURNAL (2021)

Review Medicine, Research & Experimental

Exosomes: A new horizon in modern medicine

Ananya Deb et al.

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Jose Luis Palacios-Ferrer et al.

Summary: Malignant melanoma, the most aggressive form of skin cancer, is characterized by its extraordinary metastasis capacity and chemotherapy resistance, mainly due to melanoma cancer stem cells. Current clinical biomarkers for this neoplasia are lacking, highlighting the urgent need for new biomarkers to enable early diagnosis and effective disease monitoring. Exosomes, a novel source of biomarkers, show significant metabolomic differences in MM CSC-derived exosomes and serum-derived exosomes from patients with MM compared to healthy controls, indicating their potential as clinically useful biomarkers for MM diagnosis.

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Recent advances of sorafenib nanoformulations for cancer therapy: Smart nanosystem and combination therapy

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Article Engineering, Biomedical

Light-activatable liposomes for repetitive on-demand drug release and immunopotentiation in hypoxic tumor therapy

Yuanyuan Yang et al.

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Mechanisms underlying low-clinical responses to PD-1/PD-L1 blocking antibodies in immunotherapy of cancer: a key role of exosomal PD-L1

Zi Yin et al.

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Synergetic delivery of triptolide and Ce6 with light-activatable liposomes for efficient hepatocellular carcinoma therapy

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Sonam Gurung et al.

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Inflammatory tumor microenvironment responsive neutrophil exosomes-based drug delivery system for targeted glioma therapy

Jun Wang et al.

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Jie Wang et al.

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TALANTA (2021)

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Summary: With the advancement of regenerative medicine, exosomes, as nanoscale extracellular vesicles transporting biologically active molecules, play a vital role in tissue repair. Exosomes can replicate the functions of parent cells and serve as nanocarriers to deliver active factors promoting tissue repair.

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Xinxin Yuan et al.

Summary: Exosomes derived from breast cancer cells, particularly SCP28 cells, play a crucial role in promoting osteoclast differentiation and activation, contributing to the accelerated formation of a microenvironment favorable for bone metastasis. Specifically, the exosomal miR-21 from SCP28 cells regulates PDCD4 protein levels to facilitate osteoclastogenesis, indicating its potential as a diagnostic and therapeutic target for breast cancer bone metastasis.

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Zhiting Deng et al.

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CXCL-13 Regulates Resistance to 5-Fluorouracil in Colorectal Cancer

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Exosomes as potential sources of biomarkers in colorectal cancer

Yongwei Xiao et al.

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Engineered exosomes for targeted co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon cancer

Gaofeng Liang et al.

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The Emerging Roles of Exosomes as EMT Regulators in Cancer

Hyunwoo Kim et al.

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Xiaoyin Zhao et al.

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Emerging Prospects of Exosomes for Cancer Treatment: From Conventional Therapy to Immunotherapy

Gi-Hoon Nam et al.

ADVANCED MATERIALS (2020)

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Tumor cells derived-exosomes as angiogenenic agents: possible therapeutic implications

Mahdi Ahmadi et al.

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Exosomes as drug delivery systems: A brief overview and progress update

Suyash M. Patil et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2020)

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Do tumor exosome integrins alone determine organotropic metastasis?

E. S. Grigoryeva et al.

MOLECULAR BIOLOGY REPORTS (2020)

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Efficient encapsulation of biocompatible nanoparticles in exosomes for cancer theranostics

Tanziela Tanziela et al.

NANO TODAY (2020)

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Qi Zhan et al.

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Exosome-derived miR-27a produced by PSC-27 cells contributes to prostate cancer chemoresistance through p53

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Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

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Exosomal transfer of long non-coding RNA SBF2-AS1 enhances chemoresistance to temozolomide in glioblastoma

Zhuoran Zhang et al.

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Exosome-Transmitted lncRNA H19 Inhibits the Growth of Pituitary Adenoma

Yong Zhang et al.

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Tumor-derived exosomal miRNA-320d as a biomarker for metastatic colorectal cancer

Youyong Tang et al.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2019)

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Co-Delivery of Prednisolone and Curcumin in Human Serum Albumin Nanoparticles for Effective Treatment of Rheumatoid Arthritis

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INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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The role of exosomal PD-L1 in tumor progression and immunotherapy

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MOLECULAR CANCER (2019)

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A view on drug resistance in cancer

Neil Vasan et al.

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Ovarian cancer cell-secreted exosomal miR-205 promotes metastasis by inducing angiogenesis

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Wei Sun et al.

ACTA PHARMACOLOGICA SINICA (2018)

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Potential roles of tumor-derived exosomes in angiogenesis

Nils Ludwig et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2018)

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Exosomes in Nasopharyngeal Carcinoma

Yujuan Zhou et al.

JOURNAL OF CANCER (2018)

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Recent advancements in the use of exosomes as drug delivery systems

Edwin J. Bunggulawa et al.

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Cancer-derived exosomes as a delivery platform of CRISPR/Cas9 confer cancer cell tropism-dependent targeting

Seung Min Kim et al.

JOURNAL OF CONTROLLED RELEASE (2017)

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PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

Sydney R. Gordon et al.

NATURE (2017)

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Nanoparticulate Delivery of Cancer Cell Membrane Elicits Multiantigenic Antitumor Immunity

Ashley V. Kroll et al.

ADVANCED MATERIALS (2017)

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Cancer nanomedicine: a review of recent success in drug delivery

Stephanie Tran et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2017)

Editorial Material Biology

Q&A: What are exosomes, exactly?

James R. Edgar

BMC BIOLOGY (2016)

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Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis

Hao Gu et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

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Myung Soo Kim et al.

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Exosomes as a Nanodelivery System: a Key to the Future of Neuromedicine?

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MOLECULAR NEUROBIOLOGY (2016)

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Chronic myeloid leukemia-derived exosomes promote tumor growth through an autocrine mechanism

Stefania Raimondo et al.

CELL COMMUNICATION AND SIGNALING (2015)

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Brian T. Luk et al.

JOURNAL OF CONTROLLED RELEASE (2015)

Article Chemistry, Multidisciplinary

Using exosomes, naturally-equipped nanocarriers, for drug delivery

Elena V. Batrakova et al.

JOURNAL OF CONTROLLED RELEASE (2015)

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Principles of nanoparticle design for overcoming biological barriers to drug delivery

Elvin Blanco et al.

NATURE BIOTECHNOLOGY (2015)

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Exosome Delivered Anticancer Drugs Across the Blood-Brain Barrier for Brain Cancer Therapy in Danio Rerio

Tianzhi Yang et al.

PHARMACEUTICAL RESEARCH (2015)

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David W. Greening et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2015)

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Jian Zhang et al.

GENOMICS PROTEOMICS & BIOINFORMATICS (2015)

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Exosomes as nucleic acid nanocarriers

Jasper G. van den Boorn et al.

ADVANCED DRUG DELIVERY REVIEWS (2013)

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Intercellular Transport of MicroRNAs

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ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2013)

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Proteomic Analysis of Exosomes from Mutant KRAS Colon Cancer Cells Identifies Intercellular Transfer of Mutant KRAS

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MOLECULAR & CELLULAR PROTEOMICS (2013)

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NATURE REVIEWS DRUG DISCOVERY (2013)

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Exosomes: Current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials

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BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2012)

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CELLULAR AND MOLECULAR LIFE SCIENCES (2012)

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ORGANOGENESIS (2011)

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Exosomes: Extracellular organelles important in intercellular communication

Suresh Mathivanan et al.

JOURNAL OF PROTEOMICS (2010)

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Membrane vesicles as conveyors of immune responses

Clotilde Thery et al.

NATURE REVIEWS IMMUNOLOGY (2009)

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Epithelial-mesenchymal transition and the invasive potential of tumors

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TRENDS IN MOLECULAR MEDICINE (2008)

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Do Plant Cells Secrete Exosomes Derived from Multivesicular Bodies?

Qianli An et al.

PLANT SIGNALING & BEHAVIOR (2007)

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CANCER RESEARCH (2006)

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AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2002)