期刊
CELLS
卷 10, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/cells10081957
关键词
Muller glia; reprogramming; retinal regeneration; regeneration potential; stem cells; proliferation; differentiation
类别
资金
- Oxford NIHR Biomedical Research Centre
Muller glia play crucial roles in maintaining retinal homeostasis and have regenerative potential in fish and mammals. While they can adopt stem cell characteristics in mammals, their native regeneration potential is limited. Further studies are needed to explore the potential of Muller glia as a source for cell regeneration therapy in humans.
Muller glia, the major glial cell types in the retina, maintain retinal homeostasis and provide structural support to retinal photoreceptors. They also possess regenerative potential that might be used for retinal repair in response to injury or disease. In teleost fish (such as zebrafish), the Muller glia response to injury involves reprogramming events that result in a population of proliferative neural progenitors that can regenerate the injured retina. Recent studies have revealed several important mechanisms for the regenerative capacity of Muller glia in fish, which may shed more light on the mechanisms of Muller glia reprogramming and regeneration in mammals. Mammalian Muller glia can adopt stem cell characteristics, and in response to special conditions, be persuaded to proliferate and regenerate, although their native regeneration potential is limited. In this review, we consider the work to date revealing the regenerative potential of the mammalian Muller glia and discuss whether they are a potential source for cell regeneration therapy in humans.
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