相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington's disease
Eva L. Morozko et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)
STIM2 Mediates Excessive Store-Operated Calcium Entry in Patient-Specific iPSC-Derived Neurons Modeling a Juvenile Form of Huntington's Disease
Vladimir A. Vigont et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)
The difficulty to model Huntington's disease in vitro using striatal medium spiny neurons differentiated from human induced pluripotent stem cells
Kim Le Cann et al.
SCIENTIFIC REPORTS (2021)
Directly reprogrammed Huntington's disease neural precursor cells generate striatal neurons exhibiting aggregates and impaired neuronal maturation
Ruth Monk et al.
STEM CELLS (2021)
Bioenergetic deficits in Huntington's disease iPSC-derived neural cells and rescue with glycolytic metabolites
Amanda J. Kedaigle et al.
HUMAN MOLECULAR GENETICS (2020)
Progerin-Induced Transcriptional Changes in Huntington's Disease Human Pluripotent Stem Cell-Derived Neurons
Dorit Cohen-Carmon et al.
MOLECULAR NEUROBIOLOGY (2020)
Aberrant Development Corrected in Adult-Onset Huntington's Disease iPSC-Derived Neuronal Cultures via WNT Signaling Modulation
Charlene Smith-Geater et al.
STEM CELL REPORTS (2020)
Generation of New Isogenic Models of Huntington's Disease Using CRISPR-Cas9 Technology
Magdalena Dabrowska et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
The Interaction of Aging and Cellular Stress Contributes to Pathogenesis in Mouse and Human Huntington Disease Neurons
Emily Machiela et al.
FRONTIERS IN AGING NEUROSCIENCE (2020)
Mitochondrial and Redox Modifications in Huntington Disease Induced Pluripotent Stem Cells Rescued by CRISPR/Cas9 CAGs Targeting
Carla Lopes et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)
Generation of human striatal organoids and cortico-striatal assembloids from human pluripotent stem cells
Yuki Miura et al.
NATURE BIOTECHNOLOGY (2020)
A Human Induced Pluripotent Stem Cell-Derived Isogenic Model of Huntington's Disease Based on Neuronal Cells Has Several Relevant Phenotypic Abnormalities
Tuyana Malankhanova et al.
JOURNAL OF PERSONALIZED MEDICINE (2020)
Cell-Type-Specific Gene Expression Profiling in Adult Mouse Brain Reveals Normal and Disease-State Signatures
Nicolas Merienne et al.
CELL REPORTS (2019)
Opportunities and challenges for the use of induced pluripotent stem cells in modelling neurodegenerative disease
Yi-Ying Wu et al.
OPEN BIOLOGY (2019)
Astrocyte-Neuron Interactions in the Striatum: Insights on Identity, Form, and Function
Baljit S. Khakh
TRENDS IN NEUROSCIENCES (2019)
Huntington's Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support
Veronica J. Garcia et al.
FRONTIERS IN NEUROSCIENCE (2019)
Robust Preimplantation Genetic Testing of Huntington Disease by Combined Triplet-Primed PCR Analysis of the HTT CAG Repeat and Multi-Microsatellite Haplotyping
Mingjue Zhao et al.
SCIENTIFIC REPORTS (2019)
Mutant huntingtin reduction in astrocytes slows disease progression in the BACHD conditional Huntington's disease mouse model
Tara E. Wood et al.
HUMAN MOLECULAR GENETICS (2019)
Huntington's disease associated resistance to Mn neurotoxicity is neurodevelopmental stage and neuronal lineage dependent
Piyush Joshi et al.
NEUROTOXICOLOGY (2019)
Identification of Altered Developmental Pathways in Human Juvenile HD iPSC With 71Q and 109Q Using Transcriptome Profiling
Karolina Switonska et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2019)
Characterization of Neurodevelopmental Abnormalities in iPSC-Derived Striatal Cultures from Patients with Huntington's Disease
Pranav P. Mathkar et al.
JOURNAL OF HUNTINGTONS DISEASE (2019)
Huntington Disease as a Neurodevelopmental Disorder and Early Signs of the Disease in Stem Cells
Kalina Wiatr et al.
MOLECULAR NEUROBIOLOGY (2018)
Chromosomal instability during neurogenesis in Huntington's disease
Albert Ruzo et al.
DEVELOPMENT (2018)
Epigenetic alterations mediate iPSC-induced normalization of DNA repair gene expression and TNR stability in Huntington's disease cells
Peter A. Mollica et al.
JOURNAL OF CELL SCIENCE (2018)
Striatal neurons directly converted from Huntington's disease patient fibroblasts recapitulate age-associated disease phenotypes
Matheus B. Victor et al.
NATURE NEUROSCIENCE (2018)
Faulty neuronal determination and cell polarization are reverted by modulating HD early phenotypes
P. Conforti et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients
Seda Koyuncu et al.
NATURE COMMUNICATIONS (2018)
Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile
Yongsung Kim et al.
CELL REPORTS (2018)
Altered Expression of Matrix Metalloproteinases and Their Endogenous Inhibitors in a Human Isogenic Stem Cell Model of Huntington's Disease
Swati Naphade et al.
FRONTIERS IN NEUROSCIENCE (2018)
Representing Diversity in the Dish: Using Patient-Derived in Vitro Models to Recreate the Heterogeneity of Neurological Disease
Layla T. Ghaffari et al.
FRONTIERS IN NEUROSCIENCE (2018)
Patient-Specific iPSC-Based Models of Huntington's Disease as a Tool to Study Store-Operated Calcium Entry Drug Targeting
Vladimir Vigont et al.
FRONTIERS IN PHARMACOLOGY (2018)
hPSC-Derived Striatal Cells Generated Using a Scalable 3D Hydrogel Promote Recovery in a Huntington Disease Mouse Model
Maroof M. Adil et al.
STEM CELL REPORTS (2018)
Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington's disease
Rebecca Aron et al.
NATURE COMMUNICATIONS (2018)
Human Huntington's Disease iPSC-Derived Cortical Neurons Display Altered Transcriptomics, Morphology, and Maturation
Shagun R. Mehta et al.
CELL REPORTS (2018)
Conversion of adult human fibroblasts into neural precursor cells using chemically modified mRNA
Bronwen Connor et al.
HELIYON (2018)
Induced pluripotent stem cell technology: a decade of progress
Yanhong Shi et al.
NATURE REVIEWS DRUG DISCOVERY (2017)
FOXOs modulate proteasome activity in human-induced pluripotent stem cells of Huntington's disease and their derived neural cells
Yanying Liu et al.
HUMAN MOLECULAR GENETICS (2017)
Integral Characterization of Defective BDNF/TrkB Signalling in Neurological and Psychiatric Disorders Leads the Way to New Therapies
Gonzalo S. Tejeda et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)
Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice
Ryan G. Lim et al.
NATURE NEUROSCIENCE (2017)
Adenyl cyclase activator forskolin protects against Huntington's disease-like neurodegenerative disorders
Sidharth Mehan et al.
NEURAL REGENERATION RESEARCH (2017)
Mutant Huntingtin Disrupts the Nuclear Pore Complex
Jonathan C. Grima et al.
NEURON (2017)
PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis
Audrey S. Dickey et al.
SCIENCE TRANSLATIONAL MEDICINE (2017)
Direct Conversion of Human Fibroblasts into Neural Progenitors Using Transcription Factors Enriched in Human ESC-Derived Neural Progenitors
Pei-Shan Hou et al.
STEM CELL REPORTS (2017)
Reversal of Phenotypic Abnormalities by CRISPR/Cas9-Mediated Gene Correction in Huntington Disease Patient-Derived Induced Pluripotent Stem Cells
Xiaohong Xu et al.
STEM CELL REPORTS (2017)
Modulating Neurotrophin Receptor Signaling as a Therapeutic Strategy for Huntington's Disease
Danielle A. Simmons
JOURNAL OF HUNTINGTONS DISEASE (2017)
REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways
Janelle Drouin-Ouellet et al.
EMBO MOLECULAR MEDICINE (2017)
RTP801 Is Involved in Mutant Huntingtin-Induced Cell Death
Nuria Martin-Flores et al.
MOLECULAR NEUROBIOLOGY (2016)
DNA Methylation Leads to DNA Repair Gene Down-Regulation and Trinucleotide Repeat Expansion in Patient-Derived Huntington Disease Cells
Peter A. Mollica et al.
AMERICAN JOURNAL OF PATHOLOGY (2016)
Genome Editing in Human Pluripotent Stem Cells: Approaches, Pitfalls, and Solutions
William T. Hendriks et al.
CELL STEM CELL (2016)
Manifestation of Huntington's disease pathology in human induced pluripotent stem cell-derived neurons
Evgeny D. Nekrasov et al.
MOLECULAR NEURODEGENERATION (2016)
Derivation of Huntington Disease affected Genea090 human embryonic stem cell line
Biljana Dumevska et al.
STEM CELL RESEARCH (2016)
Derivation of Huntington Disease affected Genea017 human embryonic stem cell line
Biljana Dumevska et al.
STEM CELL RESEARCH (2016)
Derivation of Huntington Disease affected Genea046 human embryonic stem cell line
Biljana Dumevska et al.
STEM CELL RESEARCH (2016)
Derivation of Huntington Disease affected Genea091 human embryonic stem cell line
Biljana Dumevska et al.
STEM CELL RESEARCH (2016)
Derivation of Huntington Disease affected Genea018 human embryonic stem cell line
Biljana Dumevska et al.
STEM CELL RESEARCH (2016)
Derivation of Huntington Disease affected Genea089 human embryonic stem cell line
Biljana Dumevska et al.
STEM CELL RESEARCH (2016)
Derivation of Huntington disease affected Genea020 human embryonic stem cell line
Biljana Dumevska et al.
STEM CELL RESEARCH (2016)
Epigenetic Control of Reprogramming and Transdifferentiation by Histone Modifications
Hua Qin et al.
STEM CELL REVIEWS AND REPORTS (2016)
Human glia can both induce and rescue aspects of disease phenotype in Huntington disease
Abdellatif Benraiss et al.
NATURE COMMUNICATIONS (2016)
Effects of Rho Kinase Inhibitors on Grafts of Dopaminergic Cell Precursors in a Rat Model of Parkinson's Disease
Jannette Rodriguez-Pallares et al.
STEM CELLS TRANSLATIONAL MEDICINE (2016)
Epigenetic Control of Reprogramming and Transdifferentiation by Histone Modifications
Hua Qin et al.
STEM CELL REVIEWS AND REPORTS (2016)
Neural Conversion and Patterning of Human Pluripotent Stem Cells: A Developmental Perspective
Alexandra Zirra et al.
STEM CELLS INTERNATIONAL (2016)
Conversion of Human Fibroblasts to Stably Self-Renewing Neural Stem Cells with a Single Zinc-Finger Transcription Factor
Ebrahim Shahbazi et al.
STEM CELL REPORTS (2016)
Genomic Instability Associated with p53 Knockdown in the Generation of Huntington's Disease Human Induced Pluripotent Stem Cells
Andrew M. Tidball et al.
PLOS ONE (2016)
Programming and Reprogramming Cellular Age in the Era of Induced Pluripotency
Lorenz Studer et al.
CELL STEM CELL (2015)
Rapid Conversion of Fibroblasts into Functional Forebrain GABAergic Interneurons by Direct Genetic Reprogramming
Gaia Colasante et al.
CELL STEM CELL (2015)
Direct Conversion of Normal and Alzheimer's Disease Human Fibroblasts into Neuronal Cells by Small Molecules
Wenxiang Hu et al.
CELL STEM CELL (2015)
Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects
Jerome Mertens et al.
CELL STEM CELL (2015)
Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons
Xiang Li et al.
CELL STEM CELL (2015)
Huntington disease iPSCs show early molecular changes in intracellular signaling, the expression of oxidative stress proteins and the p53 pathway
Wojciech J. Szlachcic et al.
DISEASE MODELS & MECHANISMS (2015)
HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity
Virginia B. Mattis et al.
HUMAN MOLECULAR GENETICS (2015)
Elucidating the role of the A2A adenosine receptor in neurodegeneration using neurons derived from Huntington's disease iPSCs
Feng-Lan Chiu et al.
HUMAN MOLECULAR GENETICS (2015)
Making (anti-) sense out of huntingtin levels in Huntington disease
Melvin M. Evers et al.
MOLECULAR NEURODEGENERATION (2015)
In Vitro Differentiation of Human Neural Progenitor Cells Into Striatal GABAergic Neurons
Lin Lin et al.
STEM CELLS TRANSLATIONAL MEDICINE (2015)
A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity
Yuwei Yao et al.
ELIFE (2015)
Genomic Analysis Reveals Disruption of Striatal Neuronal Development and Therapeutic Targets in Human Huntington's Disease Neural Stem Cells
Karen L. Ring et al.
STEM CELL REPORTS (2015)
A novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's disease
Andrew M. Tidball et al.
HUMAN MOLECULAR GENETICS (2015)
Inhibition of Excessive Monoamine Oxidase A/B Activity Protects Against Stress-induced Neuronal Death in Huntington Disease
Jolene Ooi et al.
MOLECULAR NEUROBIOLOGY (2015)
Increased Risk of Genetic and Epigenetic Instability in Human Embryonic Stem Cells Associated with Specific Culture Conditions
Ibon Garitaonandia et al.
PLOS ONE (2015)
Three Huntington's Disease Specific Mutation-Carrying Human Embryonic Stem Cell Lines Have Stable Number of CAG Repeats upon In Vitro Differentiation into Cardiomyocytes
Laureen Jacquet et al.
PLOS ONE (2015)
Inhibition of soluble tumor necrosis factor is therapeutic in Huntington's disease
Han-Yun Hsiao et al.
HUMAN MOLECULAR GENETICS (2014)
Proteomics of Huntington's Disease-Affected Human Embryonic Stem Cells Reveals an Evolving Pathology Involving Mitochondrial Dysfunction and Metabolic Disturbances
Leon R. McQuade et al.
JOURNAL OF PROTEOME RESEARCH (2014)
Cell-autonomous correction of ring chromosomes in human induced pluripotent stem cells
Marina Bershteyn et al.
NATURE (2014)
Impaired TrkB Receptor Signaling Underlies Corticostriatal Dysfunction in Huntington's Disease
Joshua L. Plotkin et al.
NEURON (2014)
Generation of Human Striatal Neurons by MicroRNA-Dependent Direct Conversion of Fibroblasts
Matheus B. Victor et al.
NEURON (2014)
Direct Reprogramming of Huntington's Disease Patient Fibroblasts into Neuron-Like Cells Leads to Abnormal Neurite Outgrowth, Increased Cell Death, and Aggregate Formation
Yanying Liu et al.
PLOS ONE (2014)
Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease
Xiao-Hong Lu et al.
SCIENCE TRANSLATIONAL MEDICINE (2014)
miR-196a Ameliorates Phenotypes of Huntington Disease in Cell, Transgenic Mouse, and Induced Pluripotent Stem Cell Models
Pei-Hsun Cheng et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2013)
Transcriptional and Epigenetic Dynamics during Specification of Human Embryonic Stem Cells
Casey A. Gifford et al.
CELL (2013)
Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons
Orly L. Wapinski et al.
CELL (2013)
Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging
Justine D. Miller et al.
CELL STEM CELL (2013)
A novel human embryonic stem cell-derived Huntington's disease neuronal model exhibits mutant huntingtin (mHTT) aggregates and soluble mHTT-dependent neurodegeneration
Boxun Lu et al.
FASEB JOURNAL (2013)
Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration
Xing Guo et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Midbrain-Derived Neurotrophins Support Survival of Immature Striatal Projection Neurons
Maryna Baydyuk et al.
JOURNAL OF NEUROSCIENCE (2013)
Mutant Huntingtin Alters Retrograde Transport of TrkB Receptors in Striatal Dendrites
Geraldine Liot et al.
JOURNAL OF NEUROSCIENCE (2013)
Mosaic Copy Number Variation in Human Neurons
Michael J. McConnell et al.
SCIENCE (2013)
Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds
Pingping Hou et al.
SCIENCE (2013)
Characterization of forebrain neurons derived from late-onset Huntington's disease human embryonic stem cell lines
Jonathan C. Niclis et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2013)
Imbalance of p75NTR/TrkB protein expression in Huntington's disease: implication for neuroprotective therapies
V. Brito et al.
CELL DEATH & DISEASE (2013)
Mature neurons: equipped for survival
A. J. Kole et al.
CELL DEATH & DISEASE (2013)
Small molecules enable neurogenin 2 to efficiently convert human fibroblasts into cholinergic neurons
Meng-Lu Liu et al.
NATURE COMMUNICATIONS (2013)
Managing juvenile Huntington's disease
Oliver W. J. Quarrell et al.
NEURODEGENERATIVE DISEASE MANAGEMENT (2013)
Quantitative proteomic analysis of induced pluripotent stem cells derived from a human Huntington's disease patient
Jung-Il Chae et al.
BIOCHEMICAL JOURNAL (2012)
Induced Pluripotent Stem Cells from Patients with Huntington's Disease Show CAG-Repeat-Expansion-Associated Phenotypes
CELL STEM CELL (2012)
Genetic Correction of Huntington's Disease Phenotypes in Induced Pluripotent Stem Cells
Mahru C. An et al.
CELL STEM CELL (2012)
Self-formation of layered neural structures in three-dimensional culture of ES cells
Mototsugu Eiraku et al.
CURRENT OPINION IN NEUROBIOLOGY (2012)
Early transcriptional changes linked to naturally occurring Huntingtons disease mutations in neural derivatives of human embryonic stem cells
Maxime Feyeux et al.
HUMAN MOLECULAR GENETICS (2012)
Somatic copy number mosaicism in human skin revealed by induced pluripotent stem cells
Alexej Abyzov et al.
NATURE (2012)
Small molecules enable highly efficient neuronal conversion of human fibroblasts
Julia Ladewig et al.
NATURE METHODS (2012)
The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous Huntington's disease patients demonstrates mutation related enhanced lysosomal activity
Stefano Camnasio et al.
NEUROBIOLOGY OF DISEASE (2012)
Maturation of Spinal Motor Neurons Derived from Human Embryonic Stem Cells
Tomonori Takazawa et al.
PLOS ONE (2012)
Modeling human cortical development in vitro using induced pluripotent stem cells
Jessica Mariani et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Neuronal Properties, In Vivo Effects, and Pathology of a Huntington's Disease Patient-Derived Induced Pluripotent Stem Cells
Iksoo Jeon et al.
STEM CELLS (2012)
Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington's disease patient cells
Tarja A. Juopperi et al.
MOLECULAR BRAIN (2012)
Conversion of Mouse and Human Fibroblasts into Functional Spinal Motor Neurons
Esther Y. Son et al.
CELL STEM CELL (2011)
Huntington's and myotonic dystrophy hESCs: down-regulated trinucleotide repeat instability and mismatch repair machinery expression upon differentiation
Anna Seriola et al.
HUMAN MOLECULAR GENETICS (2011)
Somatic coding mutations in human induced pluripotent stem cells
Athurva Gore et al.
NATURE (2011)
MicroRNA-mediated conversion of human fibroblasts to neurons
Andrew S. Yoo et al.
NATURE (2011)
Karotypic abnormalities in human induced pluripotent stem cells and embryonic stem cells
Seth M. Taapken et al.
NATURE BIOTECHNOLOGY (2011)
Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage
Katherine Amps et al.
NATURE BIOTECHNOLOGY (2011)
Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells
Kitai Kim et al.
NATURE BIOTECHNOLOGY (2011)
Investigating synapse formation and function using human pluripotent stem cell-derived neurons
Ji-Eun Kim et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors
Wenlin Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Derivation of Huntington's Disease-Affected Human Embryonic Stem Cell Lines
Cara K. Bradley et al.
STEM CELLS AND DEVELOPMENT (2011)
Identification and Classification of Chromosomal Aberrations in Human Induced Pluripotent Stem Cells
Yoav Mayshar et al.
CELL STEM CELL (2010)
In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects
Mathilde Faideau et al.
HUMAN MOLECULAR GENETICS (2010)
Epigenetic memory in induced pluripotent stem cells
K. Kim et al.
NATURE (2010)
High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity
Elisa Narva et al.
NATURE BIOTECHNOLOGY (2010)
Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells
Jose M. Polo et al.
NATURE BIOTECHNOLOGY (2010)
Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice
Austen J. Milnerwood et al.
NEURON (2010)
Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease
Chiara Zuccato et al.
PHYSIOLOGICAL REVIEWS (2010)
Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation
Hyunkyung Jeong et al.
CELL (2009)
Human embryonic stem cell models of Huntington disease
J. C. Niclis et al.
REPRODUCTIVE BIOMEDICINE ONLINE (2009)
Magnetic resonance imaging as an approach towards identifying neuropathological biomarkers for Huntington's disease
India Bohanna et al.
BRAIN RESEARCH REVIEWS (2008)
Disease-specific induced pluripotent stem cells
In-Hyun Park et al.
CELL (2008)
Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals
Mototsugu Eiraku et al.
CELL STEM CELL (2008)
Epigenetic regulation of stem cell fate
Victoria V. Lunyak et al.
HUMAN MOLECULAR GENETICS (2008)
Huntingtin Regulates RE1-silencing Transcription Factor/Neuron-restrictive Silencer Factor (REST/NRSF) Nuclear Trafficking Indirectly through a Complex with REST/NRSF-interacting LIM Domain Protein (RILP) and Dynactin p150Glued
Masahito Shimojo
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Enhanced Sensitivity of Striatal Neurons to Axonal Transport Defects Induced by Mutant Huntingtin
Lu-Shiun Her et al.
JOURNAL OF NEUROSCIENCE (2008)
Differential Activities of the Ubiquitin-Proteasome System in Neurons versus Glia May Account for the Preferential Accumulation of Misfolded Proteins in Neurons
Suzanne Tydlacka et al.
JOURNAL OF NEUROSCIENCE (2008)
Systematic assessment of BDNF and its receptor levels in human cortices affected by Huntington's disease
Chiara Zuccato et al.
BRAIN PATHOLOGY (2008)
Glutamate uptake is reduced in prefrontal cortex in Huntington's disease
Bjornar Hassel et al.
NEUROCHEMICAL RESEARCH (2008)
Induction of pluripotent stem cells from adult human fibroblasts by defined factors
Kazutoshi Takahashi et al.
CELL (2007)
Sodium phenylbutyrate in Huntington's disease: A dose-finding study
Penelope Hogarth et al.
MOVEMENT DISORDERS (2007)
Microglial activation in presymptomatic Huntington's disease gene carriers
Yen F. Tai et al.
BRAIN (2007)
Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease
Chiara Zuccato et al.
JOURNAL OF NEUROSCIENCE (2007)
Role of brain-derived neurotrophic factor in Huntington's disease
Chiara Zuccato et al.
PROGRESS IN NEUROBIOLOGY (2007)
N-methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease
Mannie M. Y. Fan et al.
PROGRESS IN NEUROBIOLOGY (2007)
The corticostriatal pathway in Huntington's disease
Carlos Cepeda et al.
PROGRESS IN NEUROBIOLOGY (2007)
Genetic analysis of candidate genes modifying the age-at-onset in Huntington's disease
Silke Metzger et al.
HUMAN GENETICS (2006)
Microglial activation correlates with severity in Huntington disease - A clinical and PET study
N. Pavese et al.
NEUROLOGY (2006)
Early development of aberrant synaptic plasticity in a mouse model of Huntington's disease
AJ Milnerwood et al.
HUMAN MOLECULAR GENETICS (2006)
Pharmacological promotion of inclusion formation: A therapeutic approach for Huntington's and Parkinson's diseases
RA Bodner et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Derivation of human embryonic stem cell lines from embryos obtained after IVF and after PGD for monogenic disorders
I Mateizel et al.
HUMAN REPRODUCTION (2006)
Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain
S Ginés et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2006)
Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity
JY Shin et al.
JOURNAL OF CELL BIOLOGY (2005)
Genomic alterations in cultured human embryonic stem cells
A Maitra et al.
NATURE GENETICS (2005)
Progressive loss of BDNF in a mouse model of Huntington's disease and rescue by BDNF delivery
C Zuccato et al.
PHARMACOLOGICAL RESEARCH (2005)
Human embryonic stem cell lines with genetic disorders
Y Verlinsky et al.
REPRODUCTIVE BIOMEDICINE ONLINE (2005)
Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor
ZC Baquet et al.
JOURNAL OF NEUROSCIENCE (2004)
Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease
JM Canals et al.
JOURNAL OF NEUROSCIENCE (2004)
Cellular toxicity of polyglutamine expansion proteins: Mechanism of transcription factor deactivation
G Schaffar et al.
MOLECULAR CELL (2004)
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
B Ravikumar et al.
NATURE GENETICS (2004)
Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes
C Zuccato et al.
NATURE GENETICS (2003)
Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington's disease knock-in mice
S Gines et al.
HUMAN MOLECULAR GENETICS (2003)
Insoluble TATA-binding protein accumulation in Huntington's disease cortex
WMC van Roon-Mom et al.
MOLECULAR BRAIN RESEARCH (2002)
Regulation of TRKB surface expression by brain-derived neurotrophic factor and truncated TRIM Isoforms
A Haapasalo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy
B Ravikumar et al.
HUMAN MOLECULAR GENETICS (2002)
Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease
C Zuccato et al.
SCIENCE (2001)
Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression
ST Suhr et al.
JOURNAL OF CELL BIOLOGY (2001)
Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy
KB Kegel et al.
JOURNAL OF NEUROSCIENCE (2000)
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription
JS Steffan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
分享论文
