The PKD-Dependent Biogenesis of TGN-to-Plasma Membrane Transport Carriers

Membrane trafficking is essential for processing and transport of proteins and lipids and to establish cell compartmentation and tissue organization. Cells respond to their needs and control the quantity and quality of protein secretion accordingly. In this review, we focus on a particular membrane trafficking route from the trans-Golgi network (TGN) to the cell surface: protein kinase D (PKD)-dependent pathway for constitutive secretion mediated by carriers of the TGN to the cell surface (CARTS). Recent findings highlight the importance of lipid signaling by organelle membrane contact sites (MCSs) in this pathway. Finally, we discuss our current understanding of multiple signaling pathways for membrane trafficking regulation mediated by PKD, G protein-coupled receptors (GPCRs), growth factors, metabolites, and mechanosensors.

Automated summary

Membrane trafficking plays a crucial role in processing and transporting proteins and lipids, as well as in establishing cell compartmentation and tissue organization. The focus of this review is on a specific membrane trafficking route from the trans-Golgi network to the cell surface, highlighting the role of PKD-dependent pathway and membrane contact sites in this process. Additionally, the discussion includes various signaling pathways involved in regulating membrane trafficking, such as those mediated by PKD, GPCRs, growth factors, metabolites, and mechanosensors.