期刊
CELLS
卷 10, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/cells10061439
关键词
endocrine disrupting chemicals; acne vulgaris; hormones; nuclear hormone receptors; androgens; estrogens; phytoestrogens
类别
资金
- Frank H. Netter MD School of Medicine at Quinnipiac University, North Haven, CT
The relationship between endocrine disrupting chemicals (EDCs) and the pathogenesis of acne vulgaris has been explored in this review, highlighting how EDCs influence hormonal pathways that contribute to the development of acne lesions. Certain EDCs, such as bisphenol A and mono-2-ethylhexyl Phthalate, can exacerbate cholesterol synthesis through upregulation of lipogenic genes. On the other hand, some phytoestrogen EDCs have a protective role in counteracting androgen-induced sebocyte maturation.
The relationship between endocrine disrupting chemicals (EDCs) and the pathogenesis of acne vulgaris has yet to be explored in the literature. Acne vulgaris is a chronic inflammatory skin disease of the pilosebaceous unit. The pathogenesis of acne involves several hormonal pathways, including androgens, insulin-like growth factor 1(IGF-1), estrogens, and corticosteroids. EDCs influence these pathways primarily through two mechanisms: altering endogenous hormone levels and interfering with hormone receptor function. This review article describes the mechanistic links between EDCs and the development of acne lesions. Highlighted is the contributory role of androgen receptor ligands, such as bisphenol A (BPA) and mono-2-ethylhexyl Phthalate (MEHP), via upregulation of lipogenic genes and resultant exacerbation of cholesterol synthesis. Additionally discussed is the protective role of phytoestrogen EDCs in counteracting androgen-induced sebocyte maturation through attenuation of PPARy transcriptional activity (i.e., resveratrol) and restoration of estrogen-regulated TGF-B expression in skin cells (i.e., genistein). Examination of the relationship between EDCs and acne vulgaris may inform adjunctive avenues of treatment such as limiting environmental exposures, and increasing low-glycemic, plant-rich foods in the diet. With a better understanding of the cumulative role that EDCs play in acne, clinicians can be better equipped to treat and ultimately improve the lives of their patients.
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