Retinal and Brain Microglia in Multiple Sclerosis and Neurodegeneration

Microglia are the resident immune cells of the central nervous system (CNS), including the retina. Similar to brain microglia, retinal microglia are responsible for retinal surveillance, rapidly responding to changes in the environment by altering morphotype and function. Microglia become activated in inflammatory responses in neurodegenerative diseases, including multiple sclerosis (MS). When activated by stress stimuli, retinal microglia change their morphology and activity, with either beneficial or harmful consequences. In this review, we describe characteristics of CNS microglia, including those in the retina, with a focus on their morphology, activation states and function in health, ageing, MS and other neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, glaucoma and retinitis pigmentosa, to highlight their activity in disease. We also discuss contradictory findings in the literature and the potential ways of reducing inconsistencies in future by using standardised methodology, e.g., automated algorithms, to enable a more comprehensive understanding of this exciting area of research.

Automated summary

Microglia are resident immune cells in the CNS and retina, responsible for surveillance and rapid response to changes in the environment. They become activated in inflammatory responses in neurodegenerative diseases, with potential beneficial or harmful consequences when activated by stress stimuli. The review highlights their characteristics, activation states, and function in various diseases, discussing contradictory findings and potential ways to reduce inconsistencies in future research.