期刊
CELLS
卷 10, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/cells10081876
关键词
mitophagy; neurodegenerative diseases; Parkinson's disease; Alzheimer's disease; Huntington's disease; amyotrophic lateral sclerosis
类别
资金
- National Key R&D Program of China [2017YFA010 4200]
- National Natural Science Foundation of China [91854108, 81773182, 31601121]
Mitochondria play a crucial role in providing energy for neurons, and mitophagy helps maintain mitochondrial health. Dysfunctional mitophagy can lead to neurodegenerative diseases, while recent research focuses on understanding the potential role of mitophagy in these diseases and aging, aiming to identify interventions and treatment strategies.
Mitochondria play an essential role in supplying energy for the health and survival of neurons. Mitophagy is a metabolic process that removes dysfunctional or redundant mitochondria. This process preserves mitochondrial health. However, defective mitophagy triggers the accumulation of damaged mitochondria, causing major neurodegenerative disorders. This review introduces molecular mechanisms and signaling pathways behind mitophagy regulation. Furthermore, we focus on the recent advances in understanding the potential role of mitophagy in the pathogenesis of major neurodegenerative diseases (Parkinson's, Alzheimer's, Huntington's, etc.) and aging. The findings will help identify the potential interventions of mitophagy regulation and treatment strategies of neurodegenerative diseases.
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