期刊
CELLS
卷 10, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/cells10061422
关键词
fission yeasts; Rho GTPases; guanine-nucleotide exchange factor (GEF); GTPase-activating protein (GAP); Cdc42; Rho1; cytoskeleton; polarity; cellular integrity; cytokinesis; sexual differentiation; crosstalk; signaling; phosphorylation
类别
资金
- Ministerio de Ciencia, Innovacion y Universidades, Spain [BFU2017-82423-P]
- Fundacion Seneca de la Region de Murcia [20856/PI/18]
- European Regional Development Fund (ERDF)
- European Union
Rho family GTPases in fission yeasts play crucial roles in essential physiological processes such as cellular morphogenesis, integrity, and differentiation, regulated by multiple factors and responsive to external cues.
The Rho family of GTPases represents highly conserved molecular switches involved in a plethora of physiological processes. Fission yeast Schizosaccharomyces pombe has become a fundamental model organism to study the functions of Rho GTPases over the past few decades. In recent years, another fission yeast species, Schizosaccharomyces japonicus, has come into focus offering insight into evolutionary changes within the genus. Both fission yeasts contain only six Rho-type GTPases that are spatiotemporally controlled by multiple guanine-nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and whose intricate regulation in response to external cues is starting to be uncovered. In the present review, we will outline and discuss the current knowledge and recent advances on how the fission yeasts Rho family GTPases regulate essential physiological processes such as morphogenesis and polarity, cellular integrity, cytokinesis and cellular differentiation.
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