期刊
CELLS
卷 10, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/cells10081991
关键词
Charles Bonnet syndrome; EEG; visual hallucination; resting state
类别
资金
- BIAL Foundation
- Belgian National Funds for Scientific Research (FRS-FNRS)
- University and University Hospital of Liege
- fund Leon Fredericq
- Fund Generet
- Mind Care International Foundation
- King Baudouin Foundation
- DOCMA project [EU-H2020-MSCA-RISE-778234]
- AstraZeneca Foundation
- European Union [945539]
- European Space Agency (ESA)
- Belgian Federal Science Policy Office (BELSPO)
- Center-TBI project [FP7-HEALTH-602150]
- Public Utility Foundation Universite Europeenne du Travail
- Fondazione Europea di Ricerca Biomedica
- Mind Science Foundation
- European Commission
This study revealed specific changes in electrical brain activity in CBS patients during visual hallucinations, including alterations in power and connectivity between different brain areas, changes in network properties, and increased signal complexity. These findings suggest that the emergence of hallucinations in CBS may be related to disruptions in the visual cortex and core cortical regions involved in attention and default mode networks.
Charles Bonnet syndrome (CBS) is a rare clinical condition characterized by complex visual hallucinations in people with loss of vision. So far, the neurobiological mechanisms underlying the hallucinations remain elusive. This case-report study aims at investigating electrical activity changes in a CBS patient during visual hallucinations, as compared to a resting-state period (without hallucinations). Prior to the EEG, the patient underwent neuropsychological, ophthalmologic, and neurological examinations. Spectral and connectivity, graph analyses and signal diversity were applied to high-density EEG data. Visual hallucinations (as compared to resting-state) were characterized by a significant reduction of power in the frontal areas, paralleled by an increase in the midline posterior regions in delta and theta bands and by an increase of alpha power in the occipital and midline posterior regions. We next observed a reduction of theta connectivity in the frontal and right posterior areas, which at a network level was complemented by a disruption of small-worldness (lower local and global efficiency) and by an increase of network modularity. Finally, we found a higher signal complexity especially when considering the frontal areas in the alpha band. The emergence of hallucinations may stem from these changes in the visual cortex and in core cortical regions encompassing both the default mode and the fronto-parietal attentional networks.
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