期刊
CELLS
卷 10, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/cells10082060
关键词
colitis-associated colon cancer (CAC); NF-kappa B; STAT3; azoxymethane (AOM)/dextran sulfate sodium (DSS) model; Western diet; orlistat
类别
资金
- National Research Foundation of Korea (NRF) [NRF-2017R1C1B2008617, NRF-2017M3A9B6061511]
- National Research Foundation of Korea [2017M3A9B6061511] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The study found that Western diet exacerbates the development and progression of colon cancer, inducing inflammation, hyperplasia, and tumorigenicity through the activation of STAT3 and NF-kappa B signaling. Additionally, the anti-obesity agent orlistat can improve survival rates, alleviate symptoms of CAC, and suppress tumor progression by inhibiting inflammation and activating STAT3 and NF-kappa B.
Many researchers have argued that Western diet (WD)-induced obesity accelerates inflammation and that inflammation is a link between obesity and colorectal cancer (CRC). This study investigated the effect of WDs on the development and progression of colitis-associated colon cancer (CAC) and the efficacy of the anti-obesity agent orlistat on WD-driven CAC in mice. The results revealed that the WD exacerbated CAC in azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced mice, which showed increased mortality, tumor formation, and aggravation of tumor progression. Furthermore, WD feeding also upregulated inflammation, hyperplasia, and tumorigenicity levels through the activation of STAT3 and NF-kappa B signaling in an AOM/DSS-induced mouse model. In contrast, treatment with orlistat increased the survival rate and alleviated the symptoms of CAC, including a recovery in colon length and tumor production decreases in WD-driven AOM/DSS-induced mice. Additionally, orlistat inhibited the extent of inflammation, hyperplasia, and tumor progression via the inhibition of STAT3 and NF-kappa B activation. Treatment with orlistat also suppressed the beta-catenin, slug, XIAP, Cdk4, cyclin D, and Bcl-2 protein levels in WD-driven AOM/DSS-induced mice. The results of this study indicate that orlistat alleviates colon cancer promotion in WD-driven CAC mice by suppressing inflammation, especially by inhibiting STAT3 and NF-kappa B activation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据