期刊
CELLS
卷 10, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/cells10092447
关键词
circadian clocks; rhythms; organelles; mitochondria; nucleus; endoplasmic reticulum; lysosomes
类别
资金
- Abisch Frenkel Foundation for the Promotion of Life Sciences
- Adelis Foundation
Circadian clocks are present in most light-sensitive organisms, leading to circadian rhythmicity in various biological functions, including intracellular organelles. Although there have been studies on the rhythmicity of organelles, there still exist knowledge gaps, particularly in the understanding of molecular mechanisms and functional significance.
Circadian clocks have evolved in most light-sensitive organisms, from unicellular organisms to mammals. Consequently, a myriad of biological functions exhibits circadian rhythmicity, from behavior to physiology, through tissue and cellular functions to subcellular processes. Circadian rhythms in intracellular organelles are an emerging and exciting research arena. We summarize herein the current literature for rhythmicity in major intracellular organelles in mammals. These include changes in the morphology, content, and functions of different intracellular organelles. While these data highlight the presence of rhythmicity in these organelles, a gap remains in our knowledge regarding the underlying molecular mechanisms and their functional significance. Finally, we discuss the importance and challenges faced by spatio-temporal studies on these organelles and speculate on the presence of oscillators in organelles and their potential mode of communication. As circadian biology has been and continues to be studied throughout temporal and spatial axes, circadian organelles appear to be the next frontier.
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