Cellular Mechanisms of FGF-Stimulated Tissue Repair

Growth factors belonging to the FGF family play important roles in tissue and organ repair after trauma. In this review, I discuss the regulation by FGFs of the aspects of cellular behavior important for reparative processes. In particular, I focus on the FGF-dependent regulation of cell proliferation, cell stemness, de-differentiation, inflammation, angiogenesis, cell senescence, cell death, and the production of proteases. In addition, I review the available literature on the enhancement of FGF expression and secretion in damaged tissues resulting in the increased FGF supply required for tissue repair.

Automated summary

FGF family growth factors are crucial in tissue and organ repair after trauma, regulating various aspects of cellular behavior to facilitate reparative processes. Specifically, FGFs play a key role in controlling cell proliferation, stemness, de-differentiation, inflammation, angiogenesis, senescence, cell death, and protease production. Additionally, enhancing FGF expression and secretion in damaged tissues can increase the supply of FGF required for tissue repair.