期刊
CELLS
卷 10, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/cells10061544
关键词
stem cells; pancreas; 3D bioprinting; diabetes; CRISPR; Cas9; alpha cells; beta cells
类别
资金
- National Centre for Research and Development [STRATEGMED3/305813/2/NCBR/2017]
Type 1 diabetes is a common autoimmune disease that can be treated by culturing human stem cells to differentiate into insulin and glucagon-producing cells for the creation of a bionic pancreas. Solutions for post-transplant immune responses triggered by stem cell-derived pancreatic cells need further exploration.
Type 1 diabetes (T1D) is the third most common autoimmune disease which develops due to genetic and environmental risk factors. Often, intensive insulin therapy is insufficient, and patients require a pancreas or pancreatic islets transplant. However, both solutions are associated with many possible complications, including graft rejection. The best approach seems to be a donor-independent T1D treatment strategy based on human stem cells cultured in vitro and differentiated into insulin and glucagon-producing cells (beta and alpha cells, respectively). Both types of cells can then be incorporated into the bio-ink used for 3D printing of the bionic pancreas, which can be transplanted into T1D patients to restore glucose homeostasis. The aim of this review is to summarize current knowledge about stem cells sources and their transformation into key pancreatic cells. Last, but not least, we comment on possible solutions of post-transplant immune response triggered stem cell-derived pancreatic cells and their potential control mechanisms.
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