期刊
CELLS
卷 10, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/cells10071769
关键词
vascular calcification; ccl2; inflammation; adhesion molecules; VCAM-1; ICAM-1; uremia; thrombomodulin; cardiovascular disease
类别
资金
- Eva and Henry Fraenkel Memorial Foundation
Chronic kidney disease is associated with high cardiovascular mortality and disruption of circadian rhythms in the vasculature, potentially contributing to uremic vasculopathy.
Chronic kidney disease is associated with extremely high cardiovascular mortality. The circadian rhythms (CR) have an impact on vascular function. The disruption of CR causes serious health problems and contributes to the development of cardiovascular diseases. Uremia may affect the master pacemaker of CR in the hypothalamus. A molecular circadian clock is also expressed in peripheral tissues, including the vasculature, where it regulates the different aspects of both vascular physiology and pathophysiology. Here, we address the impact of CKD on the intrinsic circadian clock in the vasculature. The expression of the core circadian clock genes in the aorta is disrupted in CKD. We propose a novel concept of the disruption of the circadian clock system in the vasculature of importance for the pathology of the uremic vasculopathy.
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