4.6 Article

Biparatopic Protein Nanoparticles for the Precision Therapy of CXCR4+ Cancers

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Engineering, Biomedical

Design and engineering of tumor-targeted, dual-acting cytotoxic nanoparticles

Eric Volta-Duran et al.

Summary: The study investigates the potential of conjugating tumor-targeted self-assembling protein nanoparticles with potent microbial toxins and chemically coupled chemotherapeutic drugs, resulting in multifunctional hybrid nanoconjugates with promising applications in oncology. The concept of drug combination proposed in this research could be a feasible strategy for enhancing the effectiveness of multiple drug treatments and overcoming acquired resistance in cancer therapy.

ACTA BIOMATERIALIA (2021)

Article Chemistry, Multidisciplinary

In Vitro Fabrication of Microscale Secretory Granules

Hector Lopez-Laguna et al.

Summary: This research introduces a new fabrication method for microscale protein-only secretory granules that can release drugs in vivo. By utilizing short histidine-tagged proteins and zinc ions, functional and structurally intact granules can be produced, suitable for slow protein drug delivery in diverse clinical scenarios.

ADVANCED FUNCTIONAL MATERIALS (2021)

Article Chemistry, Multidisciplinary

Antineoplastic effect of a diphtheria toxin-based nanoparticle targeting acute myeloid leukemia cells overexpressing CXCR4

Victor Pallares et al.

Summary: This study successfully induced apoptosis in CXCR4+ leukemic cells using a self-assembling protein nanoparticle, and in a mouse model, blocked the dissemination of AML cells without inducing toxicity in healthy tissues.

JOURNAL OF CONTROLLED RELEASE (2021)

Article Chemistry, Multidisciplinary

Artificial Inclusion Bodies for Clinical Development

Julieta M. Sanchez et al.

ADVANCED SCIENCE (2020)

Article Chemistry, Multidisciplinary

Engineering Secretory Amyloids for Remote and Highly Selective Destruction of Metastatic Foci

Maria Virtudes Cespedes et al.

ADVANCED MATERIALS (2020)

Article Chemistry, Multidisciplinary

Nanostructured toxins for the selective destruction of drug-resistant human CXCR4+ colorectal cancer stem cells

Naroa Serna et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Article Chemistry, Physical

Engineering Protein Venoms as Self-Assembling CXCR4-Targeted Cytotoxic Nanoparticles

Naroa Serna et al.

PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION (2020)

Article Engineering, Biomedical

A refined cocktailing of pro-apoptotic nanoparticles boosts anti-tumor activity

Laura Sanchez-Garcia et al.

ACTA BIOMATERIALIA (2020)

Article Chemistry, Multidisciplinary

Engineering Protein Nanoparticles Out from Components of the Human Microbiome

Hector Lopez-Laguna et al.

Article Pharmacology & Pharmacy

Fluorescent Dye Labeling Changes the Biodistribution of Tumor-Targeted Nanoparticles

Patricia Alamo et al.

PHARMACEUTICS (2020)

Article Nanoscience & Nanotechnology

Developing Protein-Antitumoral Drug Nanoconjugates as Bifunctional Antimicrobial Agents

Naroa Serna et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Review Biochemistry & Molecular Biology

Divalent Cations: A Molecular Glue for Protein Materials

Hector Lopez-Laguna et al.

TRENDS IN BIOCHEMICAL SCIENCES (2020)

Article Engineering, Biomedical

Assembly of histidine-rich protein materials controlled through divalent cations

Hector Lopez-Laguna et al.

ACTA BIOMATERIALIA (2019)

Letter Materials Science, Multidisciplinary

Engineering a recombinant chlorotoxin as cell-targeted cytotoxic nanoparticles

Raquel Diaz et al.

SCIENCE CHINA-MATERIALS (2019)

Review Pharmacology & Pharmacy

Advances in Receptor-Mediated, Tumor-Targeted Drug Delivery

Danielle E. Large et al.

ADVANCED THERAPEUTICS (2019)

Article Medicine, General & Internal

2D and 3D cell cultures - a comparison of different types of cancer cell cultures

Marta Kapalczynska et al.

ARCHIVES OF MEDICAL SCIENCE (2018)

Article Chemistry, Multidisciplinary

Self-assembling toxin-based nanoparticles as self-delivered antitumoral drugs

Laura Sanchez-Garcia et al.

JOURNAL OF CONTROLLED RELEASE (2018)

Article Medicine, Research & Experimental

CXCR4 overexpression is correlated with poor prognosis in colorectal cancer

Chao Xu et al.

LIFE SCIENCES (2018)

Review Biotechnology & Applied Microbiology

Protein-Based Therapeutic Killing for Cancer Therapies

Naroa Serna et al.

TRENDS IN BIOTECHNOLOGY (2018)

Article Medicine, Research & Experimental

Selective depletion of metastatic stem cells as therapy for human colorectal cancer

Maria Virtudes Cespedes et al.

EMBO MOLECULAR MEDICINE (2018)

Editorial Material Materials Science, Multidisciplinary

Taking the vehicle out of drug delivery

Jianliang Shen et al.

MATERIALS TODAY (2017)

Review Chemistry, Multidisciplinary

Ligand-Targeted Drug Delivery

Madduri Srinivasarao et al.

CHEMICAL REVIEWS (2017)

Article Chemistry, Multidisciplinary

Peptide-Based Nanostructured Materials with Intrinsic Proapoptotic Activities in CXCR4+ Solid Tumors

Naroa Serna et al.

ADVANCED FUNCTIONAL MATERIALS (2017)

Review Medicine, Research & Experimental

Rational design of fiber forming supramolecular structures

Vivek A. Kumar et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2016)

Review Cell Biology

Proteolytic processing of human serum albumin generates EPI-X4, an endogenous antagonist of CXCR4

Onofrio Zirafi et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2016)

Article Nanoscience & Nanotechnology

Rational engineering of single-chain polypeptides into protein-only, BBB-targeted nanoparticles

Naroa Serna et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2016)

Article Nanoscience & Nanotechnology

Cancer-specific uptake of a liganded protein nanocarrier targeting aggressive CXCR4+ colorectal cancer models

Maria Virtudes Cespedes et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2016)

Review Chemistry, Physical

Supramolecular biomaterials

Matthew J. Webber et al.

NATURE MATERIALS (2016)

Review Pharmacology & Pharmacy

Emerging Strategies for Developing Next-Generation Protein Therapeutics for Cancer Treatment

James R. Kintzing et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2016)

Article Gastroenterology & Hepatology

Colorectal cancer tumour markers and biomarkers: Recent therapeutic advances

Gustaw Lech et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2016)

Review Nanoscience & Nanotechnology

Recent Developments in Active Tumor Targeted Multifunctional Nanoparticles for Combination Chemotherapy in Cancer Treatment and Imaging

Micah D. K. Glasgow et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2015)

Article Materials Science, Multidisciplinary

Formulating tumor-homing peptides as regular nanoparticles enhances receptor-mediated cell penetrability

Zhikun Xu et al.

MATERIALS LETTERS (2015)

Article Cell Biology

Discovery and Characterization of an Endogenous CXCR4 Antagonist

Onofrio Zirafi et al.

CELL REPORTS (2015)

Article Chemistry, Multidisciplinary

In Vivo Architectonic Stability of Fully de Novo Designed Protein-Only Nanoparticles

Maria Virtudes Cespedes et al.

ACS NANO (2014)

Review Chemistry, Multidisciplinary

State-of-the-art in design rules for drug delivery platforms: Lessons learned from FDA-approved nanomedicines

Charlene M. Dawidczyk et al.

JOURNAL OF CONTROLLED RELEASE (2014)

Review Oncology

Tumor-Antigen-Binding Bispecific Antibodies for Cancer Treatment

Ulrich H. Weidle et al.

SEMINARS IN ONCOLOGY (2014)

Review Oncology

A review on CXCR4/CXCL12 axis in oncology: No place to hide

Urszula M. Domanska et al.

EUROPEAN JOURNAL OF CANCER (2013)

Article Nanoscience & Nanotechnology

Intracellular CXCR4+ cell targeting with T22-empowered protein-only nanoparticles

Ugutz Unzueta et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2012)

Review Medicine, Research & Experimental

Nanomedicine(s) under the Microscope

Ruth Duncan et al.

MOLECULAR PHARMACEUTICS (2011)

Article Biotechnology & Applied Microbiology

Protein nanodisk assembling and intracellular trafficking powered by an arginine-rich (R9) peptide

Esther Vazquez et al.

NANOMEDICINE (2010)

Review Pharmacology & Pharmacy

Ligand-based targeted therapy for cancer tissue

Manasi Das et al.

EXPERT OPINION ON DRUG DELIVERY (2009)

Review Biochemistry & Molecular Biology

CXCR4, inhibitors and mechanisms of action

Xiangyang Liang

CHEMICAL BIOLOGY & DRUG DESIGN (2008)

Review Oncology

Therapeutic nanoparticles for drug delivery in cancer

Kwangjae Cho et al.

CLINICAL CANCER RESEARCH (2008)

Review Biochemistry & Molecular Biology

Regulation of CXCR4 signaling

John M. Busillo et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2007)

Article Biochemistry & Molecular Biology

Matrix elasticity directs stem cell lineage specification

Adam J. Engler et al.

Article Biotechnology & Applied Microbiology

Development of potent monoclonal antibody auristatin conjugates for cancer therapy

SO Doronina et al.

NATURE BIOTECHNOLOGY (2003)

Article Biophysics

Molecular dynamics simulations on SDF-1 alpha: Binding with CXCR4 receptor

XQ Huang et al.

BIOPHYSICAL JOURNAL (2003)

Review Pharmacology & Pharmacy

Endogenous carriers and ligands in non-immunogenic site-specific drug delivery

SP Vyas et al.

ADVANCED DRUG DELIVERY REVIEWS (2000)