期刊
CANCERS
卷 13, 期 17, 页码 -出版社
MDPI
DOI: 10.3390/cancers13174435
关键词
exosome; drug delivery system; cancer therapy; exosome engineering
类别
资金
- Mid-career Researcher Program of Korea Institute of Science and Technology (KIST) [NRF-2019R1A2C2010408]
- Brain Pool Program of Korea Institute of Science and Technology (KIST) [NRF-2020H1D3A1A02081401]
- Intramural Research Program of Korea Institute of Science and Technology (KIST)
- National Research Foundation of Korea [2020H1D3A1A02081401] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Exosomes derived from various sources can serve as efficient drug delivery carriers, extending drug half-life and increasing release stability by encapsulating drugs, and possessing natural advantages such as high biocompatibility and low immunogenicity.
Simple Summary Exosomes derived from various sources can deliver therapeutic agents such as small molecule drugs, nucleic acids, and proteins to cancer cells by passive or active targeting. These exosomes can encapsulate drugs inside the exosomes, extending drug half-life and increasing drug release stability. In addition, exosomes are highly biocompatible due to their endogenous origin and can be used as nanocarriers for tissue-specific targeted delivery. This review discusses recent advances in exosome-based drug delivery for cancer therapy. Exosomes are a class of extracellular vesicles, with a size of about 100 nm, secreted by most cells and carrying various bioactive molecules such as nucleic acids, proteins, and lipids, and reflect the biological status of parent cells. Exosomes have natural advantages such as high biocompatibility and low immunogenicity for efficient delivery of therapeutic agents such as chemotherapeutic drugs, nucleic acids, and proteins. In this review, we introduce the latest explorations of exosome-based drug delivery systems for cancer therapy, with particular focus on the targeted delivery of various types of cargoes.
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