相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Reciprocal signaling between mTORC1 and MNK2 controls cell growth and oncogenesis
Jianling Xie et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2021)
Molecular Mechanisms of Endocrine Resistance in Estrogen-Positive Breast Cancer
Esmael Besufikad Belachew et al.
FRONTIERS IN ENDOCRINOLOGY (2021)
DEPTOR is an in vivo tumor suppressor that inhibits prostate tumorigenesis via the inactivation of mTORC1/2 signals
Xiaoyu Chen et al.
ONCOGENE (2020)
Passenger Mutations in More Than 2,500 Cancer Genomes: Overall Molecular Functional Impact and Consequences
Sushant Kumar et al.
CELL (2020)
Androgen modulation of XBP1 is functionally driving part of the AR transcriptional program
Suzan Stelloo et al.
ENDOCRINE-RELATED CANCER (2020)
mTOR at the nexus of nutrition, growth, ageing and disease
Grace Y. Liu et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)
Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis
Richard Y. Ebright et al.
SCIENCE (2020)
Control of translation elongation in health and disease
John R. P. Knight et al.
DISEASE MODELS & MECHANISMS (2020)
Estradiol-Induced Epigenetically Mediated Mechanisms and Regulation of Gene Expression
Tamas Kovacs et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase
Justin T. Ernst et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
The role of the androgen receptor as a driver and mitigator of cellular stress
Dimitrios Doultsinos et al.
JOURNAL OF MOLECULAR ENDOCRINOLOGY (2020)
Mechanisms, regulation and functions of the unfolded protein response
Claudio Hetz et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)
The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling
Boris Y. Shorning et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Identification of Cardiac Glycosides as Novel Inhibitors of eIF4A1-Mediated Translation in Triple-Negative Breast Cancer Cells
Cory M. Howard et al.
CANCERS (2020)
Dual-mTOR Inhibitor Rapalink-1 Reduces Prostate Cancer Patient-Derived Xenograft Growth and Alters Tumor Heterogeneity
Federico La Manna et al.
FRONTIERS IN ONCOLOGY (2020)
Deregulated PTEN/PI3K/AKT/mTOR signaling in prostate cancer: Still a potential druggable target?
Luca Braglia et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2020)
Prostate cancer reactivates developmental epigenomic programs during metastatic progression
Mark M. Pomerantz et al.
NATURE GENETICS (2020)
ReprogrammedmRNAtranslation drives resistance to therapeutic targeting of ribosome biogenesis
Eric P. Kusnadi et al.
EMBO JOURNAL (2020)
DNA-PK, Nuclear mTOR, and the Androgen Pathway in Prostate Cancer
Vincent Giguere
TRENDS IN CANCER (2020)
The integrated stress response: From mechanism to disease
Mauro Costa-Mattioli et al.
SCIENCE (2020)
Response to mTOR and PI3K inhibitors in enzalutamide-resistant luminal androgen receptor triple-negative breast cancer patient-derived xenografts
Florence Coussy et al.
THERANOSTICS (2020)
The Dual PI3K/mTOR Pathway Inhibitor GDC-0084 Achieves Antitumor Activity in PIK3CA-Mutant Breast Cancer Brain Metastases
Franziska M. Ippen et al.
CLINICAL CANCER RESEARCH (2019)
IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling
Xia Sheng et al.
NATURE COMMUNICATIONS (2019)
Eukaryotic initiation factor 4E-binding protein as an oncogene in breast cancer
Alexandria C. Rutkovsky et al.
BMC CANCER (2019)
Randomized phase II trial of neoadjuvant everolimus in patients with high-risk localized prostate cancer
Vadim S. Koshkin et al.
INVESTIGATIONAL NEW DRUGS (2019)
The Organizing Principles of Eukaryotic Ribosome Recruitment
Jerry Pelletier et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 88 (2019)
Phosphoproteome Analysis Reveals Estrogen-ER Pathway as a Modulator of mTOR Activity Via DEPTOR
Rafael Cuesta et al.
MOLECULAR & CELLULAR PROTEOMICS (2019)
The androgen receptor regulates a druggable translational regulon in advanced prostate cancer
Yuzhen Liu et al.
SCIENCE TRANSLATIONAL MEDICINE (2019)
Translational offsetting as a mode of estrogen receptor α-dependent regulation of gene expression
Julie Lorent et al.
EMBO JOURNAL (2019)
Efficacy of PI3K inhibitors in advanced breast cancer
B. Verret et al.
ANNALS OF ONCOLOGY (2019)
Regulation of eIF4F Translation Initiation Complex by the Peptidyl Prolyl Isomerase FKBP7 in Taxane-resistant Prostate Cancer
Marine F. Garrido et al.
CLINICAL CANCER RESEARCH (2019)
Combined Blockade of Activating ERBB2 Mutations and ER Results in Synthetic Lethality of ER+/HER2 Mutant Breast Cancer
Sarah Croessmann et al.
CLINICAL CANCER RESEARCH (2019)
Phase I/II study evaluating the safety and clinical efficacy of temsirolimus and bevacizumab in patients with chemotherapy refractory metastatic castration-resistant prostate cancer
Pedro C. Barata et al.
INVESTIGATIONAL NEW DRUGS (2019)
Estrogen receptor α promotes protein synthesis by fine-tuning the expression of the eukaryotic translation initiation factor 3 subunit f (eIF3f)
Rafael Cuesta et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
Targeting of the Eukaryotic Translation Initiation Factor 4A Against Breast Cancer Stemness
Sangita Sridharan et al.
FRONTIERS IN ONCOLOGY (2019)
Endoplasmic Reticulum Stress Activated by Androgen Enhances Apoptosis of Granulosa Cells via Induction of Death Receptor 5 in PCOS
Jerilee M. K. Azhary et al.
ENDOCRINOLOGY (2019)
FGFR1-Activated Translation of WNT Pathway Components with Structured 5′ UTRs Is Vulnerable to Inhibition of EIF4A-Dependent Translation Initiation
Tuan M. Nguyen et al.
CANCER RESEARCH (2018)
Comprehensive Characterization of Cancer Driver Genes and Mutations
Matthew H. Bailey et al.
CELL (2018)
A phase II study of the dual mTOR inhibitor MLN0128 in patients with metastatic castration resistant prostate cancer
Laura Graham et al.
INVESTIGATIONAL NEW DRUGS (2018)
Randomized Phase II Trial of Fulvestrant Plus Everolimus or Placebo in Postmenopausal Women With Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer Resistant to Aromatase Inhibitor Therapy: Results of PrE0102
Noah Kornblum et al.
JOURNAL OF CLINICAL ONCOLOGY (2018)
Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer
Kevin Shee et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2018)
Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition
Siegfried H. Reich et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Signaling Pathways Involved in the Regulation of mRNA Translation
Philippe P. Roux et al.
MOLECULAR AND CELLULAR BIOLOGY (2018)
SREBF1 Activity Is Regulated by an AR/mTOR Nuclear Axis in Prostate Cancer
Etienne Audet-Walsh et al.
MOLECULAR CANCER RESEARCH (2018)
Roadblocks and resolutions in eukaryotic translation
Anthony P. Schuller et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)
Development of a stress response therapy targeting aggressive prostate cancer
Hao G. Nguyen et al.
SCIENCE TRANSLATIONAL MEDICINE (2018)
Estrogen receptor alpha drives mTORC1 inhibitor-induced feedback activation of PI3K/AKT in ER+ breast cancer
Wei Yang et al.
Oncotarget (2018)
Genome-wide multi-omics profiling of the 8p11-p12 amplicon in breast carcinoma
Toshima Z. Parris et al.
Oncotarget (2018)
Patient-derived Models of Abiraterone- and Enzalutamide-resistant Prostate Cancer Reveal Sensitivity to Ribosome-directed Therapy
Mitchell G. Lawrence et al.
EUROPEAN UROLOGY (2018)
Codon-specific translation reprogramming promotes resistance to targeted therapy
Francesca Rapino et al.
NATURE (2018)
Translation deregulation in human disease
Soroush Tahmasebi et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)
PI3K pathway in prostate cancer: All resistant roads lead to PI3K
Soonbum Park et al.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2018)
mTOR signalling and cellular metabolism are mutual determinants in cancer
Dirk Mossmann et al.
NATURE REVIEWS CANCER (2018)
COSMIC: somatic cancer genetics at high-resolution
Simon A. Forbes et al.
NUCLEIC ACIDS RESEARCH (2017)
Phase Ib dose-finding study of abiraterone acetate plus buparlisib (BKM120) or dactolisib (BEZ235) in patients with castration-resistant prostate cancer
Christophe Massard et al.
EUROPEAN JOURNAL OF CANCER (2017)
Hyperactive mTOR and MNK1 phosphorylation of eIF4E confer tamoxifen resistance and estrogen independence through selective mRNA translation reprogramming
Phillip A. Geter et al.
GENES & DEVELOPMENT (2017)
Nuclear mTOR acts as a transcriptional integrator of the androgen signaling pathway in prostate cancer
Etienne Audet-Walsh et al.
GENES & DEVELOPMENT (2017)
Role of steroid receptor and coregulator mutations in hormone-dependent cancers
Anna C. Groner et al.
JOURNAL OF CLINICAL INVESTIGATION (2017)
FGFR-TACC approaches the first turn in the race for targetable GBM mutations
Cameron Brennan
NEURO-ONCOLOGY (2017)
The androgen receptor is a negative regulator of eIF4E phosphorylation at S209: implications for the use of mTOR inhibitors in advanced prostate cancer
L. S. D'Abronzo et al.
ONCOGENE (2017)
A Phase I Study of Abiraterone Acetate Combined with BEZ235, a Dual PI3K/mTOR Inhibitor, in Metastatic Castration Resistant Prostate Cancer
Xiao X. Wei et al.
ONCOLOGIST (2017)
Crosstalk of the Androgen Receptor with Transcriptional Collaborators: Potential Therapeutic Targets for Castration-Resistant Prostate Cancer
Daisuke Obinata et al.
CANCERS (2017)
Androgen Mediated Regulation of Endoplasmic Reticulum-Associated Degradation and its Effects on Prostate Cancer
Yalcin Erzurumlu et al.
SCIENTIFIC REPORTS (2017)
Universal Patterns of Selection in Cancer and Somatic Tissues
Inigo Martincorena et al.
CELL (2017)
mTORC1 directly phosphorylates and activates ERα upon estrogen stimulation
A. Alayev et al.
ONCOGENE (2016)
The Dual Inhibition of RNA Pol I Transcription and PIM Kinase as a New Therapeutic Approach to Treat Advanced Prostate Cancer
Richard J. Rebello et al.
CLINICAL CANCER RESEARCH (2016)
The integrated stress response
Karolina Pakos-Zebrucka et al.
EMBO REPORTS (2016)
Androgen receptor signaling in castration-resistant prostate cancer: a lesson in persistence
Isabel Coutinho et al.
ENDOCRINE-RELATED CANCER (2016)
Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer
Sylvain Delaunay et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2016)
Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR
Timothy P. Heffron et al.
ACS MEDICINAL CHEMISTRY LETTERS (2016)
New frontiers in translational control of the cancer genome
Morgan L. Truitt et al.
NATURE REVIEWS CANCER (2016)
Targeting Androgen/Estrogen Receptors Crosstalk in Cancer
Michalis V. Karamouzis et al.
TRENDS IN CANCER (2016)
The AF-1-deficient estrogen receptor ERα46 isoform is frequently expressed in human breast tumors
Elodie Chantalat et al.
BREAST CANCER RESEARCH (2016)
Regulation and roles of elongation factor 2 kinase
Christopher G. Proud
BIOCHEMICAL SOCIETY TRANSACTIONS (2015)
Differential Requirements for eIF4E Dose in Normal Development and Cancer
Morgan L. Truitt et al.
CELL (2015)
Divergent androgen regulation of unfolded protein response pathways drives prostate cancer
Xia Sheng et al.
EMBO MOLECULAR MEDICINE (2015)
Integrative analysis of RNA, translation, and protein levels reveals distinct regulatory variation across humans
Can Cenik et al.
GENOME RESEARCH (2015)
Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine
Aurelie Ladang et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2015)
Novel C-4 Heteroaryl 13-cis-Retinamide Mnk/AR Degrading Agents Inhibit Cell Proliferation and Migration and Induce Apoptosis in Human Breast and Prostate Cancer Cells and Suppress Growth of MDA-MB-231 Human Breast and CWR22Rv1 Human Prostate Tumor Xenografts in Mice
Hannah W. Mbatia et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Integrated genomic and transcriptomic analysis of human brain metastases identifies alterations of potential clinical significance
Jodi M. Saunus et al.
JOURNAL OF PATHOLOGY (2015)
Targeting the translation machinery in cancer
Mamatha Bhat et al.
NATURE REVIEWS DRUG DISCOVERY (2015)
Estrogen receptor a inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regression
Neal D. Andruska et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
The malignant phenotype in breast cancer is driven by eIF4A1-mediated changes in the translational landscape
A. Modelska et al.
CELL DEATH & DISEASE (2015)
Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets
Priscilla K. Brastianos et al.
CANCER DISCOVERY (2015)
Simultaneous targeting of androgen receptor (AR) and MAPK-interacting kinases (MNKs) by novel retinamides inhibits growth of human prostate cancer cell lines
Vidya P. Ramamurthy et al.
ONCOTARGET (2015)
Loss of Estrogen-Regulated microRNA Expression Increases HER2 Signaling and Is Prognostic of Poor Outcome in Luminal Breast Cancer
Shannon T. Bailey et al.
CANCER RESEARCH (2015)
Estrogen receptor alpha drives proliferation in PTEN-deficient prostate carcinoma by stimulating survival signaling, MYC expression and altering glucose sensitivity
Itsuhiro Takizawa et al.
ONCOTARGET (2015)
Everolimus plus exemestane for hormone-receptor-positive, human epidermal growth factor receptor-2-negative advanced breast cancer: overall survival results from BOLERO-2
M. Piccart et al.
ANNALS OF ONCOLOGY (2014)
Targeting PI3K/mTOR Overcomes Resistance to HER2-Targeted Therapy Independent of Feedback Activation of AKT
Neil A. O'Brien et al.
CLINICAL CANCER RESEARCH (2014)
Control of Paip1-Eukayrotic Translation Initiation Factor 3 Interaction by Amino Acids through S6 Kinase
Yvan Martineau et al.
MOLECULAR AND CELLULAR BIOLOGY (2014)
Eukaryotic Elongation Factor 2 Kinase Activity Is Controlled by Multiple Inputs from Oncogenic Signaling
Xuemin Wang et al.
MOLECULAR AND CELLULAR BIOLOGY (2014)
microRNA regulation of mammalian target of rapamycin expression and activity controls estrogen receptor function and RADOO1 sensitivity
Elizabeth C. Martin et al.
MOLECULAR CANCER (2014)
Mutation of the palmitoylation site of estrogen receptor α in vivo reveals tissue-specific roles for membrane versus nuclear actions
Marine Adlanmerini et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
The impact of the endoplasmic reticulum protein-folding environment on cancer development
Miao Wang et al.
NATURE REVIEWS CANCER (2014)
Transcriptome-wide characterization of the eIF4A signature highlights plasticity in translation regulation
Claudia A. Rubio et al.
GENOME BIOLOGY (2014)
Estrogen receptor coregulators and pioneer factors: the orchestrators of mammary gland cell fate and development
Bramanandam Manavathi et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2014)
A phase II study evaluating the toxicity and efficacy of single-agent temsirolimus in chemotherapy-naive castration-resistant prostate cancer
K. Kruczek et al.
BRITISH JOURNAL OF CANCER (2013)
Phase 2 Trial of Single-agent Everolimus in Chemotherapy-naive Patients with Castration-resistant Prostate Cancer (SAKK 08/08)
Arnoud J. Templeton et al.
EUROPEAN UROLOGY (2013)
Rapamycin enhances eIF4E phosphorylation by activating MAP kinase-interacting kinase 2a (Mnk2a)
Rebecca L. Stead et al.
FEBS LETTERS (2013)
Randomized Phase III Placebo-Controlled Trial of Letrozole Plus Oral Temsirolimus As First-Line Endocrine Therapy in Postmenopausal Women With Locally Advanced or Metastatic Breast Cancer
Antonio C. Wolff et al.
JOURNAL OF CLINICAL ONCOLOGY (2013)
Crosstalk between mTOR complexes
Jianling Xie et al.
NATURE CELL BIOLOGY (2013)
eIF4F suppression in breast cancer affects maintenance and progression
Z. Nasr et al.
ONCOGENE (2013)
Targeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein
C. Jin et al.
ONCOGENE (2013)
Molecular circuit involving KLK4 integrates androgen and mTOR signaling in prostate cancer
Yang Jin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
Jianjiong Gao et al.
SCIENCE SIGNALING (2013)
Androgen receptor inclusions acquire GRP78/BiP to ameliorate androgen-induced protein misfolding stress in embryonic stem cells
Y-C Yang et al.
CELL DEATH & DISEASE (2013)
Pharmacological brake-release of mRNA translation enhances cognitive memory
Carmela Sidrauski et al.
ELIFE (2013)
Phase II trial of RAD001 and bicalutamide for castration-resistant prostate cancer
Mari Nakabayashi et al.
BJU INTERNATIONAL (2012)
eIF4E/4E-BP Ratio Predicts the Efficacy of mTOR Targeted Therapies
Tommy Alain et al.
CANCER RESEARCH (2012)
Rapamycin toxicity in MIN6 cells and rat and human islets is mediated by the inhibition of mTOR complex 2 (mTORC2)
A. D. Barlow et al.
DIABETOLOGIA (2012)
mTOR inhibitors in breast cancer: A systematic review
Flora Zagouri et al.
GYNECOLOGIC ONCOLOGY (2012)
Translational Homeostasis via the mRNA Cap-Binding Protein, elF4E
Akiko Yanagiya et al.
MOLECULAR CELL (2012)
Comprehensive molecular portraits of human breast tumours
Daniel C. Koboldt et al.
NATURE (2012)
The translational landscape of mTOR signalling steers cancer initiation and metastasis
Andrew C. Hsieh et al.
NATURE (2012)
Translational control in cellular and developmental processes
Jian Kong et al.
NATURE REVIEWS GENETICS (2012)
The unfolded protein response: controlling cell fate decisions under ER stress and beyond
Claudio Hetz
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
Everolimus in Postmenopausal Hormone-Receptor-Positive Advanced Breast Cancer
Jose Baselga et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data
Ethan Cerami et al.
CANCER DISCOVERY (2012)
Aberrations in translational regulation are associated with poor prognosis in hormone receptor-positive breast cancer
Funda Meric-Bernstam et al.
BREAST CANCER RESEARCH (2012)
Formation of the eIF4F Translation-Initiation Complex Determines Sensitivity to Anticancer Drugs Targeting the EGFR and HER2 Receptors
Pierre Zindy et al.
CANCER RESEARCH (2011)
Androgen Receptor and Nutrient Signaling Pathways Coordinate the Demand for Increased Amino Acid Transport during Prostate Cancer Progression
Qian Wang et al.
CANCER RESEARCH (2011)
FKBP51 regulation of AKT/protein kinase B phosphorylation
Liewei Wang
CURRENT OPINION IN PHARMACOLOGY (2011)
The IGF Pathway Regulates ERα through a S6K1-Dependent Mechanism in Breast Cancer Cells
Marc A. Becker et al.
MOLECULAR ENDOCRINOLOGY (2011)
Phosphatidylinositol 3-kinase pathway activation in breast cancer brain metastases
Barbara Adamo et al.
BREAST CANCER RESEARCH (2011)
A Pharmacodynamic Study of Rapamycin in Men with Intermediate- to High-Risk Localized Prostate Cancer
Andrew J. Armstrong et al.
CLINICAL CANCER RESEARCH (2010)
eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression
Luc Furic et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer
Sherene Loi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Breast and prostate cancer: more similar than different
Gail P. Risbridger et al.
NATURE REVIEWS CANCER (2010)
Rapamycin inhibits mTORC1, but not completely
Carson C. Thoreen et al.
AUTOPHAGY (2009)
PIK3CA and PIK3CB Inhibition Produce Synthetic Lethality when Combined with Estrogen Deprivation in Estrogen Receptor-Positive Breast Cancer
Robert J. Crowder et al.
CANCER RESEARCH (2009)
Widespread Estrogen-Dependent Repression of microRNAs Involved in Breast Tumor Cell Growth
Gerard Maillot et al.
CANCER RESEARCH (2009)
DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival
Timothy R. Peterson et al.
CELL (2009)
PIK3CA Mutation Associates with Improved Outcome in Breast Cancer
Kevin Kalinsky et al.
CLINICAL CANCER RESEARCH (2009)
An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1
Carson C. Thoreen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Randomized Phase II Study Comparing Two Schedules of Everolimus in Patients With Recurrent/Metastatic Breast Cancer: NCIC Clinical Trials Group IND.163
Susan L. Ellard et al.
JOURNAL OF CLINICAL ONCOLOGY (2009)
Antitumor Activity and Mechanism of Action of the Cyclopenta[b]benzofuran, Silvestrol
Regina Cencic et al.
PLOS ONE (2009)
The estrogen receptor-α-induced microRNA signature regulates itself and its transcriptional response
Leandro Castellano et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
The oral mTOR inhibitor RAD001 (everolimus) in combination with letrozole in patients with advanced breast cancer: Results of a phase I study with pharmacokinetics
Ahmad Awada et al.
EUROPEAN JOURNAL OF CANCER (2008)
Regulation of androgen receptor transcriptional activity by rapamycin in prostate cancer cell proliferation and survival
Y. Wang et al.
ONCOGENE (2008)
Comprehensive analysis of oncogenic effects of PIK3CA mutations in human mammary epithelial cells
Haijun Zhang et al.
BREAST CANCER RESEARCH AND TREATMENT (2008)
The selectivity of protein kinase inhibitors: a further update
Jenny Bain et al.
BIOCHEMICAL JOURNAL (2007)
Extranuclear steroid receptors: Nature and actions
Stephen R. Hammes et al.
ENDOCRINE REVIEWS (2007)
Estrogen signaling via a linear pathway involving insulin-like growth factor I receptor, matrix metalloproteinases, and epidermal growth factor receptor to activate mitogen-activated protein kinase in MCF-7 breast cancer cells
Robert X. -D. Song et al.
ENDOCRINOLOGY (2007)
Gene expression profiles of prostate cancer reveal involvement of multiple molecular pathways in the metastatic process
Uma R. Chandran et al.
BMC CANCER (2007)
An inherent role of microtubule network in the action of nuclear receptor
Bramanandam Manavathi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Estrogen-induced activation of mammalian target of rapamycin is mediated via tuberin and the small GTPase ras homologue enriched in brain
Jane Yu et al.
CANCER RESEARCH (2006)
Testosterone regulates FGF-2 expression during testis maturation by an IRES-dependent translational mechanism (vol 20, pg 476, 2006)
Irma G. Gonzalez-Herrera et al.
FASEB JOURNAL (2006)
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
DD Sarbassov et al.
MOLECULAR CELL (2006)
Phosphorylation and functional inactivation of TSC2 by Erk: Implications for tuberous sclerosis and cancer pathogenesis
Li Ma et al.
CELL (2006)
Testosterone regulates FGF-2 expression during testis maturation by an IRES-dependent translational mechanism
IG Gonzalez-Herrera et al.
FASEB JOURNAL (2006)
Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells
SJ Isakoff et al.
CANCER RESEARCH (2005)
mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events
MK Holz et al.
CELL (2005)
Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression
S Varambally et al.
CANCER CELL (2005)
Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer
S Chan et al.
JOURNAL OF CLINICAL ONCOLOGY (2005)
Phosphorylation and functional inactivation of TSC2 by Erk: Implications for tuberous sclerosis and cancer pathogenesis
L Ma et al.
CELL (2005)
Nuclear hormone receptor co-repressors
A Baniahmad
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2005)
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
PP Roux et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Identification and validation of novel androgen-regulated genes in prostate cancer
AM Velasco et al.
ENDOCRINOLOGY (2004)
Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development
T Ueda et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor α
L Qing et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Gene expression alterations in prostate cancer predicting tumor aggression and preceding development of malignancy
YP Yu et al.
JOURNAL OF CLINICAL ONCOLOGY (2004)
Gene expression analysis of human prostate carcinoma during hormonal therapy identifies androgen-responsive genes and mechanisms of therapy resistance
J Holzbeierlein et al.
AMERICAN JOURNAL OF PATHOLOGY (2004)
Estrogen receptor corepressors - a role in human breast cancer?
KM Dobrzycka et al.
ENDOCRINE-RELATED CANCER (2003)
Myocardial ischemia and increased heart work modulate the phosphorylation state of eukaryotic elongation factor-2
S Horman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Proximal events in signaling by plasma membrane estrogen receptors
M Razandi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation
HS Yang et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Androgen-induced expression of endoplasmic reticulum (ER) stress response genes in prostate cancer cells
T Segawa et al.
ONCOGENE (2002)
Akt regulates growth by directly phosphorylating Tsc2
CJ Potter et al.
NATURE CELL BIOLOGY (2002)
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
K Inoki et al.
NATURE CELL BIOLOGY (2002)
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-Kinase/Akt pathway
BD Manning et al.
MOLECULAR CELL (2002)
Identification of a conserved motif required for mTOR signaling
SS Schalm et al.
CURRENT BIOLOGY (2002)
Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase
XM Wang et al.
EMBO JOURNAL (2001)