4.6 Article

Repurposing Niclosamide for Targeting Pancreatic Cancer by Inhibiting Hh/Gli Non-Canonical Axis of Gsk3β

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The novel driver gene ASAP2 is a potential druggable target in pancreatic cancer

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Summary: The study identified ASAP2 as a novel driver gene in PDAC, with high expression contributing to a poor prognosis and promoting tumor growth by facilitating cell cycle progression. Niclosamide, repositioned as a drug targeting the ASAP2 pathway, suppresses PDAC growth by inhibiting ASAP2 expression.

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